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• W2178558875 abstract "2-aminoethylbenzofurans constitute a new class of H(3) antagonists that are more rotationally constrained than most previously reported H(3) antagonists. They retain high potency at human and rat receptors, with efficient CNS penetration observed in 35. The SAR of the basic amine moiety was compared in three different series of analogues. The greatest potency was found in analogues bearing a 2-methylpyrrolidine, a 2,5-dimethylpyrrolidine, or a 2,6-dimethylpiperidine." @default.
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• W2178558875 date "2004-02-01" @default.
• W2178558875 modified "2023-09-23" @default.
• W2178558875 title "A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans" @default.
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• W2178558875 doi "https://doi.org/10.1016/j.bmcl.2003.11.032" @default.
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