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- W2178701771 abstract "A powerful way to discover key genes with causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here we present high-resolution analyses of somatic copy-number alterations (SCNAs) from 3,131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across several cancer types, of which 122 cannot be explained by the presence of a known cancer target gene located within these regions. Several gene families are enriched among these regions of focal SCNA, including the BCL2 family of apoptosis regulators and the NF-kappaBeta pathway. We show that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival. Finally, we demonstrate that a large majority of SCNAs identified in individual cancer types are present in several cancer types." @default.
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- W2178701771 date "2010-02-01" @default.
- W2178701771 modified "2023-10-17" @default.
- W2178701771 title "The landscape of somatic copy-number alteration across human cancers" @default.
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- W2178701771 cites W2016548691 @default.
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- W2178701771 cites W2058656467 @default.
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- W2178701771 cites W2061308322 @default.
- W2178701771 cites W2062083469 @default.
- W2178701771 cites W2076020247 @default.
- W2178701771 cites W2078457332 @default.
- W2178701771 cites W2078951483 @default.
- W2178701771 cites W2100725331 @default.
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- W2178701771 cites W2122769974 @default.
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- W2178701771 cites W2154122181 @default.
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- W2178701771 hasPublicationYear "2010" @default.