Matches in SemOpenAlex for { <https://semopenalex.org/work/W2177402703> ?p ?o ?g. }
- W2177402703 endingPage "798" @default.
- W2177402703 startingPage "787" @default.
- W2177402703 abstract "At present, direct data on risk from protracted or fractionated radiation exposure at low dose rates have been limited largely to studies of populations exposed to low cumulative doses with resulting low statistical power. We evaluated the cancer risks associated with protracted exposure to external whole-body gamma radiation at high cumulative doses (the average dose is 0.8 Gy and the highest doses exceed 10 Gy) in Russian nuclear workers. Cancer deaths in a cohort of about 21,500 nuclear workers who began working at the Mayak complex between 1948 and 1972 were ascertained from death certificates and autopsy reports with follow-up through December 1997. Excess relative risk models were used to estimate solid cancer and leukemia risks associated with external gamma-radiation dose with adjustment for effects of plutonium exposures. Both solid cancer and leukemia death rates increased significantly with increasing gamma-ray dose (P < 0.001). Under a linear dose-response model, the excess relative risk for lung, liver and skeletal cancers as a group (668 deaths) adjusted for plutonium exposure is 0.30 per gray (P < 0.001) and 0.08 per gray (P < 0.001) for all other solid cancers (1062 deaths). The solid cancer dose-response functions appear to be nonlinear, with the excess risk estimates at doses of less than 3 Gy being about twice those predicted by the linear model. Plutonium exposure was associated with increased risks both for lung, liver and skeletal cancers (the sites of primary plutonium deposition) and for other solid cancers as a group. A significant dose response, with no indication of plutonium exposure effects, was found for leukemia. Excess risks for leukemia exhibited a significant dependence on the time since the dose was received. For doses received within 3 to 5 years of death the excess relative risk per gray was estimated to be about 7 (P < 0.001), but this risk was only 0.45 (P = 0.02) for doses received 5 to 45 years prior to death. External gamma-ray exposures significantly increased risks of both solid cancers and leukemia in this large cohort of men and women with occupational radiation exposures. Risks at doses of less than 1 Gy may be slightly lower than those seen for doses arising from acute exposures in the atomic bomb survivors. As dose estimates for the Mayak workers are improved, it should be possible to obtain more precise estimates of solid cancer and leukemia risks from protracted external radiation exposure in this cohort." @default.
- W2177402703 created "2016-06-24" @default.
- W2177402703 creator A5001139707 @default.
- W2177402703 creator A5002299331 @default.
- W2177402703 creator A5007596794 @default.
- W2177402703 creator A5011333128 @default.
- W2177402703 creator A5021401003 @default.
- W2177402703 creator A5025744906 @default.
- W2177402703 creator A5037521465 @default.
- W2177402703 creator A5055127282 @default.
- W2177402703 creator A5081183653 @default.
- W2177402703 creator A5083739532 @default.
- W2177402703 creator A5084896750 @default.
- W2177402703 date "2003-06-01" @default.
- W2177402703 modified "2023-09-30" @default.
- W2177402703 title "Cancer Mortality Risk among Workers at the Mayak Nuclear Complex" @default.
- W2177402703 cites W1973009157 @default.
- W2177402703 cites W1975829266 @default.
- W2177402703 cites W1978299850 @default.
- W2177402703 cites W1988688019 @default.
- W2177402703 cites W1989040702 @default.
- W2177402703 cites W1992018435 @default.
- W2177402703 cites W1996691873 @default.
- W2177402703 cites W2002209762 @default.
- W2177402703 cites W2017577599 @default.
- W2177402703 cites W2025304963 @default.
- W2177402703 cites W2025666947 @default.
- W2177402703 cites W2030810311 @default.
- W2177402703 cites W2038837113 @default.
- W2177402703 cites W2051878533 @default.
- W2177402703 cites W2070704336 @default.
- W2177402703 cites W2076833989 @default.
- W2177402703 cites W2080243578 @default.
- W2177402703 cites W2098990836 @default.
- W2177402703 cites W2172899499 @default.
- W2177402703 cites W2175352287 @default.
- W2177402703 cites W2176058732 @default.
- W2177402703 cites W2319782924 @default.
- W2177402703 cites W2334624221 @default.
- W2177402703 cites W2409449455 @default.
- W2177402703 cites W2462527102 @default.
- W2177402703 cites W4244251055 @default.
- W2177402703 doi "https://doi.org/10.1667/0033-7587(2003)159[0787:cmrawa]2.0.co;2" @default.
- W2177402703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12751962" @default.
- W2177402703 hasPublicationYear "2003" @default.
- W2177402703 type Work @default.
- W2177402703 sameAs 2177402703 @default.
- W2177402703 citedByCount "138" @default.
- W2177402703 countsByYear W21774027032012 @default.
- W2177402703 countsByYear W21774027032013 @default.
- W2177402703 countsByYear W21774027032014 @default.
- W2177402703 countsByYear W21774027032015 @default.
- W2177402703 countsByYear W21774027032016 @default.
- W2177402703 countsByYear W21774027032017 @default.
- W2177402703 countsByYear W21774027032018 @default.
- W2177402703 countsByYear W21774027032019 @default.
- W2177402703 countsByYear W21774027032020 @default.
- W2177402703 countsByYear W21774027032021 @default.
- W2177402703 countsByYear W21774027032022 @default.
- W2177402703 countsByYear W21774027032023 @default.
- W2177402703 crossrefType "journal-article" @default.
- W2177402703 hasAuthorship W2177402703A5001139707 @default.
- W2177402703 hasAuthorship W2177402703A5002299331 @default.
- W2177402703 hasAuthorship W2177402703A5007596794 @default.
- W2177402703 hasAuthorship W2177402703A5011333128 @default.
- W2177402703 hasAuthorship W2177402703A5021401003 @default.
- W2177402703 hasAuthorship W2177402703A5025744906 @default.
- W2177402703 hasAuthorship W2177402703A5037521465 @default.
- W2177402703 hasAuthorship W2177402703A5055127282 @default.
- W2177402703 hasAuthorship W2177402703A5081183653 @default.
- W2177402703 hasAuthorship W2177402703A5083739532 @default.
- W2177402703 hasAuthorship W2177402703A5084896750 @default.
- W2177402703 hasConcept C121608353 @default.
- W2177402703 hasConcept C126322002 @default.
- W2177402703 hasConcept C143998085 @default.
- W2177402703 hasConcept C151032500 @default.
- W2177402703 hasConcept C177322064 @default.
- W2177402703 hasConcept C185592680 @default.
- W2177402703 hasConcept C2776256026 @default.
- W2177402703 hasConcept C2778461978 @default.
- W2177402703 hasConcept C2989005 @default.
- W2177402703 hasConcept C44249647 @default.
- W2177402703 hasConcept C540271850 @default.
- W2177402703 hasConcept C71924100 @default.
- W2177402703 hasConcept C82789193 @default.
- W2177402703 hasConceptScore W2177402703C121608353 @default.
- W2177402703 hasConceptScore W2177402703C126322002 @default.
- W2177402703 hasConceptScore W2177402703C143998085 @default.
- W2177402703 hasConceptScore W2177402703C151032500 @default.
- W2177402703 hasConceptScore W2177402703C177322064 @default.
- W2177402703 hasConceptScore W2177402703C185592680 @default.
- W2177402703 hasConceptScore W2177402703C2776256026 @default.
- W2177402703 hasConceptScore W2177402703C2778461978 @default.
- W2177402703 hasConceptScore W2177402703C2989005 @default.
- W2177402703 hasConceptScore W2177402703C44249647 @default.
- W2177402703 hasConceptScore W2177402703C540271850 @default.
- W2177402703 hasConceptScore W2177402703C71924100 @default.
- W2177402703 hasConceptScore W2177402703C82789193 @default.