FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2178102917> ?p ?o ?g. }

• W2178102917 endingPage "D113" @default.
• W2178102917 startingPage "D113" @default.
• W2178102917 abstract "Elongation of Very Long chain fatty acids-like 4 (ELOVL4) is a fatty acid elongase responsible for the biosynthesis of very long chain (VLC; ≥ C26) fatty acids in the retina, brain, skin, Meibomian gland, and testes. Heterozygous inheritance of mutant ELOVL4 causes juvenile macular degeneration in autosomal dominant Stargardt-like macular dystrophy (STGD3). Retinal photoreceptors are enriched with VLC polyunsaturated fatty acids (VLC-PUFAs), which have been shown by our group and others to be necessary for the survival of rod photoreceptors. Our group performed a series of studies using mice conditionally depleted of retinal Elovl4 (KO) aimed at understanding the role of VLC-PUFAs in long-term retinal health and function, focusing on the role of these fatty acids in mediating synaptic function between the photoreceptors and the rest of the neural retina. The absence of VLC-PUFA from the retina of KO mice resulted in a marked decrease in retinal b-wave responses of the electroretinogram as well as a decrease in the amplitude of the oscillatory potentials mediated by the neural retina. Although there were no measureable differences between KO and wild type (WT) mice in either pre-synaptic rod calcium channel function or post-synaptic bipolar cell glutamate receptor responses, ultrastructural analysis revealed a marked decrease in the diameter of synaptic vesicles in rod terminals. Recent quantification suggests that this decrease in synaptic vesicle size due to the absence of VLC-PUFAs in KO mice, and the consequent decrease in glutamate content, could account for the decrease in b-wave response amplitudes that were previously measured in these animals." @default.
• W2178102917 created "2016-06-24" @default.
• W2178102917 creator A5004338167 @default.
• W2178102917 creator A5038872556 @default.
• W2178102917 creator A5043873239 @default.
• W2178102917 creator A5059891728 @default.
• W2178102917 creator A5076839165 @default.
• W2178102917 creator A5077784304 @default.
• W2178102917 date "2015-11-27" @default.
• W2178102917 modified "2023-09-26" @default.
• W2178102917 title "Very long-chain fatty acids support synaptic structure and function in the mammalian retina" @default.
• W2178102917 cites W1485407919 @default.
• W2178102917 cites W1567065116 @default.
• W2178102917 cites W1967138719 @default.
• W2178102917 cites W1969570272 @default.
• W2178102917 cites W1971578757 @default.
• W2178102917 cites W1984137433 @default.
• W2178102917 cites W1991804865 @default.
• W2178102917 cites W2019644150 @default.
• W2178102917 cites W2035659802 @default.
• W2178102917 cites W2040477003 @default.
• W2178102917 cites W2042648920 @default.
• W2178102917 cites W2043084962 @default.
• W2178102917 cites W2059163200 @default.
• W2178102917 cites W2059512241 @default.
• W2178102917 cites W2073324143 @default.
• W2178102917 cites W2134846445 @default.
• W2178102917 cites W2137994863 @default.
• W2178102917 cites W2140139153 @default.
• W2178102917 cites W2165685138 @default.
• W2178102917 cites W2167721785 @default.
• W2178102917 cites W2336565533 @default.
• W2178102917 doi "https://doi.org/10.1051/ocl/2015056" @default.
• W2178102917 hasPublicationYear "2015" @default.
• W2178102917 type Work @default.
• W2178102917 sameAs 2178102917 @default.
• W2178102917 citedByCount "7" @default.
• W2178102917 countsByYear W21781029172017 @default.
• W2178102917 countsByYear W21781029172019 @default.
• W2178102917 countsByYear W21781029172021 @default.
• W2178102917 countsByYear W21781029172023 @default.
• W2178102917 crossrefType "journal-article" @default.
• W2178102917 hasAuthorship W2178102917A5004338167 @default.
• W2178102917 hasAuthorship W2178102917A5038872556 @default.
• W2178102917 hasAuthorship W2178102917A5043873239 @default.
• W2178102917 hasAuthorship W2178102917A5059891728 @default.
• W2178102917 hasAuthorship W2178102917A5076839165 @default.
• W2178102917 hasAuthorship W2178102917A5077784304 @default.
• W2178102917 hasBestOaLocation W21781029171 @default.
• W2178102917 hasConcept C126322002 @default.
• W2178102917 hasConcept C130316041 @default.
• W2178102917 hasConcept C134018914 @default.
• W2178102917 hasConcept C148785051 @default.
• W2178102917 hasConcept C169760540 @default.
• W2178102917 hasConcept C170493617 @default.
• W2178102917 hasConcept C19038510 @default.
• W2178102917 hasConcept C2777093970 @default.
• W2178102917 hasConcept C2779113765 @default.
• W2178102917 hasConcept C2780827179 @default.
• W2178102917 hasConcept C41625074 @default.
• W2178102917 hasConcept C543025807 @default.
• W2178102917 hasConcept C55493867 @default.
• W2178102917 hasConcept C61174792 @default.
• W2178102917 hasConcept C71924100 @default.
• W2178102917 hasConcept C86803240 @default.
• W2178102917 hasConcept C95444343 @default.
• W2178102917 hasConceptScore W2178102917C126322002 @default.
• W2178102917 hasConceptScore W2178102917C130316041 @default.
• W2178102917 hasConceptScore W2178102917C134018914 @default.
• W2178102917 hasConceptScore W2178102917C148785051 @default.
• W2178102917 hasConceptScore W2178102917C169760540 @default.
• W2178102917 hasConceptScore W2178102917C170493617 @default.
• W2178102917 hasConceptScore W2178102917C19038510 @default.
• W2178102917 hasConceptScore W2178102917C2777093970 @default.
• W2178102917 hasConceptScore W2178102917C2779113765 @default.
• W2178102917 hasConceptScore W2178102917C2780827179 @default.
• W2178102917 hasConceptScore W2178102917C41625074 @default.
• W2178102917 hasConceptScore W2178102917C543025807 @default.
• W2178102917 hasConceptScore W2178102917C55493867 @default.
• W2178102917 hasConceptScore W2178102917C61174792 @default.
• W2178102917 hasConceptScore W2178102917C71924100 @default.
• W2178102917 hasConceptScore W2178102917C86803240 @default.
• W2178102917 hasConceptScore W2178102917C95444343 @default.
• W2178102917 hasIssue "1" @default.
• W2178102917 hasLocation W21781029171 @default.
• W2178102917 hasLocation W21781029172 @default.
• W2178102917 hasLocation W21781029173 @default.
• W2178102917 hasOpenAccess W2178102917 @default.
• W2178102917 hasPrimaryLocation W21781029171 @default.
• W2178102917 hasRelatedWork W1991960614 @default.
• W2178102917 hasRelatedWork W2019374231 @default.
• W2178102917 hasRelatedWork W2035394716 @default.
• W2178102917 hasRelatedWork W2060643724 @default.
• W2178102917 hasRelatedWork W2102326852 @default.
• W2178102917 hasRelatedWork W2154264779 @default.
• W2178102917 hasRelatedWork W2402345182 @default.
• W2178102917 hasRelatedWork W2552889832 @default.
• W2178102917 hasRelatedWork W4232762672 @default.

• next