FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2178008393> ?p ?o ?g. }

• W2178008393 abstract "Epigenetic processes, such as DNA methylation, and molecular chaperones, including FK506-binding protein 51 (FKBP51), are independently implicated in stress-related mental disorders and antidepressant drug action. FKBP51 associates with cyclin-dependent kinase 5 (CDK5), which is one of several kinases that phosphorylates and activates DNA methyltransferase 1 (DNMT1). We searched for a functional link between FKBP51 (encoded by FKBP5) and DNMT1 in cells from mice and humans, including those from depressed patients, and found that FKBP51 competed with its close homolog FKBP52 for association with CDK5. In human embryonic kidney (HEK) 293 cells, expression of FKBP51 displaced FKBP52 from CDK5, decreased the interaction of CDK5 with DNMT1, reduced the phosphorylation and enzymatic activity of DNMT1, and diminished global DNA methylation. In mouse embryonic fibroblasts and primary mouse astrocytes, FKBP51 mediated several effects of paroxetine, namely, decreased the protein-protein interactions of DNMT1 with CDK5 and FKBP52, reduced phosphorylation of DNMT1, and decreased the methylation and increased the expression of the gene encoding brain-derived neurotrophic factor (Bdnf). In human peripheral blood cells, FKBP5 expression inversely correlated with both global and BDNF methylation. Peripheral blood cells isolated from depressed patients that were then treated ex vivo with paroxetine revealed that the abundance of BDNF positively correlated and phosphorylated DNMT1 inversely correlated with that of FKBP51 in cells and with clinical treatment success in patients, supporting the relevance of this FKBP51-directed pathway that prevents epigenetic suppression of gene expression." @default.
• W2178008393 created "2016-06-24" @default.
• W2178008393 creator A5000996668 @default.
• W2178008393 creator A5003863265 @default.
• W2178008393 creator A5017312170 @default.
• W2178008393 creator A5021312103 @default.
• W2178008393 creator A5022380433 @default.
• W2178008393 creator A5025638745 @default.
• W2178008393 creator A5026032684 @default.
• W2178008393 creator A5027113273 @default.
• W2178008393 creator A5030860744 @default.
• W2178008393 creator A5031165242 @default.
• W2178008393 creator A5040738041 @default.
• W2178008393 creator A5046164327 @default.
• W2178008393 creator A5047723483 @default.
• W2178008393 creator A5055586212 @default.
• W2178008393 creator A5058281761 @default.
• W2178008393 creator A5062189732 @default.
• W2178008393 creator A5068459181 @default.
• W2178008393 creator A5072275864 @default.
• W2178008393 creator A5085294417 @default.
• W2178008393 creator A5088866740 @default.
• W2178008393 date "2015-11-24" @default.
• W2178008393 modified "2023-10-07" @default.
• W2178008393 title "Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine" @default.
• W2178008393 cites W1497465798 @default.
• W2178008393 cites W1534737270 @default.
• W2178008393 cites W1554180547 @default.
• W2178008393 cites W1964318956 @default.
• W2178008393 cites W1964670163 @default.
• W2178008393 cites W1966455447 @default.
• W2178008393 cites W1974406383 @default.
• W2178008393 cites W1974793156 @default.
• W2178008393 cites W1975528145 @default.
• W2178008393 cites W1986726446 @default.
• W2178008393 cites W1986875278 @default.
• W2178008393 cites W1988825409 @default.
• W2178008393 cites W1990567745 @default.
• W2178008393 cites W1991246477 @default.
• W2178008393 cites W1992927495 @default.
• W2178008393 cites W1996667997 @default.
• W2178008393 cites W2000855271 @default.
• W2178008393 cites W2002637584 @default.
• W2178008393 cites W2004063027 @default.
• W2178008393 cites W2009579074 @default.
• W2178008393 cites W2012916279 @default.
• W2178008393 cites W2013472031 @default.
• W2178008393 cites W2014874816 @default.
• W2178008393 cites W2017892333 @default.
• W2178008393 cites W2018262243 @default.
• W2178008393 cites W2029243355 @default.
• W2178008393 cites W2035899017 @default.
• W2178008393 cites W2036194871 @default.
• W2178008393 cites W2037815828 @default.
• W2178008393 cites W2038407368 @default.
• W2178008393 cites W2042787057 @default.
• W2178008393 cites W2043313558 @default.
• W2178008393 cites W2046919791 @default.
• W2178008393 cites W2053213384 @default.
• W2178008393 cites W2053569167 @default.
• W2178008393 cites W2056040742 @default.
• W2178008393 cites W2058314819 @default.
• W2178008393 cites W2058519323 @default.
• W2178008393 cites W2058861807 @default.
• W2178008393 cites W2065861453 @default.
• W2178008393 cites W2067004457 @default.
• W2178008393 cites W2072157236 @default.
• W2178008393 cites W2072920261 @default.
• W2178008393 cites W2074871646 @default.
• W2178008393 cites W2075431153 @default.
• W2178008393 cites W2075642168 @default.
• W2178008393 cites W2078021348 @default.
• W2178008393 cites W2078195742 @default.
• W2178008393 cites W2079965790 @default.
• W2178008393 cites W2081273690 @default.
• W2178008393 cites W2084399551 @default.
• W2178008393 cites W2084436053 @default.
• W2178008393 cites W2085926540 @default.
• W2178008393 cites W2089689396 @default.
• W2178008393 cites W2092670527 @default.
• W2178008393 cites W2092765329 @default.
• W2178008393 cites W2093575561 @default.
• W2178008393 cites W2094984646 @default.
• W2178008393 cites W2101870168 @default.
• W2178008393 cites W2107665951 @default.
• W2178008393 cites W2116629441 @default.
• W2178008393 cites W2121016639 @default.
• W2178008393 cites W2122327012 @default.
• W2178008393 cites W2122598723 @default.
• W2178008393 cites W2123064897 @default.
• W2178008393 cites W2124049725 @default.
• W2178008393 cites W2124317383 @default.
• W2178008393 cites W2125138227 @default.
• W2178008393 cites W2128870654 @default.
• W2178008393 cites W2129915465 @default.
• W2178008393 cites W2130374405 @default.
• W2178008393 cites W2130685024 @default.
• W2178008393 cites W2133177768 @default.
• W2178008393 cites W2149557692 @default.
• W2178008393 cites W2152541513 @default.

• next