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- W21789834 abstract "Pneumocystis carinii and Toxoplasma gondii are the two major parasitic protozoan pathogens in the immunocompromised host. Both organisms cause latent infection in humans and many animals. Cats are the definitive hosts for toxoplasmosis; the animal vector for pneumocystis (if any) has not been defined. Toxoplasma is an obligate intracellular parasite, whereas the available evidence suggests that Pneumocystis carinii exists primarily extracellularly. In compromised hosts, pneumocystis infection usually involves only lungs, whereas toxoplasma causes a generalized infection with encephalitis being the principal clinical manifestation. Both types of infection are treated with combinations of folate antagonists (trimethoprim or pyrimethamine with sulfonamide). Both parasites are associated with cytomegalovirus infection in immunosuppressed hosts, an association which may be due to symbiosis between parasites, or to an additive immunosuppressive effect of dual infection on the hosts." @default.
- W21789834 created "2016-06-24" @default.
- W21789834 creator A5055389140 @default.
- W21789834 creator A5090093609 @default.
- W21789834 date "1979-01-01" @default.
- W21789834 modified "2023-09-27" @default.
- W21789834 title "Pneumocystis carinii, Toxoplasma gondii, Cytomegalovirus and the compromised host." @default.
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- W21789834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1238480" @default.
- W21789834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/217182" @default.
- W21789834 hasPublicationYear "1979" @default.
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