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• W2177777333 abstract "A variety of P4 motifs have been examined to increase the binding affinity and in vitro anticoagulant potency of our biphenyl 1-(2-naphthyl)-1H-pyrazole-5-carboxylamide-based fXa inhibitors. Highly potent 2-naphthyl-P1 fXa inhibitors (Ki≤2 nM) with improved in vitro anticoagulant activity (2×TG≤1 μM) and respectable pharmacokinetic properties have been discovered." @default.
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• W2177777333 date "2004-03-01" @default.
• W2177777333 modified "2023-09-26" @default.
• W2177777333 title "1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs" @default.
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• W2177777333 doi "https://doi.org/10.1016/j.bmcl.2003.12.053" @default.
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