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- W2177452037 abstract "Objective To investigate the effect of cetuximab on inhibition of proliferation and apoptosis of A549 cells with K-ras mutation. Methods The inhibition of proliferation and apoptosis rate of A549 cells induced by cetuximab were analyzed by CCK-8 assay and flow cytometry, respectively. The disparity on gene expression of A549 cells was compared between cetuximab group and control group by microarray. Results Treatment with cetuximab resulted in inhibition of proliferation and apoptosis of A549 cells with K-ras mutation. There were 10 genes upregulated and 9 genes downregulated after cetuximab treatment. Realtime PCR confirmed that the gene expressions of STAT1 and IGFBP3 of A549 cells were upregulated obviously after cetuximab treatment. Conclusions Cetuximab may have an inducing effect on inhibition of proliferation and apoptosis on non-small cell lung cancer cell line A549 which has undergone K-ras mutation. STAT1 and IGFBP3 up-regulation may be one of the mechanisms underlying inhibitory effect of ceturimab on NSCLC." @default.
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- W2177452037 date "2013-01-09" @default.
- W2177452037 modified "2023-09-24" @default.
- W2177452037 title "Effect of cetuximab on proliferation and gene expression of A549 cells and its underlying mechanism" @default.
- W2177452037 hasPublicationYear "2013" @default.
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