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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2178362803> ?p ?o ?g. }

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• W2178362803 abstract "A novel class of HCV NS5B RNA dependent RNA polymerase inhibitors containing 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole scaffolds were designed and synthesized. Optimization of the aromatic region showed preference for 5,8-disubstitution pattern in both the scaffolds examined while favoring the n-propyl moiety for the C-1 position. 1,2,3,4-tetrahydro-cyclopenta[b]indole scaffold was slightly more potent than the corresponding 2,3,4,9-tetrahydro-1H-carbazole and analogue 36 displayed an IC50 of 550 nM against HCV NS5B enzyme." @default.
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• W2178362803 date "2006-05-01" @default.
• W2178362803 modified "2023-09-26" @default.
• W2178362803 title "Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase" @default.
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• W2178362803 doi "https://doi.org/10.1016/j.bmcl.2006.01.105" @default.
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