FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2178318346> ?p ?o ?g. }

• W2178318346 abstract "BACKGROUND: Radiation exposure can lead to detrimental effects in skin microcirculation. The precise relationship between radiation dose received and its effect on cutaneous perfusion still remains controversial. Previously, we have shown that hyperspectral imaging (HSI) is able to demonstrate long-term reductions in cutaneous perfusion secondary to chronic microvascular injury. This study characterizes the changes in skin microcirculation in response to varying doses of ionizing radiation and investigates these microcirculatory changes as a possible early non-invasive biomarker that may correlate with the extent of long-term microvascular damage. METHODS: Immunocompetent hairless mice (n=66) were exposed to single fractions of superficial beta-irradiation in doses of 0, 5, 10, 20, 35, or 50 Gy. A HSI device was utilized to measure deoxygenated hemoglobin levels in irradiated and control areas. HSI measurements were performed at baseline before radiation exposure and for the first three days post-irradiation. Maximum macroscopic skin reactions were graded, and histological assessment of cutaneous microvascular densities at four weeks post-irradiation was performed in harvested tissue by CD31 immunohistochemistry. RESULTS: CD31 immunohistochemistry demonstrated a significant correlation (r=0.90, p<0.0001) between dose and vessel density reduction at four weeks. Using HSI analysis, early changes in deoxygenated hemoglobin levels were observed during the first three days post-irradiation in all groups. These deoxygenated hemoglobin changes varied proportionally with dose (r=0.98, p<0.0001) and skin reactions (r=0.98, p<0.0001). There was a highly significant correlation (r= 0.91, p<0.0001) between these early changes in deoxygenated hemoglobin and late vascular injury severity assessed at the end of four weeks. CONCLUSIONS: Radiation dose is directly correlated with cutaneous microvascular injury severity at four weeks in our model. Early post-exposure measurement of cutaneous deoxygenated hemoglobin levels may be a useful biomarker for radiation dose reconstruction and predictor for chronic microvascular injury." @default.
• W2178318346 created "2016-06-24" @default.
• W2178318346 creator A5006774791 @default.
• W2178318346 creator A5025717741 @default.
• W2178318346 creator A5043674846 @default.
• W2178318346 creator A5067417593 @default.
• W2178318346 creator A5068254762 @default.
• W2178318346 creator A5084223845 @default.
• W2178318346 creator A5088885717 @default.
• W2178318346 creator A5091179594 @default.
• W2178318346 creator A5091275868 @default.
• W2178318346 date "2015-10-26" @default.
• W2178318346 modified "2023-09-30" @default.
• W2178318346 title "Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage" @default.
• W2178318346 cites W188478163 @default.
• W2178318346 cites W1972999763 @default.
• W2178318346 cites W1989241281 @default.
• W2178318346 cites W2001210689 @default.
• W2178318346 cites W2005644102 @default.
• W2178318346 cites W2008427204 @default.
• W2178318346 cites W2008916276 @default.
• W2178318346 cites W2009031123 @default.
• W2178318346 cites W2024639260 @default.
• W2178318346 cites W2028452489 @default.
• W2178318346 cites W2040597079 @default.
• W2178318346 cites W2041562797 @default.
• W2178318346 cites W2042563169 @default.
• W2178318346 cites W2048651133 @default.
• W2178318346 cites W2050523292 @default.
• W2178318346 cites W2055840702 @default.
• W2178318346 cites W2063372774 @default.
• W2178318346 cites W2073165090 @default.
• W2178318346 cites W2088894030 @default.
• W2178318346 cites W2090892743 @default.
• W2178318346 cites W2095416751 @default.
• W2178318346 cites W2101002358 @default.
• W2178318346 cites W2112413671 @default.
• W2178318346 cites W2126683897 @default.
• W2178318346 cites W2138605058 @default.
• W2178318346 cites W2150160398 @default.
• W2178318346 cites W2335136973 @default.
• W2178318346 cites W2429926235 @default.
• W2178318346 cites W70122728 @default.
• W2178318346 doi "https://doi.org/10.3389/fonc.2015.00232" @default.
• W2178318346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4620692" @default.
• W2178318346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26579490" @default.
• W2178318346 hasPublicationYear "2015" @default.
• W2178318346 type Work @default.
• W2178318346 sameAs 2178318346 @default.
• W2178318346 citedByCount "10" @default.
• W2178318346 countsByYear W21783183462016 @default.
• W2178318346 countsByYear W21783183462017 @default.
• W2178318346 countsByYear W21783183462019 @default.
• W2178318346 countsByYear W21783183462020 @default.
• W2178318346 countsByYear W21783183462021 @default.
• W2178318346 countsByYear W21783183462022 @default.
• W2178318346 countsByYear W21783183462023 @default.
• W2178318346 crossrefType "journal-article" @default.
• W2178318346 hasAuthorship W2178318346A5006774791 @default.
• W2178318346 hasAuthorship W2178318346A5025717741 @default.
• W2178318346 hasAuthorship W2178318346A5043674846 @default.
• W2178318346 hasAuthorship W2178318346A5067417593 @default.
• W2178318346 hasAuthorship W2178318346A5068254762 @default.
• W2178318346 hasAuthorship W2178318346A5084223845 @default.
• W2178318346 hasAuthorship W2178318346A5088885717 @default.
• W2178318346 hasAuthorship W2178318346A5091179594 @default.
• W2178318346 hasAuthorship W2178318346A5091275868 @default.
• W2178318346 hasBestOaLocation W21783183461 @default.
• W2178318346 hasConcept C111337013 @default.
• W2178318346 hasConcept C121332964 @default.
• W2178318346 hasConcept C126322002 @default.
• W2178318346 hasConcept C12722491 @default.
• W2178318346 hasConcept C142724271 @default.
• W2178318346 hasConcept C146957229 @default.
• W2178318346 hasConcept C18231593 @default.
• W2178318346 hasConcept C185544564 @default.
• W2178318346 hasConcept C185592680 @default.
• W2178318346 hasConcept C204232928 @default.
• W2178318346 hasConcept C2776436680 @default.
• W2178318346 hasConcept C2778917026 @default.
• W2178318346 hasConcept C2778939058 @default.
• W2178318346 hasConcept C2781197716 @default.
• W2178318346 hasConcept C2910876585 @default.
• W2178318346 hasConcept C2989005 @default.
• W2178318346 hasConcept C55493867 @default.
• W2178318346 hasConcept C71924100 @default.
• W2178318346 hasConceptScore W2178318346C111337013 @default.
• W2178318346 hasConceptScore W2178318346C121332964 @default.
• W2178318346 hasConceptScore W2178318346C126322002 @default.
• W2178318346 hasConceptScore W2178318346C12722491 @default.
• W2178318346 hasConceptScore W2178318346C142724271 @default.
• W2178318346 hasConceptScore W2178318346C146957229 @default.
• W2178318346 hasConceptScore W2178318346C18231593 @default.
• W2178318346 hasConceptScore W2178318346C185544564 @default.
• W2178318346 hasConceptScore W2178318346C185592680 @default.
• W2178318346 hasConceptScore W2178318346C204232928 @default.
• W2178318346 hasConceptScore W2178318346C2776436680 @default.
• W2178318346 hasConceptScore W2178318346C2778917026 @default.
• W2178318346 hasConceptScore W2178318346C2778939058 @default.
• W2178318346 hasConceptScore W2178318346C2781197716 @default.

• next