FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179129168> ?p ?o ?g. }

• W2179129168 abstract "High grade serous ovarian cancer is characterised by high initial response to chemotherapy but poor outcome in the long term due to acquired resistance. One of the main genetic features of this disease is TP53 mutation. The majority of TP53 mutated tumors harbor missense mutations in this gene, correlated with p53 accumulation. TP53 null tumors constitute a specific subgroup characterised by nonsense, frameshift or splice-site mutations associated to complete absence of p53 expression. Different studies show that this kind of tumors may have a worse prognosis than other TP53 mutated HGSC.In this study, we sought to characterise the intra-tumor heterogeneity of a TP53 null HGSC consisting of six primary tumor samples, two intra-pelvic and four extra-pelvic recurrences using exome sequencing and comparative genome hybridisation.Significant heterogeneity was found among the different tumor samples, both at the mutational and copy number levels. Exome sequencing identified 102 variants, of which only 42 were common to all three samples; whereas 7 of the 18 copy number changes found by CGH analysis were presented in all samples. Sanger validation of 20 variants found by exome sequencing in additional regions of the primary tumor and the recurrence allowed us to establish a sequence of the tumor clonal evolution, identifying those populations that most likely gave rise to recurrences and genes potentially involved in this process, like GPNMB and TFDP1. Using functional annotation and network analysis, we identified those biological functions most significantly altered in this tumor. Remarkably, unexpected functions such as microtubule-based movement and lipid metabolism emerged as important for tumor development and progression, suggesting its potential interest as therapeutic targets.Altogether, our results shed light on the clonal evolution of the distinct tumor regions identifying the most aggressive subpopulations and at least some of the genes that may be implicated in its progression and recurrence, and highlights the importance of considering intra-tumor heterogeneity when carrying out genetic and genomic studies, especially when these are aimed to diagnostic procedures or to uncover possible therapeutic strategies." @default.
• W2179129168 created "2016-06-24" @default.
• W2179129168 creator A5007606531 @default.
• W2179129168 creator A5012705284 @default.
• W2179129168 creator A5045516558 @default.
• W2179129168 creator A5058485099 @default.
• W2179129168 creator A5059058878 @default.
• W2179129168 creator A5061258630 @default.
• W2179129168 creator A5064332999 @default.
• W2179129168 creator A5069047495 @default.
• W2179129168 creator A5081288223 @default.
• W2179129168 date "2015-11-30" @default.
• W2179129168 modified "2023-10-18" @default.
• W2179129168 title "Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression" @default.
• W2179129168 cites W1487410601 @default.
• W2179129168 cites W1550376883 @default.
• W2179129168 cites W1759080653 @default.
• W2179129168 cites W1967952823 @default.
• W2179129168 cites W1968046362 @default.
• W2179129168 cites W1968901807 @default.
• W2179129168 cites W1976512618 @default.
• W2179129168 cites W1985018324 @default.
• W2179129168 cites W1985382542 @default.
• W2179129168 cites W1987507232 @default.
• W2179129168 cites W1997144017 @default.
• W2179129168 cites W2011254357 @default.
• W2179129168 cites W2015087800 @default.
• W2179129168 cites W2025119755 @default.
• W2179129168 cites W2025683553 @default.
• W2179129168 cites W2026813872 @default.
• W2179129168 cites W2029893817 @default.
• W2179129168 cites W2033737920 @default.
• W2179129168 cites W2040522646 @default.
• W2179129168 cites W2042484101 @default.
• W2179129168 cites W2051511587 @default.
• W2179129168 cites W2054666781 @default.
• W2179129168 cites W2054711461 @default.
• W2179129168 cites W2059145105 @default.
• W2179129168 cites W2067480918 @default.
• W2179129168 cites W2072455059 @default.
• W2179129168 cites W2074450438 @default.
• W2179129168 cites W2089477889 @default.
• W2179129168 cites W2095911832 @default.
• W2179129168 cites W2108541786 @default.
• W2179129168 cites W2120588059 @default.
• W2179129168 cites W2123696077 @default.
• W2179129168 cites W2126087169 @default.
• W2179129168 cites W2127543246 @default.
• W2179129168 cites W2127981150 @default.
• W2179129168 cites W2133465414 @default.
• W2179129168 cites W2138601221 @default.
• W2179129168 cites W2141211636 @default.
• W2179129168 cites W2149541861 @default.
• W2179129168 cites W2150667790 @default.
• W2179129168 cites W2155142785 @default.
• W2179129168 cites W2155943701 @default.
• W2179129168 cites W2156773126 @default.
• W2179129168 cites W2158217645 @default.
• W2179129168 cites W2161701941 @default.
• W2179129168 cites W2165440647 @default.
• W2179129168 cites W2315535178 @default.
• W2179129168 cites W2335222918 @default.
• W2179129168 doi "https://doi.org/10.1186/s12885-015-1952-z" @default.
• W2179129168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4666042" @default.
• W2179129168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26620706" @default.
• W2179129168 hasPublicationYear "2015" @default.
• W2179129168 type Work @default.
• W2179129168 sameAs 2179129168 @default.
• W2179129168 citedByCount "16" @default.
• W2179129168 countsByYear W21791291682017 @default.
• W2179129168 countsByYear W21791291682018 @default.
• W2179129168 countsByYear W21791291682019 @default.
• W2179129168 countsByYear W21791291682020 @default.
• W2179129168 countsByYear W21791291682021 @default.
• W2179129168 countsByYear W21791291682022 @default.
• W2179129168 countsByYear W21791291682023 @default.
• W2179129168 crossrefType "journal-article" @default.
• W2179129168 hasAuthorship W2179129168A5007606531 @default.
• W2179129168 hasAuthorship W2179129168A5012705284 @default.
• W2179129168 hasAuthorship W2179129168A5045516558 @default.
• W2179129168 hasAuthorship W2179129168A5058485099 @default.
• W2179129168 hasAuthorship W2179129168A5059058878 @default.
• W2179129168 hasAuthorship W2179129168A5061258630 @default.
• W2179129168 hasAuthorship W2179129168A5064332999 @default.
• W2179129168 hasAuthorship W2179129168A5069047495 @default.
• W2179129168 hasAuthorship W2179129168A5081288223 @default.
• W2179129168 hasBestOaLocation W21791291681 @default.
• W2179129168 hasConcept C104317684 @default.
• W2179129168 hasConcept C10590036 @default.
• W2179129168 hasConcept C121608353 @default.
• W2179129168 hasConcept C127716648 @default.
• W2179129168 hasConcept C150173356 @default.
• W2179129168 hasConcept C16671776 @default.
• W2179129168 hasConcept C2779013556 @default.
• W2179129168 hasConcept C2780283643 @default.
• W2179129168 hasConcept C2780427987 @default.
• W2179129168 hasConcept C2781187634 @default.
• W2179129168 hasConcept C29906990 @default.
• W2179129168 hasConcept C3019054536 @default.
• W2179129168 hasConcept C501734568 @default.

• next