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- W2177883923 abstract "Different sites in the cell may be involved in the control of myocardial function, but it seems unlikely that any one of these is the sole controlling factor under physiologic and pathologic conditions. Ever since it was realized that cardiac glycosides (CG) directly affect the myocardium (Gold and Cattel, 1940), all major areas of cellular and subcellular activity in the myocardium have been subjected to investigation (Lee and Klaus, 1971). The conclusions drawn from the large body of data, however, remain contradictory in part. In the past, it was thought that the inhibition of the membrane Na+, K +-pump was correlated with the positive isotropic action of CG. Recent developments, however, would seem to require modification of such a simple mechanism, as a growing number of reports point to dissociation of these two effects and to changes in the intracellular environment as the cause of inotropic effects (Murthy et al., 1974; Beeler, 1977; Weingart et al., 1978; Diacono, 1979; La Bella et al., 1979). In fact, small but therapeutically effective doses of CG are even reported to activate the Na+, K +-pump system (Bloom et al., 1974; Peters et al., 1974; Cohen et al., 1976). Other results indicate that the toxic effects of CG may instead be due to alterations in the intracellular ionic composition produced by the inhibition of the Na+, K +-pump (Okita, 1977; Lüllmann and Peters, 1979). Thus, today, we see some of the attention paid in the past to sites located on the outer side of the cellular membrane being diverted to intracellular sites.KeywordsATPase ActivityActin FilamentCardiac MuscleCardiac GlycosideContractile ProteinThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
- W2177883923 created "2016-06-24" @default.
- W2177883923 creator A5020380292 @default.
- W2177883923 creator A5091247792 @default.
- W2177883923 date "1981-01-01" @default.
- W2177883923 modified "2023-09-27" @default.
- W2177883923 title "Effects of Cardiac Glycosides on Myofibrils" @default.
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- W2177883923 doi "https://doi.org/10.1007/978-3-642-68163-9_19" @default.