FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2177293891> ?p ?o ?g. }

• W2177293891 endingPage "491" @default.
• W2177293891 startingPage "481" @default.
• W2177293891 abstract "Integration between comparative biology and cellular/molecular biology has helped advance understanding of the structure, function and physiology of the vertebrate small heat shock proteins αA- and αB-crystallin. These proteins are expressed at high concentration in the eye lens where they contribute to transparency and refractive power. But they also function similarly to molecular chaperones by preventing the aggregation of denatured proteins that can cause opacities, or cataracts. α-crystallins also serve a number of other roles in and out of the lens that are still not completely understood. Comparative examination of α-crystallins and closely related small heat shock proteins from diverse taxa has helped provide insights into the proteins' three-dimensional shape and structure/function relationships. Until recently, no studies had examined the tissue specific expression or chaperone-like activity of α-crystallins from a non-mammalian vertebrate. I have been investigating the α-crystallins of the zebrafish, Danio rerio, as a first step towards utilizing the bony fishes as a model group for understanding the evolution of α-crystallin function. Zebrafish αA-crystallin displays similar structure and expression and increased chaperone-like activity compared to its human orthologue. Zebrafish αB-crystallin, however, has a truncated C-terminal extension, more limited expression and lower chaperone-like activity than its human orthologue. These data suggest that αA-crystallin physiological function may be conserved between zebrafish and mammals, while αB-crystallin physiological function has diverged. Understanding zebrafish α-crystallin physiology is necessary before this species can be used for developmental and genetic studies, and provides a foundation for further comparative studies." @default.
• W2177293891 created "2016-06-24" @default.
• W2177293891 creator A5000476263 @default.
• W2177293891 date "2003-08-01" @default.
• W2177293891 modified "2023-09-27" @default.
• W2177293891 title "A Comparative View of Alpha Crystallins: The contribution of comparative studies to understanding function" @default.
• W2177293891 cites W1472944105 @default.
• W2177293891 cites W1531043145 @default.
• W2177293891 cites W1563177871 @default.
• W2177293891 cites W1581064972 @default.
• W2177293891 cites W1604252033 @default.
• W2177293891 cites W1653551216 @default.
• W2177293891 cites W1790977108 @default.
• W2177293891 cites W1797775581 @default.
• W2177293891 cites W1876533241 @default.
• W2177293891 cites W191130402 @default.
• W2177293891 cites W1980043509 @default.
• W2177293891 cites W1980387809 @default.
• W2177293891 cites W1987657904 @default.
• W2177293891 cites W1991465960 @default.
• W2177293891 cites W1996263880 @default.
• W2177293891 cites W1997675834 @default.
• W2177293891 cites W1998134951 @default.
• W2177293891 cites W2007892210 @default.
• W2177293891 cites W2010958261 @default.
• W2177293891 cites W2012432749 @default.
• W2177293891 cites W2013288236 @default.
• W2177293891 cites W2017083439 @default.
• W2177293891 cites W2018084854 @default.
• W2177293891 cites W2019270143 @default.
• W2177293891 cites W2021258456 @default.
• W2177293891 cites W2021325723 @default.
• W2177293891 cites W2034579187 @default.
• W2177293891 cites W2035919478 @default.
• W2177293891 cites W2044031095 @default.
• W2177293891 cites W2044122905 @default.
• W2177293891 cites W2045430710 @default.
• W2177293891 cites W2058355704 @default.
• W2177293891 cites W2058595471 @default.
• W2177293891 cites W2062660916 @default.
• W2177293891 cites W2065335617 @default.
• W2177293891 cites W2076521338 @default.
• W2177293891 cites W2078383532 @default.
• W2177293891 cites W2078590146 @default.
• W2177293891 cites W2084521013 @default.
• W2177293891 cites W2087401128 @default.
• W2177293891 cites W2093924477 @default.
• W2177293891 cites W2113950913 @default.
• W2177293891 cites W2115644880 @default.
• W2177293891 cites W2116426914 @default.
• W2177293891 cites W2144544590 @default.
• W2177293891 cites W2148619437 @default.
• W2177293891 cites W2149182598 @default.
• W2177293891 cites W2160609891 @default.
• W2177293891 cites W2166500974 @default.
• W2177293891 cites W2166627352 @default.
• W2177293891 cites W2170444891 @default.
• W2177293891 cites W2180663818 @default.
• W2177293891 cites W2410623943 @default.
• W2177293891 cites W2419747921 @default.
• W2177293891 cites W304299129 @default.
• W2177293891 cites W69243547 @default.
• W2177293891 doi "https://doi.org/10.1093/icb/43.4.481" @default.
• W2177293891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21680456" @default.
• W2177293891 hasPublicationYear "2003" @default.
• W2177293891 type Work @default.
• W2177293891 sameAs 2177293891 @default.
• W2177293891 citedByCount "14" @default.
• W2177293891 countsByYear W21772938912012 @default.
• W2177293891 countsByYear W21772938912013 @default.
• W2177293891 countsByYear W21772938912015 @default.
• W2177293891 countsByYear W21772938912018 @default.
• W2177293891 countsByYear W21772938912020 @default.
• W2177293891 countsByYear W21772938912023 @default.
• W2177293891 crossrefType "journal-article" @default.
• W2177293891 hasAuthorship W2177293891A5000476263 @default.
• W2177293891 hasBestOaLocation W21772938911 @default.
• W2177293891 hasConcept C104317684 @default.
• W2177293891 hasConcept C14036430 @default.
• W2177293891 hasConcept C142724271 @default.
• W2177293891 hasConcept C167625842 @default.
• W2177293891 hasConcept C19843653 @default.
• W2177293891 hasConcept C199216141 @default.
• W2177293891 hasConcept C205260736 @default.
• W2177293891 hasConcept C2775962898 @default.
• W2177293891 hasConcept C2776878037 @default.
• W2177293891 hasConcept C2778961482 @default.
• W2177293891 hasConcept C2780384893 @default.
• W2177293891 hasConcept C54355233 @default.
• W2177293891 hasConcept C68991219 @default.
• W2177293891 hasConcept C71924100 @default.
• W2177293891 hasConcept C7263354 @default.
• W2177293891 hasConcept C78458016 @default.
• W2177293891 hasConcept C86803240 @default.
• W2177293891 hasConcept C95444343 @default.
• W2177293891 hasConceptScore W2177293891C104317684 @default.
• W2177293891 hasConceptScore W2177293891C14036430 @default.
• W2177293891 hasConceptScore W2177293891C142724271 @default.

• next