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• W2178176650 abstract "The use of platelet-rich plasma (PRP) has become more generally accepted, and implant dentists are using PRP more frequently to promote the healing of oral surgical and/or periodontal wounds. Critical elements of PRP are thought to be growth factors contained within the concentrated platelets. These growth factors are known to promote soft-tissue healing, angiogenesis and osteogenesis. We present a rapid, simple, and inexpensive methodology for preparing PRP using the Cliniseal centrifuge method. This study demonstrates that platelets are concentrated approximately 6-fold without altering platelet morphology. Further we demonstrate that key growth factors, platelet-derived growth factor BB (PDGF-BB), transforming growth factor B (TGF-B1), vasculature endothelial growth factor (VEGF), and epidermal growth factor (EGF) are present in comparable or higher concentrations than those reported with the use of other techniques. Prolonged bench set time (>3 hours) after centrifugation resulted in decreased concentration of TGF-B1 but not decreased concentration of PDGF-BB, VEGF, or EGF. This study confirms the molecular aspects of PRP obtained using this inexpensive and efficient methodology." @default.
• W2178176650 created "2016-06-24" @default.
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• W2178176650 date "2008-02-01" @default.
• W2178176650 modified "2023-09-26" @default.
• W2178176650 title "An Analysis of a Rapid, Simple, and Inexpensive Technique Used to Obtain Platelet-Rich Plasma for Use in Clinical Practice" @default.
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• W2178176650 doi "https://doi.org/10.1563/1548-1336(2008)34[25:aaoars]2.0.co;2" @default.
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