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• W2178367062 abstract "Traumatic brain injury (TBI) is a significant and enduring health care issue with limited treatment options. While several pre-clinical therapeutic approaches have led to enhanced motor and/or cognitive performance, the benefits of these treatments have not translated to the clinic. One plausible explanation is that the therapies may not have been rigorously evaluated, thus rendering the bench-to-bedside leap premature and subsequently unsuccessful. An approach that has undergone considerable empirical research after TBI is pharmacological targeting of 5-HT1A receptors with agonists such as repinotan HCl, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), and buspirone. The goal of this review is to integrate and interpret the findings from a series of studies that evaluated the efficacy of 5-HT1A receptor agonists on functional, histological, and molecular outcome after acquired brain injury. The overwhelming consensus of this exhaustive review is that a decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma. This article is part of a Special Issue entitled SI:Brain injury and recovery." @default.
• W2178367062 created "2016-06-24" @default.
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• W2178367062 date "2016-06-01" @default.
• W2178367062 modified "2023-10-18" @default.
• W2178367062 title "5-hydroxytryptamine 1A (5-HT 1A ) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma" @default.
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• W2178367062 doi "https://doi.org/10.1016/j.brainres.2015.11.026" @default.
• W2178367062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4870091" @default.
• W2178367062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26612522" @default.
• W2178367062 hasPublicationYear "2016" @default.
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