Matches in SemOpenAlex for { <https://semopenalex.org/work/W2178394811> ?p ?o ?g. }
- W2178394811 endingPage "626" @default.
- W2178394811 startingPage "615" @default.
- W2178394811 abstract "Non-alcoholic steatohepatitis (NASH), a hepatic manifestation of metabolic syndrome, is a major cause of morbidity and healthcare burden worldwide. While the molecular pathogenesis of NASH remains unclear and therapeutic options are limited, inflammation is recognized as an essential factor for NASH development. Factors that link NASH to inflammation are macrophages and their secreted cytokines.This review summarizes the current knowledge of macrophage-mediated molecular pathways in NASH to shed insights on potential pharmacotherapeutic applications.Macrophages are not only known for their role of phagocytosis in innate immunity, but also for both extrinsic and intrinsic regulation of inflammatory functions of many cytokines. Recent advances have revealed the effects of macrophage recruitment and polarization on the development of NASH. We and others have shown that the proliferation of hepatic macrophages and the subsequent production of pro-inflammatory cytokines initiates inflammatory cascades, orchestrates activities of transcription factors involved in lipid metabolism/translocation, and modulates programmed cell death. Together, these findings support the pathophysiological role of macrophages in the pathogenesis of NASH. Thus, evaluating potential therapeutic targets against the infiltration and/or polarization of specific macrophage subtypes is of clinical interest for alleviation of early-stage NASH, with the goal of halting disease progression." @default.
- W2178394811 created "2016-06-24" @default.
- W2178394811 creator A5007585753 @default.
- W2178394811 creator A5031804038 @default.
- W2178394811 creator A5052910292 @default.
- W2178394811 creator A5065143102 @default.
- W2178394811 date "2016-01-22" @default.
- W2178394811 modified "2023-10-14" @default.
- W2178394811 title "Pathophysiological mechanisms and therapeutic potentials of macrophages in non-alcoholic steatohepatitis" @default.
- W2178394811 cites W1585390661 @default.
- W2178394811 cites W1600798832 @default.
- W2178394811 cites W1750257611 @default.
- W2178394811 cites W1898569975 @default.
- W2178394811 cites W1968393209 @default.
- W2178394811 cites W1969682450 @default.
- W2178394811 cites W1970136916 @default.
- W2178394811 cites W1974488167 @default.
- W2178394811 cites W1979145606 @default.
- W2178394811 cites W1980566948 @default.
- W2178394811 cites W1987769185 @default.
- W2178394811 cites W1988981256 @default.
- W2178394811 cites W1993384072 @default.
- W2178394811 cites W1993458861 @default.
- W2178394811 cites W1994378435 @default.
- W2178394811 cites W1995986855 @default.
- W2178394811 cites W2005002911 @default.
- W2178394811 cites W2005177004 @default.
- W2178394811 cites W2005573382 @default.
- W2178394811 cites W2006999442 @default.
- W2178394811 cites W2008162733 @default.
- W2178394811 cites W2008214282 @default.
- W2178394811 cites W2010101404 @default.
- W2178394811 cites W2011709384 @default.
- W2178394811 cites W2018251493 @default.
- W2178394811 cites W2019646105 @default.
- W2178394811 cites W2019694067 @default.
- W2178394811 cites W2021607133 @default.
- W2178394811 cites W2024639496 @default.
- W2178394811 cites W2025139842 @default.
- W2178394811 cites W2026927520 @default.
- W2178394811 cites W2027234413 @default.
- W2178394811 cites W2028536701 @default.
- W2178394811 cites W2029157606 @default.
- W2178394811 cites W2036063346 @default.
- W2178394811 cites W2036409124 @default.
- W2178394811 cites W2042981158 @default.
- W2178394811 cites W2044274736 @default.
- W2178394811 cites W2048511851 @default.
- W2178394811 cites W2052497750 @default.
- W2178394811 cites W2056540147 @default.
- W2178394811 cites W2056908987 @default.
- W2178394811 cites W2058601621 @default.
- W2178394811 cites W2060388798 @default.
- W2178394811 cites W2061030289 @default.
- W2178394811 cites W2064358616 @default.
- W2178394811 cites W2064431177 @default.
- W2178394811 cites W2065612971 @default.
- W2178394811 cites W2069690908 @default.
- W2178394811 cites W2070690965 @default.
- W2178394811 cites W2070855360 @default.
- W2178394811 cites W2071908194 @default.
- W2178394811 cites W2073654211 @default.
- W2178394811 cites W2076062022 @default.
- W2178394811 cites W2076244923 @default.
- W2178394811 cites W2078009343 @default.
- W2178394811 cites W2082812721 @default.
- W2178394811 cites W2084589154 @default.
- W2178394811 cites W2084722601 @default.
- W2178394811 cites W2085390667 @default.
- W2178394811 cites W2087983261 @default.
- W2178394811 cites W2089907961 @default.
- W2178394811 cites W2092631819 @default.
- W2178394811 cites W2093222101 @default.
- W2178394811 cites W2093907771 @default.
- W2178394811 cites W2107683043 @default.
- W2178394811 cites W2114846722 @default.
- W2178394811 cites W2115412214 @default.
- W2178394811 cites W2117407599 @default.
- W2178394811 cites W2118278569 @default.
- W2178394811 cites W2119863741 @default.
- W2178394811 cites W2123807183 @default.
- W2178394811 cites W2127187069 @default.
- W2178394811 cites W2130365746 @default.
- W2178394811 cites W2131111733 @default.
- W2178394811 cites W2131750038 @default.
- W2178394811 cites W2133644385 @default.
- W2178394811 cites W2135810789 @default.
- W2178394811 cites W2136239966 @default.
- W2178394811 cites W2136547076 @default.
- W2178394811 cites W2138102919 @default.
- W2178394811 cites W2138774651 @default.
- W2178394811 cites W2138915349 @default.
- W2178394811 cites W2142242761 @default.
- W2178394811 cites W2148179987 @default.
- W2178394811 cites W2150383835 @default.
- W2178394811 cites W2156414024 @default.
- W2178394811 cites W2161179853 @default.
- W2178394811 cites W2162166699 @default.