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- W2178618172 abstract "Biomarkers have become the focus of intense research in the field of amyotrophic lateral sclerosis (ALS), with the hope that they might aid therapy development efforts. Notwithstanding the discovery of many candidate biomarkers, none have yet emerged as validated tools for drug development. In this review we present a nuanced view of biomarkers based on the perspective of the Food and Drug Administration; highlight the distinction between discovery and validation; describe existing and emerging resources; review leading biological fluid-based, electrophysiological, and neuroimaging candidates relevant to therapy development efforts; discuss lessons learned from biomarker initiatives in related neurodegenerative diseases; and outline specific steps that we, as a field, might take to hasten the development and validation of biomarkers that will prove useful in enhancing efforts to develop effective treatments for ALS patients. Most important among these is the proposal to establish a federated ALS Biomarker Consortium in which all interested and willing stakeholders may participate with equal opportunity to contribute to the broader mission of biomarker development and validation." @default.
- W2178618172 created "2016-06-24" @default.
- W2178618172 creator A5001165676 @default.
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- W2178618172 creator A5057612738 @default.
- W2178618172 creator A5066422345 @default.
- W2178618172 creator A5087266520 @default.
- W2178618172 date "2015-12-29" @default.
- W2178618172 modified "2023-10-01" @default.
- W2178618172 title "ALS biomarkers for therapy development: State of the field and future directions" @default.
- W2178618172 cites W1137678651 @default.
- W2178618172 cites W1491453222 @default.
- W2178618172 cites W1558795029 @default.
- W2178618172 cites W1769539317 @default.
- W2178618172 cites W1792205889 @default.
- W2178618172 cites W1830634249 @default.
- W2178618172 cites W1878242548 @default.
- W2178618172 cites W1912693339 @default.
- W2178618172 cites W1934227857 @default.
- W2178618172 cites W1936370106 @default.
- W2178618172 cites W1965434700 @default.
- W2178618172 cites W1969387798 @default.
- W2178618172 cites W1971348077 @default.
- W2178618172 cites W1971782519 @default.
- W2178618172 cites W1972817980 @default.
- W2178618172 cites W1974382353 @default.
- W2178618172 cites W1975039972 @default.
- W2178618172 cites W1979539929 @default.
- W2178618172 cites W1981929653 @default.
- W2178618172 cites W1982957249 @default.
- W2178618172 cites W1984538960 @default.
- W2178618172 cites W1985582661 @default.
- W2178618172 cites W1986176703 @default.
- W2178618172 cites W1988861747 @default.
- W2178618172 cites W1992901878 @default.
- W2178618172 cites W1994661365 @default.
- W2178618172 cites W1996111658 @default.
- W2178618172 cites W1997874814 @default.
- W2178618172 cites W2000308123 @default.
- W2178618172 cites W2001477615 @default.
- W2178618172 cites W2002887379 @default.
- W2178618172 cites W2005143750 @default.
- W2178618172 cites W2005243883 @default.
- W2178618172 cites W2006507858 @default.
- W2178618172 cites W2007568107 @default.
- W2178618172 cites W2013488820 @default.
- W2178618172 cites W2019706623 @default.
- W2178618172 cites W2020279151 @default.
- W2178618172 cites W2026158140 @default.
- W2178618172 cites W2026863482 @default.
- W2178618172 cites W2030962150 @default.
- W2178618172 cites W2031518733 @default.
- W2178618172 cites W2032384212 @default.
- W2178618172 cites W2038735530 @default.
- W2178618172 cites W2039456249 @default.
- W2178618172 cites W2040358504 @default.
- W2178618172 cites W2040678584 @default.
- W2178618172 cites W2040753909 @default.
- W2178618172 cites W2046433440 @default.
- W2178618172 cites W2051387942 @default.
- W2178618172 cites W2054068057 @default.
- W2178618172 cites W2055538436 @default.
- W2178618172 cites W2059534047 @default.
- W2178618172 cites W2060378686 @default.
- W2178618172 cites W2060876918 @default.
- W2178618172 cites W2061418826 @default.
- W2178618172 cites W2062518684 @default.
- W2178618172 cites W2062714993 @default.
- W2178618172 cites W2063996210 @default.
- W2178618172 cites W2064490318 @default.
- W2178618172 cites W2068037239 @default.
- W2178618172 cites W2069171272 @default.
- W2178618172 cites W2072568832 @default.
- W2178618172 cites W2074830646 @default.
- W2178618172 cites W2076745180 @default.
- W2178618172 cites W2077234258 @default.
- W2178618172 cites W2077612318 @default.
- W2178618172 cites W2080763041 @default.
- W2178618172 cites W2082104197 @default.
- W2178618172 cites W2082397844 @default.
- W2178618172 cites W2082468728 @default.
- W2178618172 cites W2082822881 @default.
- W2178618172 cites W2083757931 @default.
- W2178618172 cites W2090624356 @default.
- W2178618172 cites W2092145129 @default.
- W2178618172 cites W2098540744 @default.
- W2178618172 cites W2099525821 @default.
- W2178618172 cites W2102734053 @default.
- W2178618172 cites W2105890305 @default.
- W2178618172 cites W2110198088 @default.
- W2178618172 cites W2110603456 @default.
- W2178618172 cites W2113362178 @default.
- W2178618172 cites W2114038592 @default.
- W2178618172 cites W2118235736 @default.
- W2178618172 cites W2119368143 @default.
- W2178618172 cites W2120259577 @default.