Matches in SemOpenAlex for { <https://semopenalex.org/work/W2177294890> ?p ?o ?g. }
- W2177294890 abstract "Although the original US porcine epidemic diarrhea virus (PEDV) was confirmed as highly virulent by multiple studies, the virulence of spike-insertion deletion (S-INDEL) PEDV strains is undefined. In this study, 3-4 day-old conventional suckling piglets were inoculated with S-INDEL PEDV Iowa106 (4 pig litters) to study its virulence. Two litters of age-matched piglets were inoculated with either the original US PEDV PC21A or mock as positive and negative controls, respectively. Subsequently, all pigs were challenged with the original US PEDV PC21A on 21-29 days post-inoculation (dpi) to assess cross-protection. All S-INDEL Iowa106- and the original US PC21A-inoculated piglets developed diarrhea. However, the severity of clinical signs, mortality (0-75%) and fecal PEDV RNA shedding titers varied among the four S-INDEL Iowa106-inoculated litters. Compared with the original PC21A, piglets euthanized/died acutely from S-INDEL Iowa106 infection had relatively milder villous atrophy, lower antigen scores and more limited intestinal infection. Two of four S-INDEL Iowa106-infected sows and the original PC21A-infected sow showed anorexia and watery diarrhea for 1-4 days. After the original PC21A challenge, a subset (13/16) of S-INDEL Iowa106-inoculated piglets developed diarrhea, whereas all (5/5) and no (0/4) pigs in the mock and original PC21A-inoculated pigs had diarrhea, respectively. Our results suggest that the virulence of S-INDEL PEDV Iowa106 was less than the original US PEDV PC21A in suckling pigs, with 100% morbidity and 18% (6/33) overall (0-75%) mortality in suckling pigs depending on factors such as the sow's health and lactation and the piglets' birth weight. Prior infection by S-INDEL Iowa106 provided partial cross-protection to piglets against the original PC21A challenge at 21-29 dpi." @default.
- W2177294890 created "2016-06-24" @default.
- W2177294890 creator A5009560249 @default.
- W2177294890 creator A5027980950 @default.
- W2177294890 creator A5048299323 @default.
- W2177294890 creator A5051040052 @default.
- W2177294890 creator A5056565688 @default.
- W2177294890 creator A5064559752 @default.
- W2177294890 creator A5065101788 @default.
- W2177294890 creator A5068247833 @default.
- W2177294890 creator A5072050412 @default.
- W2177294890 date "2015-11-20" @default.
- W2177294890 modified "2023-09-26" @default.
- W2177294890 title "Experimental infection of a US spike-insertion deletion porcine epidemic diarrhea virus in conventional nursing piglets and cross-protection to the original US PEDV infection" @default.
- W2177294890 cites W1554543951 @default.
- W2177294890 cites W1823361762 @default.
- W2177294890 cites W1928983587 @default.
- W2177294890 cites W1948873942 @default.
- W2177294890 cites W1966828056 @default.
- W2177294890 cites W1971558192 @default.
- W2177294890 cites W1984503159 @default.
- W2177294890 cites W2001237578 @default.
- W2177294890 cites W2010915723 @default.
- W2177294890 cites W2011424578 @default.
- W2177294890 cites W2012504769 @default.
- W2177294890 cites W2017897989 @default.
- W2177294890 cites W2019615563 @default.
- W2177294890 cites W2036159030 @default.
- W2177294890 cites W2037827426 @default.
- W2177294890 cites W2055938371 @default.
- W2177294890 cites W2056297553 @default.
- W2177294890 cites W2057826589 @default.
- W2177294890 cites W2060799480 @default.
- W2177294890 cites W2084387345 @default.
- W2177294890 cites W2094023848 @default.
- W2177294890 cites W2097957152 @default.
- W2177294890 cites W2102974062 @default.
- W2177294890 cites W2127187679 @default.
- W2177294890 cites W2141260814 @default.
- W2177294890 cites W2146064229 @default.
- W2177294890 cites W2154632404 @default.
- W2177294890 cites W2166475442 @default.
- W2177294890 cites W2166880388 @default.
- W2177294890 cites W2172178713 @default.
- W2177294890 cites W2292371441 @default.
- W2177294890 cites W2333595520 @default.
- W2177294890 doi "https://doi.org/10.1186/s13567-015-0278-9" @default.
- W2177294890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4654902" @default.
- W2177294890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26589292" @default.
- W2177294890 hasPublicationYear "2015" @default.
- W2177294890 type Work @default.
- W2177294890 sameAs 2177294890 @default.
- W2177294890 citedByCount "71" @default.
- W2177294890 countsByYear W21772948902016 @default.
- W2177294890 countsByYear W21772948902017 @default.
- W2177294890 countsByYear W21772948902018 @default.
- W2177294890 countsByYear W21772948902019 @default.
- W2177294890 countsByYear W21772948902020 @default.
- W2177294890 countsByYear W21772948902021 @default.
- W2177294890 countsByYear W21772948902022 @default.
- W2177294890 countsByYear W21772948902023 @default.
- W2177294890 crossrefType "journal-article" @default.
- W2177294890 hasAuthorship W2177294890A5009560249 @default.
- W2177294890 hasAuthorship W2177294890A5027980950 @default.
- W2177294890 hasAuthorship W2177294890A5048299323 @default.
- W2177294890 hasAuthorship W2177294890A5051040052 @default.
- W2177294890 hasAuthorship W2177294890A5056565688 @default.
- W2177294890 hasAuthorship W2177294890A5064559752 @default.
- W2177294890 hasAuthorship W2177294890A5065101788 @default.
- W2177294890 hasAuthorship W2177294890A5068247833 @default.
- W2177294890 hasAuthorship W2177294890A5072050412 @default.
- W2177294890 hasBestOaLocation W21772948901 @default.
- W2177294890 hasConcept C104317684 @default.
- W2177294890 hasConcept C126322002 @default.
- W2177294890 hasConcept C12914427 @default.
- W2177294890 hasConcept C159047783 @default.
- W2177294890 hasConcept C180032290 @default.
- W2177294890 hasConcept C203014093 @default.
- W2177294890 hasConcept C2522874641 @default.
- W2177294890 hasConcept C2775862345 @default.
- W2177294890 hasConcept C2779802037 @default.
- W2177294890 hasConcept C55493867 @default.
- W2177294890 hasConcept C60987743 @default.
- W2177294890 hasConcept C61716771 @default.
- W2177294890 hasConcept C71924100 @default.
- W2177294890 hasConcept C86803240 @default.
- W2177294890 hasConcept C89423630 @default.
- W2177294890 hasConceptScore W2177294890C104317684 @default.
- W2177294890 hasConceptScore W2177294890C126322002 @default.
- W2177294890 hasConceptScore W2177294890C12914427 @default.
- W2177294890 hasConceptScore W2177294890C159047783 @default.
- W2177294890 hasConceptScore W2177294890C180032290 @default.
- W2177294890 hasConceptScore W2177294890C203014093 @default.
- W2177294890 hasConceptScore W2177294890C2522874641 @default.
- W2177294890 hasConceptScore W2177294890C2775862345 @default.
- W2177294890 hasConceptScore W2177294890C2779802037 @default.
- W2177294890 hasConceptScore W2177294890C55493867 @default.
- W2177294890 hasConceptScore W2177294890C60987743 @default.
- W2177294890 hasConceptScore W2177294890C61716771 @default.
- W2177294890 hasConceptScore W2177294890C71924100 @default.