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• W2178186469 abstract "Cardiac c-kit + progenitor cells are important for maintaining cardiac homeostasis and can potentially contribute to myocardial repair. However, cellular physiology of human cardiac c-kit + progenitor cells is not well understood. The present study investigates the functional store-operated Ca 2+ entry (SOCE) channels and the potential role in regulating cell cycling and migration using confocal microscopy, RT-PCR, Western blot, coimmunoprecipitation, cell proliferation, and migration assays. We found that SOCE channels mediated Ca 2+ influx, and TRPC1, STIM1, and Orai1 were involved in the formation of SOCE channels in human cardiac c-kit + progenitor cells. Silencing TRPC1, STIM1, or Orai1 with the corresponding siRNA significantly reduced the Ca 2+ signaling through SOCE channels, decreased cell proliferation and migration, and reduced expression of cyclin D1, cyclin E, and/or p-Akt. Our results demonstrate the novel information that Ca 2+ signaling through SOCE channels regulates cell cycling and migration via activating cyclin D1, cyclin E, and/or p-Akt in human cardiac c-kit + cells." @default.
• W2178186469 created "2016-06-24" @default.
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• W2178186469 date "2015-11-15" @default.
• W2178186469 modified "2023-10-17" @default.
• W2178186469 title "Roles of store-operated Ca²⁺channels in regulating cell cycling and migration of human cardiac c-kit⁺progenitor cells" @default.
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• W2178186469 doi "https://doi.org/10.1152/ajpheart.00260.2015" @default.
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