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- W2179043943 abstract "A novel 15-deoxy-15,15-difluoro-prostaglandin(PG)F2α derivative 6 (AFP-168) has been synthesized from the Corey aldehyde in six steps. A key aspect of this route is difluorination of an enone and a stereoselective Wittig reaction. The compound shows high affinity to the FP receptor and potent activities for an anti-glaucoma agent." @default.
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- W2179043943 date "2004-02-01" @default.
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- W2179043943 title "Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: a novel 15-deoxy-15,15-difluoroprostaglandin F 2α derivative" @default.
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- W2179043943 doi "https://doi.org/10.1016/j.tetlet.2003.12.029" @default.
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