Matches in SemOpenAlex for { <https://semopenalex.org/work/W2178098051> ?p ?o ?g. }
- W2178098051 endingPage "e1005666" @default.
- W2178098051 startingPage "e1005666" @default.
- W2178098051 abstract "DNA methylation is a key epigenetic regulator in all domains of life, yet the effects of most bacterial DNA methyltransferases on cellular processes are largely undefined. Here, we used diverse techniques, including bisulfite sequencing, transcriptomics, and transposon insertion site sequencing to extensively characterize a 5-methylcytosine (5mC) methyltransferase, VchM, in the cholera pathogen, Vibrio cholerae. We have comprehensively defined VchM’s DNA targets, its genetic interactions and the gene networks that it regulates. Although VchM is a relatively new component of the V. cholerae genome, it is required for optimal V. cholerae growth in vitro and during infection. Unexpectedly, the usually essential σE cell envelope stress pathway is dispensable in ∆vchM V. cholerae, likely due to its lower activation in this mutant and the capacity for VchM methylation to limit expression of some cell envelope modifying genes. Our work illuminates how an acquired DNA methyltransferase can become integrated within complex cell circuits to control critical housekeeping processes." @default.
- W2178098051 created "2016-06-24" @default.
- W2178098051 creator A5011065381 @default.
- W2178098051 creator A5017683749 @default.
- W2178098051 creator A5038868843 @default.
- W2178098051 creator A5056761543 @default.
- W2178098051 creator A5067108842 @default.
- W2178098051 creator A5071245512 @default.
- W2178098051 creator A5071946434 @default.
- W2178098051 date "2015-11-20" @default.
- W2178098051 modified "2023-09-23" @default.
- W2178098051 title "A Cytosine Methytransferase Modulates the Cell Envelope Stress Response in the Cholera Pathogen" @default.
- W2178098051 cites W1534298151 @default.
- W2178098051 cites W1592264528 @default.
- W2178098051 cites W1787690277 @default.
- W2178098051 cites W1891765765 @default.
- W2178098051 cites W1931700765 @default.
- W2178098051 cites W1964249183 @default.
- W2178098051 cites W1971439989 @default.
- W2178098051 cites W1975398616 @default.
- W2178098051 cites W1980812447 @default.
- W2178098051 cites W1985270197 @default.
- W2178098051 cites W1985860073 @default.
- W2178098051 cites W1988480619 @default.
- W2178098051 cites W1989699984 @default.
- W2178098051 cites W1992841053 @default.
- W2178098051 cites W1996267597 @default.
- W2178098051 cites W1997866877 @default.
- W2178098051 cites W2000802512 @default.
- W2178098051 cites W2006495385 @default.
- W2178098051 cites W2006824446 @default.
- W2178098051 cites W2009811059 @default.
- W2178098051 cites W2010855847 @default.
- W2178098051 cites W2012017268 @default.
- W2178098051 cites W2013882590 @default.
- W2178098051 cites W2019226819 @default.
- W2178098051 cites W2021625708 @default.
- W2178098051 cites W2030001008 @default.
- W2178098051 cites W2041025550 @default.
- W2178098051 cites W2046212479 @default.
- W2178098051 cites W2046464222 @default.
- W2178098051 cites W2049174722 @default.
- W2178098051 cites W2052561020 @default.
- W2178098051 cites W2054243030 @default.
- W2178098051 cites W2057671789 @default.
- W2178098051 cites W2058376506 @default.
- W2178098051 cites W2063310269 @default.
- W2178098051 cites W2068199614 @default.
- W2178098051 cites W2075279389 @default.
- W2178098051 cites W2076796342 @default.
- W2178098051 cites W2079444524 @default.
- W2178098051 cites W2100131579 @default.
- W2178098051 cites W2103009708 @default.
- W2178098051 cites W2103112981 @default.
- W2178098051 cites W2107109782 @default.
- W2178098051 cites W2111155960 @default.
- W2178098051 cites W2111272687 @default.
- W2178098051 cites W2114104545 @default.
- W2178098051 cites W2114452222 @default.
- W2178098051 cites W2117212584 @default.
- W2178098051 cites W2118391196 @default.
- W2178098051 cites W2118875492 @default.
- W2178098051 cites W2119148587 @default.
- W2178098051 cites W2125013009 @default.
- W2178098051 cites W2128078820 @default.
- W2178098051 cites W2129075737 @default.
- W2178098051 cites W2131374955 @default.
- W2178098051 cites W2133620956 @default.
- W2178098051 cites W2136139129 @default.
- W2178098051 cites W2142688808 @default.
- W2178098051 cites W2145962307 @default.
- W2178098051 cites W2149689268 @default.
- W2178098051 cites W2150750072 @default.
- W2178098051 cites W2151872368 @default.
- W2178098051 cites W2151969594 @default.
- W2178098051 cites W2155736667 @default.
- W2178098051 cites W2167987107 @default.
- W2178098051 cites W2171194842 @default.
- W2178098051 cites W2171434257 @default.
- W2178098051 cites W2266909067 @default.
- W2178098051 doi "https://doi.org/10.1371/journal.pgen.1005666" @default.
- W2178098051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4654547" @default.
- W2178098051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26588462" @default.
- W2178098051 hasPublicationYear "2015" @default.
- W2178098051 type Work @default.
- W2178098051 sameAs 2178098051 @default.
- W2178098051 citedByCount "31" @default.
- W2178098051 countsByYear W21780980512015 @default.
- W2178098051 countsByYear W21780980512016 @default.
- W2178098051 countsByYear W21780980512017 @default.
- W2178098051 countsByYear W21780980512018 @default.
- W2178098051 countsByYear W21780980512019 @default.
- W2178098051 countsByYear W21780980512020 @default.
- W2178098051 countsByYear W21780980512021 @default.
- W2178098051 countsByYear W21780980512022 @default.
- W2178098051 countsByYear W21780980512023 @default.
- W2178098051 crossrefType "journal-article" @default.
- W2178098051 hasAuthorship W2178098051A5011065381 @default.