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• W2177590354 abstract "Hyperpolarization causing smooth muscle relaxation contributes to the maintenance of vascular homeostasis, particularly in small-calibre arteries and arterioles. It may also become a compensatory vasodilator mechanism upregulated in states with impaired nitric oxide (NO) availability. Bioassay of vascular hyperpolarization in the human circulation has been hampered by the complexity of mechanisms involved and the limited availability of investigational tools. Firm evidence, however, supports the notion that hyperpolarization participates in the regulation of resting vasodilator tone and vascular reactivity in healthy subjects. In addition, an enhanced endothelium-derived hyperpolarization contributes to both resting and agonist-stimulated vasodilation in a variety of cardiovascular risk conditions and disease. Thus, hyperpolarization mediated by epoxyeicosatrienoic acids (EETs) and H2O2 has been observed in coronary arterioles of patients with coronary artery disease. Similarly, ouabain-sensitive and EETs-mediated hyperpolarization has been observed to compensate for NO deficiency in patients with essential hypertension. Moreover, in non-hypertensive patients with multiple cardiovascular risk factors and in hypercholesterolaemia, KCa channel-mediated vasodilation appears to be activated. A novel paradigm establishes that perivascular adipose tissue (PVAT) is an additional regulator of vascular tone/function and endothelium is not the only agent in vascular hyperpolarization. Indeed, some PVAT-derived relaxing substances, such as adiponectin and angiotensin 1-7, may exert anticontractile and vasodilator actions by the opening of KCa channels in smooth muscle cells. Conversely, PVAT-derived factors impair coronary vasodilation via differential inhibition of some K+ channels. In view of adipose tissue abnormalities occurring in human obesity, changes in PVAT-dependent hyperpolarization may be relevant for vascular dysfunction also in this condition." @default.
• W2177590354 created "2016-06-24" @default.
• W2177590354 creator A5022926640 @default.
• W2177590354 creator A5037604705 @default.
• W2177590354 creator A5085843137 @default.
• W2177590354 date "2015-12-12" @default.
• W2177590354 modified "2023-10-03" @default.
• W2177590354 title "Vascular hyperpolarization in human physiology and cardiovascular risk conditions and disease" @default.
• W2177590354 cites W1561322846 @default.
• W2177590354 cites W1964860017 @default.
• W2177590354 cites W1965430847 @default.
• W2177590354 cites W1965697927 @default.
• W2177590354 cites W1975329996 @default.
• W2177590354 cites W1982135265 @default.
• W2177590354 cites W1982580263 @default.
• W2177590354 cites W1982994793 @default.
• W2177590354 cites W1983404645 @default.
• W2177590354 cites W1983798804 @default.
• W2177590354 cites W1990482492 @default.
• W2177590354 cites W1993452291 @default.
• W2177590354 cites W1993760969 @default.
• W2177590354 cites W1998856849 @default.
• W2177590354 cites W2004270313 @default.
• W2177590354 cites W2006405826 @default.
• W2177590354 cites W2008140913 @default.
• W2177590354 cites W2011584026 @default.
• W2177590354 cites W2013517541 @default.
• W2177590354 cites W2015319932 @default.
• W2177590354 cites W2017499594 @default.
• W2177590354 cites W2018345997 @default.
• W2177590354 cites W2023313831 @default.
• W2177590354 cites W2026072548 @default.
• W2177590354 cites W2027480261 @default.
• W2177590354 cites W2028087945 @default.
• W2177590354 cites W2028516053 @default.
• W2177590354 cites W2029632724 @default.
• W2177590354 cites W2033611003 @default.
• W2177590354 cites W2034320492 @default.
• W2177590354 cites W2035328056 @default.
• W2177590354 cites W2036715732 @default.
• W2177590354 cites W2041001842 @default.
• W2177590354 cites W2044038692 @default.
• W2177590354 cites W2045888765 @default.
• W2177590354 cites W2057033953 @default.
• W2177590354 cites W2058994971 @default.
• W2177590354 cites W2059513440 @default.
• W2177590354 cites W2063503589 @default.
• W2177590354 cites W2064489455 @default.
• W2177590354 cites W2066590292 @default.
• W2177590354 cites W2067696654 @default.
• W2177590354 cites W2071499846 @default.
• W2177590354 cites W2074481216 @default.
• W2177590354 cites W2078653194 @default.
• W2177590354 cites W2082392252 @default.
• W2177590354 cites W2083959622 @default.
• W2177590354 cites W2089332717 @default.
• W2177590354 cites W2099087033 @default.
• W2177590354 cites W2099257249 @default.
• W2177590354 cites W2099642241 @default.
• W2177590354 cites W2102447197 @default.
• W2177590354 cites W2104974272 @default.
• W2177590354 cites W2107300948 @default.
• W2177590354 cites W2107826105 @default.
• W2177590354 cites W2108583183 @default.
• W2177590354 cites W2110909360 @default.
• W2177590354 cites W2111037290 @default.
• W2177590354 cites W2115244899 @default.
• W2177590354 cites W2116479949 @default.
• W2177590354 cites W2116704287 @default.
• W2177590354 cites W2116763228 @default.
• W2177590354 cites W2125532194 @default.
• W2177590354 cites W2126624423 @default.
• W2177590354 cites W2132388025 @default.
• W2177590354 cites W2135609788 @default.
• W2177590354 cites W2136242238 @default.
• W2177590354 cites W2136592038 @default.
• W2177590354 cites W2138173257 @default.
• W2177590354 cites W2139580508 @default.
• W2177590354 cites W2140254836 @default.
• W2177590354 cites W2142900879 @default.
• W2177590354 cites W2144273980 @default.
• W2177590354 cites W2146021361 @default.
• W2177590354 cites W2146361547 @default.
• W2177590354 cites W2148334824 @default.
• W2177590354 cites W2148887017 @default.
• W2177590354 cites W2150276386 @default.
• W2177590354 cites W2152809661 @default.
• W2177590354 cites W2152862968 @default.
• W2177590354 cites W2153819503 @default.
• W2177590354 cites W2154380411 @default.
• W2177590354 cites W2161842755 @default.
• W2177590354 cites W2164371271 @default.
• W2177590354 cites W2164878884 @default.
• W2177590354 cites W2166140382 @default.
• W2177590354 cites W2168598639 @default.
• W2177590354 cites W2171129716 @default.
• W2177590354 cites W2171474373 @default.
• W2177590354 cites W2197389618 @default.

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