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- W2178847668 abstract "Fibrinogen can engage diverse receptors on vascular cells, including ICAM-1. We have investigated the effect of fibrinogen on the tyrosine phosphorylation of cortactin, a cytoskeletal protein in human saphenous vein endothelial cells (HSVECs). Incubation of HSVECs with fibrinogen (0-4 microM) caused a concentration-dependent increase in the tyrosine phosphorylation of cortactin. Fibrinogen (4 microM) and fibrinogen fragment D (4 microM) caused 250% and >450% increase in tyrosine phosphorylation of cortactin respectively, but fibrinogen fragment E (50 kDa form) was ineffective. Preincubation of HSVECs with soluble ICAM-1 attenuated the response to fibrinogen. At physiological concentrations fibrinogen binds to receptors (probably including ICAM-1) on HSVECs, to increase tyrosine phosphorylation of cortactin." @default.
- W2178847668 created "2016-06-24" @default.
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- W2178847668 date "2000-01-01" @default.
- W2178847668 modified "2023-09-26" @default.
- W2178847668 title "Interaction of Fibrinogen with Saphenous Vein Endothelial Cells Stimulates Tyrosine Phosphorylation of Cortactin" @default.
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- W2178847668 doi "https://doi.org/10.3109/10623320009072209" @default.
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