FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179216232> ?p ?o ?g. }

• W2179216232 endingPage "14875" @default.
• W2179216232 startingPage "14870" @default.
• W2179216232 abstract "The vertebrate photoreceptor cell contains an elaborate cilium that includes a stack of phototransductive membrane disks. The disk membranes are continually renewed, but how new disks are formed remains poorly understood. Here we used electron microscope tomography to obtain 3D visualization of the nascent disks of rod photoreceptors in three mammalian species, to gain insight into the process of disk morphogenesis. We observed that nascent disks are invariably continuous with the ciliary plasma membrane, although, owing to partial enclosure, they can appear to be internal in 2D profiles. Tomographic analyses of the basal-most region of the outer segment show changes in shape of the ciliary plasma membrane indicating an invagination, which is likely a first step in disk formation. The invagination flattens to create the proximal surface of an evaginating lamella, as well as membrane protrusions that extend between adjacent lamellae, thereby initiating a disk rim. Immediately distal to this initiation site, lamellae of increasing diameter are evident, indicating growth outward from the cilium. In agreement with a previous model, our data indicate that mature disks are formed once lamellae reach full diameter, and the growth of a rim encloses the space between adjacent surfaces of two lamellae. This study provides 3D data of nascent and mature rod photoreceptor disk membranes at unprecedented z-axis depth and resolution, and provides a basis for addressing fundamental questions, ranging from protein sorting in the photoreceptor cilium to photoreceptor electrophysiology." @default.
• W2179216232 created "2016-06-24" @default.
• W2179216232 creator A5001171242 @default.
• W2179216232 creator A5012163808 @default.
• W2179216232 creator A5018058801 @default.
• W2179216232 creator A5024076723 @default.
• W2179216232 creator A5030244882 @default.
• W2179216232 creator A5041046118 @default.
• W2179216232 creator A5042030924 @default.
• W2179216232 creator A5042160837 @default.
• W2179216232 creator A5077453291 @default.
• W2179216232 date "2015-11-17" @default.
• W2179216232 modified "2023-10-18" @default.
• W2179216232 title "Three-dimensional organization of nascent rod outer segment disk membranes" @default.
• W2179216232 cites W107446690 @default.
• W2179216232 cites W1562706122 @default.
• W2179216232 cites W1965667673 @default.
• W2179216232 cites W1966568798 @default.
• W2179216232 cites W1973379981 @default.
• W2179216232 cites W1974781876 @default.
• W2179216232 cites W1978810668 @default.
• W2179216232 cites W1985163705 @default.
• W2179216232 cites W1992858114 @default.
• W2179216232 cites W1993805514 @default.
• W2179216232 cites W1994048440 @default.
• W2179216232 cites W2000205353 @default.
• W2179216232 cites W2007127198 @default.
• W2179216232 cites W2009432227 @default.
• W2179216232 cites W2013322636 @default.
• W2179216232 cites W2021796370 @default.
• W2179216232 cites W2031051308 @default.
• W2179216232 cites W2034070714 @default.
• W2179216232 cites W2039010865 @default.
• W2179216232 cites W2043597653 @default.
• W2179216232 cites W2053982911 @default.
• W2179216232 cites W2066780072 @default.
• W2179216232 cites W2068918824 @default.
• W2179216232 cites W2075365540 @default.
• W2179216232 cites W2075844449 @default.
• W2179216232 cites W2086790354 @default.
• W2179216232 cites W2089559975 @default.
• W2179216232 cites W2089976967 @default.
• W2179216232 cites W2110829301 @default.
• W2179216232 cites W2119374840 @default.
• W2179216232 cites W2134996138 @default.
• W2179216232 cites W2135816885 @default.
• W2179216232 cites W2138014302 @default.
• W2179216232 cites W2150218224 @default.
• W2179216232 cites W2162478996 @default.
• W2179216232 cites W2166676034 @default.
• W2179216232 cites W94952055 @default.
• W2179216232 cites W986680 @default.
• W2179216232 doi "https://doi.org/10.1073/pnas.1516309112" @default.
• W2179216232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4672767" @default.
• W2179216232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26578801" @default.
• W2179216232 hasPublicationYear "2015" @default.
• W2179216232 type Work @default.
• W2179216232 sameAs 2179216232 @default.
• W2179216232 citedByCount "66" @default.
• W2179216232 countsByYear W21792162322015 @default.
• W2179216232 countsByYear W21792162322016 @default.
• W2179216232 countsByYear W21792162322017 @default.
• W2179216232 countsByYear W21792162322018 @default.
• W2179216232 countsByYear W21792162322019 @default.
• W2179216232 countsByYear W21792162322020 @default.
• W2179216232 countsByYear W21792162322021 @default.
• W2179216232 countsByYear W21792162322022 @default.
• W2179216232 countsByYear W21792162322023 @default.
• W2179216232 crossrefType "journal-article" @default.
• W2179216232 hasAuthorship W2179216232A5001171242 @default.
• W2179216232 hasAuthorship W2179216232A5012163808 @default.
• W2179216232 hasAuthorship W2179216232A5018058801 @default.
• W2179216232 hasAuthorship W2179216232A5024076723 @default.
• W2179216232 hasAuthorship W2179216232A5030244882 @default.
• W2179216232 hasAuthorship W2179216232A5041046118 @default.
• W2179216232 hasAuthorship W2179216232A5042030924 @default.
• W2179216232 hasAuthorship W2179216232A5042160837 @default.
• W2179216232 hasAuthorship W2179216232A5077453291 @default.
• W2179216232 hasBestOaLocation W21792162321 @default.
• W2179216232 hasConcept C100094513 @default.
• W2179216232 hasConcept C104317684 @default.
• W2179216232 hasConcept C105702510 @default.
• W2179216232 hasConcept C115811362 @default.
• W2179216232 hasConcept C12554922 @default.
• W2179216232 hasConcept C131151476 @default.
• W2179216232 hasConcept C136301237 @default.
• W2179216232 hasConcept C40692019 @default.
• W2179216232 hasConcept C41625074 @default.
• W2179216232 hasConcept C54355233 @default.
• W2179216232 hasConcept C55493867 @default.
• W2179216232 hasConcept C86803240 @default.
• W2179216232 hasConcept C95444343 @default.
• W2179216232 hasConceptScore W2179216232C100094513 @default.
• W2179216232 hasConceptScore W2179216232C104317684 @default.
• W2179216232 hasConceptScore W2179216232C105702510 @default.
• W2179216232 hasConceptScore W2179216232C115811362 @default.
• W2179216232 hasConceptScore W2179216232C12554922 @default.
• W2179216232 hasConceptScore W2179216232C131151476 @default.

• next