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• W2177564725 startingPage "39" @default.
• W2177564725 abstract "Atherosclerosis is a slowly progressing systemic (multifocal) arterial disease with focal manifestations caused by one or relatively few stenotic and/or thrombosis-prone (vulnerable) plaques. The coronary arteries, carotid arteries, ilio-femoral arteries, and aorta are especially susceptible to atherosclerosis. The most devastating consequences of atherosclerosis, such as heart attack and stroke, are usually caused by thrombosis precipitated by plaque rupture. Although the morphology of ruptured plaques has been known for decades, it remains poorly understood why a single plaque among many plaques becomes vulnerable and suddenly ruptures. Plaque rupture requires the presence of a lipid-rich (necrotic) core covered by a thin fibrous cap, and the development and detection of “core and cap” are currently explored in basic and clinical research. Other plaque and plaque-related features may be useful markers of vulnerability, including plaque inflammation (macrophage density and activity), neovascularization (angiogenesis), hemorrhage, microcalcification, adventitial inflammation (lymphocytes), and expansive remodeling. Vascular imaging and function testing have the potential to provide a comprehensive assessment of atherosclerosis, including detection of plaque burden, plaque vulnerability, and disease activity. The search for better markers of cardiovascular risk must continue. With the traditional risk-factor-based approach in primary prevention, most individuals destined for a near-term heart attack or stroke are misclassified and not identified as being at high risk. Consequently, they are not offered appropriate preventive therapy. Detection of subclinical but high-risk atherosclerosis may change this unfortunate situation." @default.
• W2177564725 created "2016-06-24" @default.
• W2177564725 creator A5002521329 @default.
• W2177564725 creator A5037729662 @default.
• W2177564725 creator A5080654235 @default.
• W2177564725 creator A5089496191 @default.
• W2177564725 date "2010-02-08" @default.
• W2177564725 modified "2023-09-25" @default.
• W2177564725 title "Pathology of Vulnerability Caused by High-Risk (Vulnerable) Arteries and Plaques" @default.
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• W2177564725 doi "https://doi.org/10.1007/978-1-60327-179-0_3" @default.
• W2177564725 hasPublicationYear "2010" @default.
• W2177564725 type Work @default.

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