Matches in SemOpenAlex for { <https://semopenalex.org/work/W2177524772> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2177524772 endingPage "F515" @default.
- W2177524772 startingPage "F509" @default.
- W2177524772 abstract "This study investigated the recovery of renal proximal tubule cellular (RPTC) functions following oxidant-induced sublethal injury. tert-Butylhydroperoxide (TBHP) treatment resulted in 24% cell death and loss 4 h following the exposure. The remaining sublethally injured RPTC proliferated, and monolayer DNA content returned to control values on day 4 following TBHP exposure. Basal oxygen consumption (Qo2) and ATP content in sublethally injured RPTC were decreased 64 and 63%, respectively, at 4 h and returned to control values on day 6. Net lactate consumption decreased 71% at 4 h and returned to control values on day 4. In contrast, net glutamine consumption increased 2.7-fold at 4 h and returned to control values on day 6. Ouabain-sensitive Qo2, Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) activity, and Na(+)-coupled glucose transport were inhibited 77, 88, and 83%, respectively, at 4 h and recovered to control values on day 6. These data show that 1) mitochondrial function, Na(+)-K(+)-ATPase activity, active Na+ transport, and Na(+)-coupled glucose transport are decreased in sublethally injured RPTC following oxidant exposure and are repaired over time; 2) monolayer regeneration precedes the recovery of mitochondrial and transport functions, and 3) sublethal injury and subsequent regeneration are associated with alterations in metabolic substrate utilization. These results suggest that oxidant-induced sublethal injury to RPTC may contribute to renal dysfunction and that RPTC can repair and regain cellular functions following oxidant injury." @default.
- W2177524772 created "2016-06-24" @default.
- W2177524772 creator A5001811896 @default.
- W2177524772 creator A5004628839 @default.
- W2177524772 creator A5038826154 @default.
- W2177524772 creator A5045567965 @default.
- W2177524772 date "1998-03-01" @default.
- W2177524772 modified "2023-09-24" @default.
- W2177524772 title "Recovery of cellular functions following oxidant injury" @default.
- W2177524772 cites W1775749144 @default.
- W2177524772 cites W1968220296 @default.
- W2177524772 cites W1975842923 @default.
- W2177524772 cites W1977779461 @default.
- W2177524772 cites W1982465260 @default.
- W2177524772 cites W1985465059 @default.
- W2177524772 cites W1985657656 @default.
- W2177524772 cites W2000097190 @default.
- W2177524772 cites W2005094104 @default.
- W2177524772 cites W2010779418 @default.
- W2177524772 cites W2033773934 @default.
- W2177524772 cites W2045281126 @default.
- W2177524772 cites W2052816377 @default.
- W2177524772 cites W2065264404 @default.
- W2177524772 cites W2065633930 @default.
- W2177524772 cites W2067729477 @default.
- W2177524772 cites W2118564489 @default.
- W2177524772 cites W2150912898 @default.
- W2177524772 cites W2157920972 @default.
- W2177524772 cites W2180569405 @default.
- W2177524772 cites W2208951677 @default.
- W2177524772 cites W2222785860 @default.
- W2177524772 cites W2318560859 @default.
- W2177524772 cites W2921436947 @default.
- W2177524772 doi "https://doi.org/10.1152/ajprenal.1998.274.3.f509" @default.
- W2177524772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9530267" @default.
- W2177524772 hasPublicationYear "1998" @default.
- W2177524772 type Work @default.
- W2177524772 sameAs 2177524772 @default.
- W2177524772 citedByCount "21" @default.
- W2177524772 countsByYear W21775247722013 @default.
- W2177524772 countsByYear W21775247722014 @default.
- W2177524772 countsByYear W21775247722016 @default.
- W2177524772 countsByYear W21775247722018 @default.
- W2177524772 crossrefType "journal-article" @default.
- W2177524772 hasAuthorship W2177524772A5001811896 @default.
- W2177524772 hasAuthorship W2177524772A5004628839 @default.
- W2177524772 hasAuthorship W2177524772A5038826154 @default.
- W2177524772 hasAuthorship W2177524772A5045567965 @default.
- W2177524772 hasBestOaLocation W21775247721 @default.
- W2177524772 hasConcept C178790620 @default.
- W2177524772 hasConcept C181199279 @default.
- W2177524772 hasConcept C185592680 @default.
- W2177524772 hasConcept C23265538 @default.
- W2177524772 hasConcept C2779133857 @default.
- W2177524772 hasConcept C2779349466 @default.
- W2177524772 hasConcept C28859421 @default.
- W2177524772 hasConcept C515207424 @default.
- W2177524772 hasConcept C537181965 @default.
- W2177524772 hasConcept C55493867 @default.
- W2177524772 hasConcept C86803240 @default.
- W2177524772 hasConcept C95444343 @default.
- W2177524772 hasConcept C98274493 @default.
- W2177524772 hasConceptScore W2177524772C178790620 @default.
- W2177524772 hasConceptScore W2177524772C181199279 @default.
- W2177524772 hasConceptScore W2177524772C185592680 @default.
- W2177524772 hasConceptScore W2177524772C23265538 @default.
- W2177524772 hasConceptScore W2177524772C2779133857 @default.
- W2177524772 hasConceptScore W2177524772C2779349466 @default.
- W2177524772 hasConceptScore W2177524772C28859421 @default.
- W2177524772 hasConceptScore W2177524772C515207424 @default.
- W2177524772 hasConceptScore W2177524772C537181965 @default.
- W2177524772 hasConceptScore W2177524772C55493867 @default.
- W2177524772 hasConceptScore W2177524772C86803240 @default.
- W2177524772 hasConceptScore W2177524772C95444343 @default.
- W2177524772 hasConceptScore W2177524772C98274493 @default.
- W2177524772 hasIssue "3" @default.
- W2177524772 hasLocation W21775247721 @default.
- W2177524772 hasLocation W21775247722 @default.
- W2177524772 hasOpenAccess W2177524772 @default.
- W2177524772 hasPrimaryLocation W21775247721 @default.
- W2177524772 hasRelatedWork W1155355392 @default.
- W2177524772 hasRelatedWork W1432800987 @default.
- W2177524772 hasRelatedWork W1535442687 @default.
- W2177524772 hasRelatedWork W1607983725 @default.
- W2177524772 hasRelatedWork W1995291788 @default.
- W2177524772 hasRelatedWork W2019172800 @default.
- W2177524772 hasRelatedWork W2028005950 @default.
- W2177524772 hasRelatedWork W2040980247 @default.
- W2177524772 hasRelatedWork W2075079345 @default.
- W2177524772 hasRelatedWork W2312681270 @default.
- W2177524772 hasVolume "274" @default.
- W2177524772 isParatext "false" @default.
- W2177524772 isRetracted "false" @default.
- W2177524772 magId "2177524772" @default.
- W2177524772 workType "article" @default.