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- W2178702966 abstract "Summary The theoretic basis and clinical usefulness of a number of liver function tests have been discussed. It is noteworthy that none of them measures the essential metabolic functions of the liver, such as deaminization of amino acids or the maintenance of blood sugar levels. Nothing has been said about the correlation of these tests with each other or with the histologic appearance of liver cells as shown by needle biopsy; actually, little correlation should be expected. The best of our tests are relatively crude; most of them are affected to some extent by extraneous factors and all are subject to laboratory error. The liver parenchyma has far too great a range of biologic activity to permit of any simple or easy approach. As Hanger 3 has pointed out, the hepatic parenchyma represents a barrier of cells which separate the vascular bed from the biliary system with a functional surface in direct contact with each. The activities of the liver which we attempt to determine depend upon the capacity of this barrier to maintain and interchange the metabolites in and with both compartments. Certain substances, ranging from complex bile pigments to water, are excreted into the bile spaces, whereas other metabolites such as sugar, fats and proteins are maintained at the opposite cell surface in equilibrium with the portal blood. It is not at all likely that such a complex system can be easily sampled by any process which we now recognize. However, enough is known about the results of liver function tests in liver disease to contribute a great deal to our clinical appraisal of a patient. As for the tests themselves, they have some serious limitations, and they are no more infallible than the people who use them." @default.
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- W2178702966 date "1958-04-01" @default.
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- W2178702966 title "Liver Function Tests and Their Interpretation" @default.
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- W2178702966 doi "https://doi.org/10.1016/s0016-5085(58)80052-9" @default.
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