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- W2178098853 abstract "The pathogenesis of tuberculosis, caused by Mycobacterium tuberculosis, is largely because of the pathogen's successful entry and survival within macrophages. We predicted that rv3369, a gene encoding a conserved protein, might play a role in the interactions with host cells. To test this, rv3369 gene was heterologously expressed in a nonpathogenic fast-growing Mycobacterium smegmatis strain. The recombinant strain survives better than the control within macrophages, accompanied by more host cell death and a marked higher secretion of interleukin-1β (IL-1β). Furthermore, pharmacological inhibition experiments showed that the NF-κB and ERK pathways were involved in the Rv3369-triggered IL-1β changes. These results provided evidence for the engagement of Rv3369 in the interaction between mycobacteria and host." @default.
- W2178098853 created "2016-06-24" @default.
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- W2178098853 date "2016-02-01" @default.
- W2178098853 modified "2023-09-26" @default.
- W2178098853 title "Rv3369 Induces Cytokine Interleukin-1β Production and Enhances<i>Mycobacterium smegmatis</i>Intracellular Survival" @default.
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- W2178098853 doi "https://doi.org/10.1089/jir.2015.0090" @default.
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