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• W2177546315 endingPage "119" @default.
• W2177546315 startingPage "108" @default.
• W2177546315 abstract "IgM is an important class of serum antibody that mediates the clearance of apoptotic and altered cells through complement-dependent and -independent mechanisms. IgM mediates protection against infection and may play an important role in controlling Plasmodium falciparum malaria. IgM provides new routes to more effective drugs and vaccines. Fcμ-binding proteins expressed on the surfaces of both infected erythrocytes and merozoites facilitate immune evasion through diverse mechanisms. Immunoglobulin M (IgM) is an ancient antibody class that is found in all vertebrates, with the exception of coelacanths, and is indispensable in both innate and adaptive immunity. The equally ancient human malaria parasite, Plasmodium falciparum, formed an intimate relationship with IgM with which it co-evolved. In this article, we discuss the association between IgM and human malaria parasites, building on several recent publications that implicate IgM as a crucial molecule that determines both host and parasite survival. Consequently, a better understanding of this association may lead to the development of improved intervention strategies. Immunoglobulin M (IgM) is an ancient antibody class that is found in all vertebrates, with the exception of coelacanths, and is indispensable in both innate and adaptive immunity. The equally ancient human malaria parasite, Plasmodium falciparum, formed an intimate relationship with IgM with which it co-evolved. In this article, we discuss the association between IgM and human malaria parasites, building on several recent publications that implicate IgM as a crucial molecule that determines both host and parasite survival. Consequently, a better understanding of this association may lead to the development of improved intervention strategies. the biochemical process of programmed cell death (PCD) that occurs in multicellular organisms, leading to characteristic cell changes and death. Apoptotic cells are cleared by IgM and complement activation. a process whereby cells degrade intracellular components to promote their own survival in response to cellular stress. biochemical pathways that have evolved to label pathogens and/or apoptotic cells for elimination. The classical pathway links to adaptive immune systems through IgM. The alternative and lectin pathways provide antibody-independent ‘innate’ immunity, and the alternative pathway is linked to and amplifies the classical pathway. leucocytes that sense tissue injury, capture antigens, and present those antigens to T lymphocytes to induce immunity to foreign antigens and enforce tolerance to self-antigens. the portion of an antibody responsible for binding to immunoglobulin receptors on cells and the C1q component of complement. a membrane-anchored or soluble glycoprotein that binds to the Fc constant region of antibodies. the part of an antibody molecule which contains the antigen-combining site, consisting of a light chain and part of the heavy chain; it is produced by enzymatic digestion. a carbohydrate found in many organisms. It is not found in primates and humans whose immune systems recognize it as foreign and produce xenoreactive IgM antibodies to it. These can lead to organ rejection after transplantation. the first antibody produced in a primary immune response and that is largely confined to the intravascular pool. It is frequently associated with the immune response to antigenically complex, blood-borne infectious organisms. IgM is the most efficient activator of complement. a therapeutic preparation containing polyvalent IgG and/or IgM pooled from human donors. IVIg is used to treat primary immune deficiencies and is increasingly being used in the treatment of autoimmune disease. carbohydrate-binding proteins that are highly specific for sugar moieties. a process by which phagocytosis is facilitated by the deposition of opsonins (e.g., antibody and complement) on the antigen. a process by which cells consume extracellular particles to form an internal vesicle containing those particles. the ability of an antibody molecule to bind to more than one epitope or antigen." @default.
• W2177546315 created "2016-06-24" @default.
• W2177546315 creator A5008707676 @default.
• W2177546315 creator A5009937760 @default.
• W2177546315 creator A5017039123 @default.
• W2177546315 creator A5086030940 @default.
• W2177546315 date "2016-02-01" @default.
• W2177546315 modified "2023-10-03" @default.
• W2177546315 title "Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria" @default.
• W2177546315 cites W1506451184 @default.
• W2177546315 cites W1514481003 @default.
• W2177546315 cites W1532438728 @default.
• W2177546315 cites W1554784279 @default.
• W2177546315 cites W1573250191 @default.
• W2177546315 cites W1586942665 @default.
• W2177546315 cites W1604107517 @default.
• W2177546315 cites W1651341107 @default.
• W2177546315 cites W1826006191 @default.
• W2177546315 cites W1828479613 @default.
• W2177546315 cites W1851059221 @default.
• W2177546315 cites W1936038771 @default.
• W2177546315 cites W1939325746 @default.
• W2177546315 cites W1954099879 @default.
• W2177546315 cites W1959426503 @default.
• W2177546315 cites W1965623009 @default.
• W2177546315 cites W1966275153 @default.
• W2177546315 cites W1967563793 @default.
• W2177546315 cites W1968677737 @default.
• W2177546315 cites W1976270460 @default.
• W2177546315 cites W1977112775 @default.
• W2177546315 cites W1979249470 @default.
• W2177546315 cites W1979541272 @default.
• W2177546315 cites W1980219722 @default.
• W2177546315 cites W1982879896 @default.
• W2177546315 cites W1983536542 @default.
• W2177546315 cites W1983538138 @default.
• W2177546315 cites W1987053568 @default.
• W2177546315 cites W1988536357 @default.
• W2177546315 cites W1998253454 @default.
• W2177546315 cites W1998953208 @default.
• W2177546315 cites W1999647461 @default.
• W2177546315 cites W2002049130 @default.
• W2177546315 cites W2002884478 @default.
• W2177546315 cites W2008281271 @default.
• W2177546315 cites W2009948019 @default.
• W2177546315 cites W2012593576 @default.
• W2177546315 cites W2017185765 @default.
• W2177546315 cites W2017604221 @default.
• W2177546315 cites W2017953300 @default.
• W2177546315 cites W2022264956 @default.
• W2177546315 cites W2024774586 @default.
• W2177546315 cites W2025086964 @default.
• W2177546315 cites W2026483075 @default.
• W2177546315 cites W2028350716 @default.
• W2177546315 cites W2033742471 @default.
• W2177546315 cites W2035660467 @default.
• W2177546315 cites W2035711162 @default.
• W2177546315 cites W2040242408 @default.
• W2177546315 cites W2040835861 @default.
• W2177546315 cites W2041759310 @default.
• W2177546315 cites W2043418529 @default.
• W2177546315 cites W2044098624 @default.
• W2177546315 cites W2046267069 @default.
• W2177546315 cites W2048769067 @default.
• W2177546315 cites W2049551663 @default.
• W2177546315 cites W2049653343 @default.
• W2177546315 cites W2051151466 @default.
• W2177546315 cites W2052975401 @default.
• W2177546315 cites W2053119113 @default.
• W2177546315 cites W2055724947 @default.
• W2177546315 cites W2056433345 @default.
• W2177546315 cites W2062032776 @default.
• W2177546315 cites W2068894321 @default.
• W2177546315 cites W2070692447 @default.
• W2177546315 cites W2072975902 @default.
• W2177546315 cites W2074919825 @default.
• W2177546315 cites W2076000327 @default.
• W2177546315 cites W2076274573 @default.
• W2177546315 cites W2080504796 @default.
• W2177546315 cites W2081944454 @default.
• W2177546315 cites W2085319285 @default.
• W2177546315 cites W2087517413 @default.
• W2177546315 cites W2087840267 @default.
• W2177546315 cites W2090214639 @default.
• W2177546315 cites W2090624104 @default.
• W2177546315 cites W2101154896 @default.
• W2177546315 cites W2103122522 @default.
• W2177546315 cites W2103516617 @default.
• W2177546315 cites W2103845816 @default.
• W2177546315 cites W2107646820 @default.
• W2177546315 cites W2112676752 @default.
• W2177546315 cites W2112944944 @default.
• W2177546315 cites W2113900462 @default.
• W2177546315 cites W2114198497 @default.
• W2177546315 cites W2115000683 @default.
• W2177546315 cites W2115974508 @default.
• W2177546315 cites W2120400371 @default.
• W2177546315 cites W2120606777 @default.

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