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• W2178760336 abstract "Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative pathogens. The compounds are also active against linezolid- and ciprofloxacin-resistant Staphylococcus aureus and Enterococcus faecium strains. The MOA for these new antimicrobials is consistent with a combination of protein synthesis and gyrase A/topoisomerase IV inhibition, with a structure-dependent degree of the contribution from each inhibitory mechanism." @default.
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• W2178760336 date "2003-12-01" @default.
• W2178760336 modified "2023-10-18" @default.
• W2178760336 title "Novel oxazolidinone–quinolone hybrid antimicrobials" @default.
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• W2178760336 doi "https://doi.org/10.1016/j.bmcl.2003.07.021" @default.
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