FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179038677> ?p ?o ?g. }

• W2179038677 endingPage "29" @default.
• W2179038677 startingPage "21" @default.
• W2179038677 abstract "Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax. Yet its mechanism of action is still poorly understood. In this study, we used the yeast Saccharomyces cerevisiae model to help uncover the mode of action of primaquine. We found that the growth inhibitory effect of primaquine was restricted to cells that relied on respiratory function to proliferate and that deletion of SOD2 encoding the mitochondrial superoxide dismutase severely increased its effect, which can be countered by the overexpression of AIM32 and MCR1 encoding mitochondrial enzymes involved in the response to oxidative stress. This indicated that ROS produced by respiratory activity had a key role in primaquine-induced growth defect. We observed that Δsod2 cells treated with primaquine displayed a severely decreased activity of aconitase that contains a Fe–S cluster notoriously sensitive to oxidative damage. We also showed that in vitro exposure to primaquine impaired the activity of purified aconitase and accelerated the turnover of the Fe–S cluster of the essential protein Rli1. It is suggested that ROS-labile Fe–S groups are the primary targets of primaquine. Aconitase activity is known to be essential at certain life-cycle stages of the malaria parasite. Thus primaquine-induced damage of its labile Fe–S cluster – and of other ROS-sensitive enzymes – could inhibit parasite development." @default.
• W2179038677 created "2016-06-24" @default.
• W2179038677 creator A5020049532 @default.
• W2179038677 creator A5029129605 @default.
• W2179038677 creator A5040239597 @default.
• W2179038677 creator A5041045348 @default.
• W2179038677 creator A5043578087 @default.
• W2179038677 creator A5059995717 @default.
• W2179038677 creator A5065856473 @default.
• W2179038677 creator A5071461810 @default.
• W2179038677 creator A5079591293 @default.
• W2179038677 creator A5089512446 @default.
• W2179038677 date "2016-04-01" @default.
• W2179038677 modified "2023-10-12" @default.
• W2179038677 title "The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth" @default.
• W2179038677 cites W1498131095 @default.
• W2179038677 cites W1509127316 @default.
• W2179038677 cites W1576198188 @default.
• W2179038677 cites W1792666615 @default.
• W2179038677 cites W1940436875 @default.
• W2179038677 cites W1965489528 @default.
• W2179038677 cites W1969490516 @default.
• W2179038677 cites W1973828942 @default.
• W2179038677 cites W1990059136 @default.
• W2179038677 cites W1990264387 @default.
• W2179038677 cites W1993743888 @default.
• W2179038677 cites W2004073746 @default.
• W2179038677 cites W2009631075 @default.
• W2179038677 cites W2010940726 @default.
• W2179038677 cites W2016759257 @default.
• W2179038677 cites W2020569812 @default.
• W2179038677 cites W2020755315 @default.
• W2179038677 cites W2029312295 @default.
• W2179038677 cites W2029342214 @default.
• W2179038677 cites W2029772331 @default.
• W2179038677 cites W2029867893 @default.
• W2179038677 cites W2031257231 @default.
• W2179038677 cites W2031673075 @default.
• W2179038677 cites W2032119559 @default.
• W2179038677 cites W2042535759 @default.
• W2179038677 cites W2047761142 @default.
• W2179038677 cites W2051105907 @default.
• W2179038677 cites W2051180136 @default.
• W2179038677 cites W2060517884 @default.
• W2179038677 cites W2063638273 @default.
• W2179038677 cites W2075614651 @default.
• W2179038677 cites W2080138031 @default.
• W2179038677 cites W2086807456 @default.
• W2179038677 cites W2087293823 @default.
• W2179038677 cites W2091684277 @default.
• W2179038677 cites W2093173456 @default.
• W2179038677 cites W2093905380 @default.
• W2179038677 cites W2097951502 @default.
• W2179038677 cites W2104386816 @default.
• W2179038677 cites W2114443210 @default.
• W2179038677 cites W2118103211 @default.
• W2179038677 cites W2137062868 @default.
• W2179038677 cites W2137952006 @default.
• W2179038677 cites W2143552714 @default.
• W2179038677 cites W2147627829 @default.
• W2179038677 cites W2153544371 @default.
• W2179038677 cites W2160455928 @default.
• W2179038677 cites W2165988320 @default.
• W2179038677 cites W2166265751 @default.
• W2179038677 cites W2167970645 @default.
• W2179038677 cites W2395095896 @default.
• W2179038677 cites W2399698722 @default.
• W2179038677 cites W274585343 @default.
• W2179038677 cites W4293087377 @default.
• W2179038677 cites W4300670732 @default.
• W2179038677 doi "https://doi.org/10.1016/j.redox.2015.10.008" @default.
• W2179038677 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4683384" @default.
• W2179038677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26629948" @default.
• W2179038677 hasPublicationYear "2016" @default.
• W2179038677 type Work @default.
• W2179038677 sameAs 2179038677 @default.
• W2179038677 citedByCount "26" @default.
• W2179038677 countsByYear W21790386772016 @default.
• W2179038677 countsByYear W21790386772017 @default.
• W2179038677 countsByYear W21790386772018 @default.
• W2179038677 countsByYear W21790386772019 @default.
• W2179038677 countsByYear W21790386772020 @default.
• W2179038677 countsByYear W21790386772021 @default.
• W2179038677 countsByYear W21790386772022 @default.
• W2179038677 countsByYear W21790386772023 @default.
• W2179038677 crossrefType "journal-article" @default.
• W2179038677 hasAuthorship W2179038677A5020049532 @default.
• W2179038677 hasAuthorship W2179038677A5029129605 @default.
• W2179038677 hasAuthorship W2179038677A5040239597 @default.
• W2179038677 hasAuthorship W2179038677A5041045348 @default.
• W2179038677 hasAuthorship W2179038677A5043578087 @default.
• W2179038677 hasAuthorship W2179038677A5059995717 @default.
• W2179038677 hasAuthorship W2179038677A5065856473 @default.
• W2179038677 hasAuthorship W2179038677A5071461810 @default.
• W2179038677 hasAuthorship W2179038677A5079591293 @default.
• W2179038677 hasAuthorship W2179038677A5089512446 @default.
• W2179038677 hasBestOaLocation W21790386771 @default.
• W2179038677 hasConcept C181199279 @default.

• next