FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2177403062> ?p ?o ?g. }

• W2177403062 abstract "Over-treatment of estrogen receptor positive (ER+), lymph node-negative (LNN) breast cancer patients with chemotherapy is a pressing clinical problem that can be addressed by improving techniques to predict tumor metastatic potential. Here we demonstrate that analysis of second harmonic generation (SHG) emission direction in primary tumor biopsies can provide prognostic information about the metastatic outcome of ER+, LNN breast cancer, as well as stage 1 colorectal adenocarcinoma.SHG is an optical signal produced by fibrillar collagen. The ratio of the forward-to-backward emitted SHG signals (F/B) is sensitive to changes in structure of individual collagen fibers. F/B from excised primary tumor tissue was measured in a retrospective study of LNN breast cancer patients who had received no adjuvant systemic therapy and related to metastasis-free survival (MFS) and overall survival (OS) rates. In addition, F/B was studied for its association with the length of progression-free survival (PFS) in a subgroup of ER+ patients who received tamoxifen as first-line treatment for recurrent disease, and for its relation with OS in stage I colorectal and stage 1 lung adenocarcinoma patients.In 125 ER+, but not in 96 ER-negative (ER-), LNN breast cancer patients an increased F/B was significantly associated with a favorable MFS and OS (log rank trend for MFS: p = 0.004 and for OS: p = 0.03). On the other hand, an increased F/B was associated with shorter PFS in 60 ER+ recurrent breast cancer patients treated with tamoxifen (log rank trend p = 0.02). In stage I colorectal adenocarcinoma, an increased F/B was significantly related to poor OS (log rank trend p = 0.03), however this relationship was not statistically significant in stage I lung adenocarcinoma.Within ER+, LNN breast cancer specimens the F/B can stratify patients based upon their potential for tumor aggressiveness. This offers a matrix-focused method to predict metastatic outcome that is complementary to genomic cell-focused methods. In combination, this and other methods may contribute to improved metastatic prediction, and hence may help to reduce patient over-treatment." @default.
• W2177403062 created "2016-06-24" @default.
• W2177403062 creator A5040594661 @default.
• W2177403062 creator A5043655122 @default.
• W2177403062 creator A5047492118 @default.
• W2177403062 creator A5049800878 @default.
• W2177403062 creator A5051087982 @default.
• W2177403062 creator A5057943415 @default.
• W2177403062 creator A5065531168 @default.
• W2177403062 creator A5066680524 @default.
• W2177403062 creator A5071991781 @default.
• W2177403062 date "2015-11-24" @default.
• W2177403062 modified "2023-10-13" @default.
• W2177403062 title "Using second harmonic generation to predict patient outcome in solid tumors" @default.
• W2177403062 cites W1816051628 @default.
• W2177403062 cites W1985727076 @default.
• W2177403062 cites W1987719890 @default.
• W2177403062 cites W2000771269 @default.
• W2177403062 cites W2004280628 @default.
• W2177403062 cites W2011380505 @default.
• W2177403062 cites W2025190273 @default.
• W2177403062 cites W2053159655 @default.
• W2177403062 cites W2054661538 @default.
• W2177403062 cites W2056254464 @default.
• W2177403062 cites W2060783173 @default.
• W2177403062 cites W2062265555 @default.
• W2177403062 cites W2065835875 @default.
• W2177403062 cites W2076937190 @default.
• W2177403062 cites W2091995773 @default.
• W2177403062 cites W2099540110 @default.
• W2177403062 cites W2100203276 @default.
• W2177403062 cites W2101728107 @default.
• W2177403062 cites W2105882193 @default.
• W2177403062 cites W2119565091 @default.
• W2177403062 cites W2128970119 @default.
• W2177403062 cites W2128985829 @default.
• W2177403062 cites W2130588419 @default.
• W2177403062 cites W2132619562 @default.
• W2177403062 cites W2143033696 @default.
• W2177403062 cites W2156144879 @default.
• W2177403062 cites W2163563958 @default.
• W2177403062 cites W2165776880 @default.
• W2177403062 cites W2169064382 @default.
• W2177403062 cites W4245024447 @default.
• W2177403062 cites W4293107555 @default.
• W2177403062 doi "https://doi.org/10.1186/s12885-015-1911-8" @default.
• W2177403062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4659155" @default.
• W2177403062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26603532" @default.
• W2177403062 hasPublicationYear "2015" @default.
• W2177403062 type Work @default.
• W2177403062 sameAs 2177403062 @default.
• W2177403062 citedByCount "29" @default.
• W2177403062 countsByYear W21774030622017 @default.
• W2177403062 countsByYear W21774030622018 @default.
• W2177403062 countsByYear W21774030622019 @default.
• W2177403062 countsByYear W21774030622020 @default.
• W2177403062 countsByYear W21774030622021 @default.
• W2177403062 countsByYear W21774030622022 @default.
• W2177403062 countsByYear W21774030622023 @default.
• W2177403062 crossrefType "journal-article" @default.
• W2177403062 hasAuthorship W2177403062A5040594661 @default.
• W2177403062 hasAuthorship W2177403062A5043655122 @default.
• W2177403062 hasAuthorship W2177403062A5047492118 @default.
• W2177403062 hasAuthorship W2177403062A5049800878 @default.
• W2177403062 hasAuthorship W2177403062A5051087982 @default.
• W2177403062 hasAuthorship W2177403062A5057943415 @default.
• W2177403062 hasAuthorship W2177403062A5065531168 @default.
• W2177403062 hasAuthorship W2177403062A5066680524 @default.
• W2177403062 hasAuthorship W2177403062A5071991781 @default.
• W2177403062 hasBestOaLocation W21774030621 @default.
• W2177403062 hasConcept C121608353 @default.
• W2177403062 hasConcept C126322002 @default.
• W2177403062 hasConcept C143998085 @default.
• W2177403062 hasConcept C146357865 @default.
• W2177403062 hasConcept C151730666 @default.
• W2177403062 hasConcept C2777176818 @default.
• W2177403062 hasConcept C2779013556 @default.
• W2177403062 hasConcept C2780140570 @default.
• W2177403062 hasConcept C2780283643 @default.
• W2177403062 hasConcept C526805850 @default.
• W2177403062 hasConcept C530470458 @default.
• W2177403062 hasConcept C71924100 @default.
• W2177403062 hasConcept C84606932 @default.
• W2177403062 hasConcept C86803240 @default.
• W2177403062 hasConceptScore W2177403062C121608353 @default.
• W2177403062 hasConceptScore W2177403062C126322002 @default.
• W2177403062 hasConceptScore W2177403062C143998085 @default.
• W2177403062 hasConceptScore W2177403062C146357865 @default.
• W2177403062 hasConceptScore W2177403062C151730666 @default.
• W2177403062 hasConceptScore W2177403062C2777176818 @default.
• W2177403062 hasConceptScore W2177403062C2779013556 @default.
• W2177403062 hasConceptScore W2177403062C2780140570 @default.
• W2177403062 hasConceptScore W2177403062C2780283643 @default.
• W2177403062 hasConceptScore W2177403062C526805850 @default.
• W2177403062 hasConceptScore W2177403062C530470458 @default.
• W2177403062 hasConceptScore W2177403062C71924100 @default.
• W2177403062 hasConceptScore W2177403062C84606932 @default.
• W2177403062 hasConceptScore W2177403062C86803240 @default.
• W2177403062 hasIssue "1" @default.
• W2177403062 hasLocation W21774030621 @default.

• next