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• W21784148 abstract "The prime objective of intensive care is to ensure maintenance of normal physiological function. Since this is mainly dependent on the ability of the circulation to deliver adequate amounts of oxygen to the mitochondria of tissue where the respiratory chain produces high-energy phosphate compounds, the availability of techniques for the monitoring of oxygen transport to tissue are essential for intensive care of the critically ill patient. Measurement of blood or respiration gases can supply important information concerning major changes in the patient’s oxygen status, but information about the local oxygenation of tissue is also needed, since values of local oxygen supply and demand can be at great variance with the values measured centrally. Furthermore, techniques for determination of the function (or dysfunction) of local regulatory mechanisms at the microcirculatory or even at the intramitochondrial level could greatly increase clinical insight into disease progress attributable to tissue hypoxia. Such information is also needed to find out whether correction of systemic parameters such as blood pressure and cardiac output are also having the desired effect at the microcirculatory and intracellular level." @default.
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• W21784148 date "1991-01-01" @default.
• W21784148 modified "2023-09-23" @default.
• W21784148 title "Optical Spectroscopy for the Measurement of Tissue Hypoxia" @default.
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• W21784148 doi "https://doi.org/10.1007/978-3-642-84423-2_19" @default.
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