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- W2179428058 abstract "We present a method for reducing the risk of decompression sickness (DCS) in rats exposed to high pressures of H 2 . Suspensions of the human colonic microbe Methanobrevibacter smithii were introduced via a colonic cannula into the large intestines of the rats. While the rats breathed H 2 in a hyperbaric chamber, the microbe metabolized some of the H 2 diffusing into the intestine, converting H 2 and CO 2 to methane and water. Rate of release of methane from the rats, which was monitored by gas chromatography, varied with chamber H 2 pressure. This rate was higher during decompression than during compression, suggesting that during decompression the microbe was metabolizing H 2 stored in the rats’ tissues. Rats treated with M. smithii had a 25% (5 of 20) incidence of DCS, which was significantly lower ( P < 0.01) than the 56% (28 of 50) incidence of untreated controls, brought on by a standardized compression and decompression sequence. Thus using a microbe in the intestine to remove an estimated 5% of the body burden of H 2 reduced DCS risk by more than one-half. This method of biochemical decompression may potentially facilitate human diving." @default.
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- W2179428058 date "1998-09-01" @default.
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- W2179428058 title "Decompression sickness risk in rats by microbial removal of dissolved gas" @default.
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- W2179428058 doi "https://doi.org/10.1152/ajpregu.1998.275.3.r677" @default.
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