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- W2178756449 abstract "Background/Aims: Pancreatic is the fourth most common cause of associated death worldwide with a five year survival rate less than 5%. The poor prognosis is mainly due to late presentation in 80% of patients and its drug resistant nature. Most diagnoses are made using contrast-enhanced computed-tomography (CT) or magnetic-resonance-imaging (MRI) which have a limited sensitivity between 76-86%. Iron oxide nanoparticles are increasingly used in the diagnostic imaging of cancer, due their ability to selectively target tumour cells thereby increasing image resolution. The aim of this study is to identify studies investigating the use of oxide nanoparticles in the diagnostic imaging of cancer. Methods: A systematic review was performed using PubMed for records up to 2015. Search terms used included iron oxide nanoparticles, pancreatic cancer and imaging.Results: A total of 16 studies were identified evaluating the use of oxide nanoparticles in the imaging of in-vitro and in in-vivo animal models. Eight of the studies evaluated the use of superparamagnetic-iron-oxide-nanoparticles (SPION), they showed SPION significantly decrease the T2 and T2* relaxation times of tumour tissue, providing a high sensitivity for MRI. Similar results were seen in eight studies that investigated the use of oxide nanoparticles conjugated to other molecules including gelatin, survivin, chemokine-receptor-4, silica-gold, endothelial-growth-factor-receptor, urokinase-receptor activator, Clostridium and a sonic-hedgehog target.Conclusion: Iron oxide nanoparticles in the form of SPION or conjugates are biocompatible and effective at targeting tumour cells and significantly attenuate MRI signals in T2-weighted images of cancers from a range of cell lines." @default.
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- W2178756449 date "2015-10-01" @default.
- W2178756449 modified "2023-09-26" @default.
- W2178756449 title "Emerging role of iron oxide nanoparticles in the diagnostic imaging of pancreatic cancer: a systematic review" @default.
- W2178756449 hasPublicationYear "2015" @default.
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