Matches in SemOpenAlex for { <https://semopenalex.org/work/W2178497680> ?p ?o ?g. }
- W2178497680 endingPage "E873" @default.
- W2178497680 startingPage "E861" @default.
- W2178497680 abstract "Endoplasmic reticulum (ER) stress and caspase 8-dependent apoptosis are two interlinked causal events in maternal diabetes-induced neural tube defects (NTDs). The inositol-requiring enzyme 1α (IRE1α) signalosome mediates the proapoptotic effect of ER stress. Diabetes increases tumor necrosis factor receptor type 1R-associated death domain (TRADD) expression. Here, we revealed two new unfolded protein response (UPR) regulators, TRADD and Fas-associated protein with death domain (FADD). TRADD interacted with both the IRE1α-TRAF2-ASK1 complex and FADD. In vivo overexpression of a FADD dominant negative (FADD-DN) mutant lacking the death effector domain disrupted diabetes-induced IRE1α signalosome and suppressed ER stress and caspase 8-dependent apoptosis, leading to NTD prevention. FADD-DN abrogated ER stress markers and blocked the JNK1/2-ASK1 pathway. Diabetes-induced mitochondrial translocation of proapoptotic Bcl-2 members mitochondrial dysfunction and caspase cleavage were also alleviated by FADD-DN. In vitro TRADD overexpression triggered UPR and ER stress before manifestation of caspase 3 and caspase 8 cleavage and apoptosis. FADD-DN overexpression repressed high glucose- or TRADD overexpression-induced IRE1α phosphorylation, its downstream proapoptotic kinase activation and endonuclease activities, and apoptosis. FADD-DN also attenuated tunicamycin-induced UPR and ER stress. These findings suggest that TRADD participates in the IRE1α signalosome and induces UPR and ER stress and that the association between TRADD and FADD is essential for diabetes- or high glucose-induced UPR and ER stress." @default.
- W2178497680 created "2016-06-24" @default.
- W2178497680 creator A5002661071 @default.
- W2178497680 creator A5035304169 @default.
- W2178497680 creator A5051526409 @default.
- W2178497680 creator A5063423811 @default.
- W2178497680 creator A5067535618 @default.
- W2178497680 creator A5086297696 @default.
- W2178497680 creator A5087785658 @default.
- W2178497680 date "2015-11-15" @default.
- W2178497680 modified "2023-10-16" @default.
- W2178497680 title "Dominant negative FADD dissipates the proapoptotic signalosome of the unfolded protein response in diabetic embryopathy" @default.
- W2178497680 cites W1492946553 @default.
- W2178497680 cites W1702242026 @default.
- W2178497680 cites W1968100018 @default.
- W2178497680 cites W1968328677 @default.
- W2178497680 cites W1979187096 @default.
- W2178497680 cites W1986737010 @default.
- W2178497680 cites W1987107175 @default.
- W2178497680 cites W1990136127 @default.
- W2178497680 cites W2002439304 @default.
- W2178497680 cites W2007065615 @default.
- W2178497680 cites W2023001000 @default.
- W2178497680 cites W2023895936 @default.
- W2178497680 cites W2025155323 @default.
- W2178497680 cites W2029501678 @default.
- W2178497680 cites W2032049429 @default.
- W2178497680 cites W2032514624 @default.
- W2178497680 cites W2036528355 @default.
- W2178497680 cites W2042500162 @default.
- W2178497680 cites W2046110868 @default.
- W2178497680 cites W2046671201 @default.
- W2178497680 cites W2051999773 @default.
- W2178497680 cites W2061015988 @default.
- W2178497680 cites W2080901528 @default.
- W2178497680 cites W2089198803 @default.
- W2178497680 cites W2094796994 @default.
- W2178497680 cites W2097348463 @default.
- W2178497680 cites W2099275774 @default.
- W2178497680 cites W2103596595 @default.
- W2178497680 cites W2106677353 @default.
- W2178497680 cites W2115205812 @default.
- W2178497680 cites W2121099849 @default.
- W2178497680 cites W2124792648 @default.
- W2178497680 cites W2126878764 @default.
- W2178497680 cites W2137719941 @default.
- W2178497680 cites W2146871627 @default.
- W2178497680 cites W2155945227 @default.
- W2178497680 cites W2159004116 @default.
- W2178497680 cites W2162969910 @default.
- W2178497680 cites W2168468414 @default.
- W2178497680 cites W2192080449 @default.
- W2178497680 doi "https://doi.org/10.1152/ajpendo.00215.2015" @default.
- W2178497680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4652069" @default.
- W2178497680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26419589" @default.
- W2178497680 hasPublicationYear "2015" @default.
- W2178497680 type Work @default.
- W2178497680 sameAs 2178497680 @default.
- W2178497680 citedByCount "16" @default.
- W2178497680 countsByYear W21784976802015 @default.
- W2178497680 countsByYear W21784976802016 @default.
- W2178497680 countsByYear W21784976802017 @default.
- W2178497680 countsByYear W21784976802018 @default.
- W2178497680 countsByYear W21784976802019 @default.
- W2178497680 countsByYear W21784976802020 @default.
- W2178497680 countsByYear W21784976802022 @default.
- W2178497680 crossrefType "journal-article" @default.
- W2178497680 hasAuthorship W2178497680A5002661071 @default.
- W2178497680 hasAuthorship W2178497680A5035304169 @default.
- W2178497680 hasAuthorship W2178497680A5051526409 @default.
- W2178497680 hasAuthorship W2178497680A5063423811 @default.
- W2178497680 hasAuthorship W2178497680A5067535618 @default.
- W2178497680 hasAuthorship W2178497680A5086297696 @default.
- W2178497680 hasAuthorship W2178497680A5087785658 @default.
- W2178497680 hasBestOaLocation W21784976801 @default.
- W2178497680 hasConcept C139447449 @default.
- W2178497680 hasConcept C158617107 @default.
- W2178497680 hasConcept C185592680 @default.
- W2178497680 hasConcept C190283241 @default.
- W2178497680 hasConcept C2776055636 @default.
- W2178497680 hasConcept C2776472363 @default.
- W2178497680 hasConcept C2779004061 @default.
- W2178497680 hasConcept C31573885 @default.
- W2178497680 hasConcept C48297814 @default.
- W2178497680 hasConcept C502942594 @default.
- W2178497680 hasConcept C55493867 @default.
- W2178497680 hasConcept C86803240 @default.
- W2178497680 hasConcept C95444343 @default.
- W2178497680 hasConcept C98424977 @default.
- W2178497680 hasConceptScore W2178497680C139447449 @default.
- W2178497680 hasConceptScore W2178497680C158617107 @default.
- W2178497680 hasConceptScore W2178497680C185592680 @default.
- W2178497680 hasConceptScore W2178497680C190283241 @default.
- W2178497680 hasConceptScore W2178497680C2776055636 @default.
- W2178497680 hasConceptScore W2178497680C2776472363 @default.
- W2178497680 hasConceptScore W2178497680C2779004061 @default.
- W2178497680 hasConceptScore W2178497680C31573885 @default.
- W2178497680 hasConceptScore W2178497680C48297814 @default.