FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2178270601> ?p ?o ?g. }

• W2178270601 endingPage "3014" @default.
• W2178270601 startingPage "3008" @default.
• W2178270601 abstract "Background: Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease characterized by destruction of the interlobular bile ducts and a striking female predominance. The aim of this study was to identify associations between estrogen receptor (ESR) gene polymorphisms with the risk of developing PBC and abnormal serum liver tests in a Chinese population. Methods: Thirty-six patients with PBC (case group) and 35 healthy individuals (control group) from the First Hospital of Jilin University were studied. Whole genomic DNA was extracted from all the participants. Three single-nucleotide polymorphisms (rs2234693, rs2228480, and rs3798577) from ESR1 and two (rs1256030 and rs1048315) from ESR2 were analyzed by a pyrosequencing method. Demographic data and liver biochemical data were collected. Results: Subjects with the T allele at ESR2 rs1256030 had 1.5 times higher risk of developing PBC than those with the C allele (odds ratio [OR] = 2.1277, 95% confidence interval [CI] = 1.1872–4.5517). Haplotypes TGC of ESR1 rs2234693, rs2228480, and rs3798577 were risk factors for having PBC. The C allele at ESR1 rs2234693 was associated with abnormal alkaline phosphatase (OR = 5.2469, 95% CI = 1.3704–20.0895) and gamma-glutamyl transferase (OR = 3.4286, 95% CI = 1.0083–13.6578) levels in PBC patients. Conclusions: ESR2 rs1256030 T allele may be a significant risk factor for the development of PBC. Screening for patients with gene polymorphisms may help to make early diagnoses in patients with PBC." @default.
• W2178270601 created "2016-06-24" @default.
• W2178270601 creator A5003016237 @default.
• W2178270601 creator A5003123045 @default.
• W2178270601 creator A5025551264 @default.
• W2178270601 creator A5029360035 @default.
• W2178270601 creator A5067096775 @default.
• W2178270601 creator A5074917608 @default.
• W2178270601 creator A5075240804 @default.
• W2178270601 creator A5079882763 @default.
• W2178270601 date "2015-11-20" @default.
• W2178270601 modified "2023-09-25" @default.
• W2178270601 title "Association of Estrogen Receptor Gene Polymorphisms and Primary Biliary Cirrhosis in a Chinese Population" @default.
• W2178270601 cites W1483301564 @default.
• W2178270601 cites W1690033343 @default.
• W2178270601 cites W180744667 @default.
• W2178270601 cites W1979994451 @default.
• W2178270601 cites W1980706562 @default.
• W2178270601 cites W1990477938 @default.
• W2178270601 cites W1991166786 @default.
• W2178270601 cites W1999074834 @default.
• W2178270601 cites W2002875738 @default.
• W2178270601 cites W2006493179 @default.
• W2178270601 cites W2025824197 @default.
• W2178270601 cites W2030480043 @default.
• W2178270601 cites W2040375465 @default.
• W2178270601 cites W2041619177 @default.
• W2178270601 cites W2051892110 @default.
• W2178270601 cites W2056946686 @default.
• W2178270601 cites W2065203592 @default.
• W2178270601 cites W2091482013 @default.
• W2178270601 cites W2113279182 @default.
• W2178270601 cites W2117328195 @default.
• W2178270601 cites W2118233109 @default.
• W2178270601 cites W2124782385 @default.
• W2178270601 cites W2134308617 @default.
• W2178270601 cites W2142376519 @default.
• W2178270601 cites W2143095600 @default.
• W2178270601 cites W2152758419 @default.
• W2178270601 cites W2349626546 @default.
• W2178270601 cites W2398182890 @default.
• W2178270601 cites W35381647 @default.
• W2178270601 cites W4292540530 @default.
• W2178270601 doi "https://doi.org/10.4103/0366-6999.168964" @default.
• W2178270601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4795257" @default.
• W2178270601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26608979" @default.
• W2178270601 hasPublicationYear "2015" @default.
• W2178270601 type Work @default.
• W2178270601 sameAs 2178270601 @default.
• W2178270601 citedByCount "5" @default.
• W2178270601 countsByYear W21782706012016 @default.
• W2178270601 countsByYear W21782706012018 @default.
• W2178270601 countsByYear W21782706012022 @default.
• W2178270601 countsByYear W21782706012023 @default.
• W2178270601 crossrefType "journal-article" @default.
• W2178270601 hasAuthorship W2178270601A5003016237 @default.
• W2178270601 hasAuthorship W2178270601A5003123045 @default.
• W2178270601 hasAuthorship W2178270601A5025551264 @default.
• W2178270601 hasAuthorship W2178270601A5029360035 @default.
• W2178270601 hasAuthorship W2178270601A5067096775 @default.
• W2178270601 hasAuthorship W2178270601A5074917608 @default.
• W2178270601 hasAuthorship W2178270601A5075240804 @default.
• W2178270601 hasAuthorship W2178270601A5079882763 @default.
• W2178270601 hasBestOaLocation W21782706011 @default.
• W2178270601 hasConcept C104317684 @default.
• W2178270601 hasConcept C121608353 @default.
• W2178270601 hasConcept C126322002 @default.
• W2178270601 hasConcept C134018914 @default.
• W2178270601 hasConcept C135763542 @default.
• W2178270601 hasConcept C153209595 @default.
• W2178270601 hasConcept C156957248 @default.
• W2178270601 hasConcept C172313692 @default.
• W2178270601 hasConcept C180754005 @default.
• W2178270601 hasConcept C197754878 @default.
• W2178270601 hasConcept C2780366471 @default.
• W2178270601 hasConcept C2908647359 @default.
• W2178270601 hasConcept C530470458 @default.
• W2178270601 hasConcept C54355233 @default.
• W2178270601 hasConcept C71924100 @default.
• W2178270601 hasConcept C84606932 @default.
• W2178270601 hasConcept C86803240 @default.
• W2178270601 hasConcept C90924648 @default.
• W2178270601 hasConcept C99454951 @default.
• W2178270601 hasConceptScore W2178270601C104317684 @default.
• W2178270601 hasConceptScore W2178270601C121608353 @default.
• W2178270601 hasConceptScore W2178270601C126322002 @default.
• W2178270601 hasConceptScore W2178270601C134018914 @default.
• W2178270601 hasConceptScore W2178270601C135763542 @default.
• W2178270601 hasConceptScore W2178270601C153209595 @default.
• W2178270601 hasConceptScore W2178270601C156957248 @default.
• W2178270601 hasConceptScore W2178270601C172313692 @default.
• W2178270601 hasConceptScore W2178270601C180754005 @default.
• W2178270601 hasConceptScore W2178270601C197754878 @default.
• W2178270601 hasConceptScore W2178270601C2780366471 @default.
• W2178270601 hasConceptScore W2178270601C2908647359 @default.
• W2178270601 hasConceptScore W2178270601C530470458 @default.
• W2178270601 hasConceptScore W2178270601C54355233 @default.
• W2178270601 hasConceptScore W2178270601C71924100 @default.

• next