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• W2177759025 abstract "Excessive activation of Toll-like receptor 4 (TLR4)/MD-2 by lipopolysaccharide (LPS) causes septic shock. We previously produced an inhibitory antibody, HT52, against LPS-induced human TLR4 activation independently of LPS binding of MD-2. Consistent with the hypothesis that HT52 recognizes the epitopes inherent to inhibitory antibodies, we generated an HT52-crossblockable antibody and revealed the relationship between its inhibitory activity and the anti-TLR4 antibody epitope. Leucine-rich repeat 2 was identified as an inhibitory epitope, and Phe(75), Ser(76) and Pro(79) as antigenic determinants. These findings provide a way to design therapeutic antibodies targeted to TLR4 that are distinct from LPS analog antagonists targeting MD-2." @default.
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• W2177759025 date "2015-11-19" @default.
• W2177759025 modified "2023-10-15" @default.
• W2177759025 title "Leucine‐rich repeat 2 of human Toll‐like receptor 4 contains the binding site for inhibitory monoclonal antibodies" @default.
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• W2177759025 doi "https://doi.org/10.1016/j.febslet.2015.11.018" @default.
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