Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179456596> ?p ?o ?g. }
- W2179456596 endingPage "81" @default.
- W2179456596 startingPage "73" @default.
- W2179456596 abstract "The present study aimed to evaluate a new Leishmania-specific hypothetical protein, LiHyT, as a vaccine candidate against VL. The immunogenicity of the recombinant protein (rLiHyT) plus saponin was evaluated in BALB/c mice. In the results, it is shown that rLiHyT plus saponin vaccinated mice produced high levels of IFN-γ, IL-12, and GM-CSF after in vitro stimulation of spleen cells using both rLiHyT and Leishmania infantum SLA. The protective efficacy was evaluated after subcutaneous challenge with stationary promastigotes of L. infantum. Immunized and infected mice, when compared to the controls, showed significant reductions in the number of parasites in the liver, spleen, bone marrow, and in the paws' draining lymph nodes. Protection was associated with an IL-12-dependent production of IFN-γ, mainly by CD4(+) T cells, with a minor contribution of CD8(+) T cells. In these mice, a decrease in the parasite-mediated IL-4 and IL-10 responses, as well as a predominance of LiHyT- and parasite-specific IgG2a isotype antibodies, were also observed. The present study showed that a new Leishmania-specific protein, when combined with a Th1-type adjuvant, presents potential to be used as a vaccine against VL." @default.
- W2179456596 created "2016-06-24" @default.
- W2179456596 creator A5003708797 @default.
- W2179456596 creator A5005734295 @default.
- W2179456596 creator A5007805021 @default.
- W2179456596 creator A5029362872 @default.
- W2179456596 creator A5032394490 @default.
- W2179456596 creator A5037363770 @default.
- W2179456596 creator A5062945956 @default.
- W2179456596 creator A5067888096 @default.
- W2179456596 creator A5070084843 @default.
- W2179456596 creator A5073176841 @default.
- W2179456596 creator A5076724761 @default.
- W2179456596 creator A5080076108 @default.
- W2179456596 date "2016-02-01" @default.
- W2179456596 modified "2023-10-17" @default.
- W2179456596 title "A new Leishmania-specific hypothetical protein, LiHyT, used as a vaccine antigen against visceral leishmaniasis" @default.
- W2179456596 cites W1516532095 @default.
- W2179456596 cites W1578972684 @default.
- W2179456596 cites W1964950347 @default.
- W2179456596 cites W1981620631 @default.
- W2179456596 cites W1986640849 @default.
- W2179456596 cites W1986686460 @default.
- W2179456596 cites W1990802251 @default.
- W2179456596 cites W1995028301 @default.
- W2179456596 cites W2006318766 @default.
- W2179456596 cites W2011196781 @default.
- W2179456596 cites W2022412760 @default.
- W2179456596 cites W2022851527 @default.
- W2179456596 cites W2032947307 @default.
- W2179456596 cites W2038879948 @default.
- W2179456596 cites W2040093002 @default.
- W2179456596 cites W2043254099 @default.
- W2179456596 cites W2053059593 @default.
- W2179456596 cites W2056956379 @default.
- W2179456596 cites W2058411735 @default.
- W2179456596 cites W2062690902 @default.
- W2179456596 cites W2068518858 @default.
- W2179456596 cites W2095345300 @default.
- W2179456596 cites W2104902298 @default.
- W2179456596 cites W2107915297 @default.
- W2179456596 cites W2117451755 @default.
- W2179456596 cites W2126563569 @default.
- W2179456596 cites W2128456068 @default.
- W2179456596 cites W2128488216 @default.
- W2179456596 cites W2131206903 @default.
- W2179456596 cites W2134325500 @default.
- W2179456596 cites W2138562734 @default.
- W2179456596 cites W2141057399 @default.
- W2179456596 cites W2141607191 @default.
- W2179456596 cites W2150414340 @default.
- W2179456596 cites W2168212167 @default.
- W2179456596 cites W2170464746 @default.
- W2179456596 cites W287574767 @default.
- W2179456596 cites W4250756769 @default.
- W2179456596 cites W564613651 @default.
- W2179456596 doi "https://doi.org/10.1016/j.actatropica.2015.11.006" @default.
- W2179456596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26593442" @default.
- W2179456596 hasPublicationYear "2016" @default.
- W2179456596 type Work @default.
- W2179456596 sameAs 2179456596 @default.
- W2179456596 citedByCount "19" @default.
- W2179456596 countsByYear W21794565962016 @default.
- W2179456596 countsByYear W21794565962017 @default.
- W2179456596 countsByYear W21794565962018 @default.
- W2179456596 countsByYear W21794565962019 @default.
- W2179456596 countsByYear W21794565962020 @default.
- W2179456596 countsByYear W21794565962021 @default.
- W2179456596 countsByYear W21794565962022 @default.
- W2179456596 countsByYear W21794565962023 @default.
- W2179456596 crossrefType "journal-article" @default.
- W2179456596 hasAuthorship W2179456596A5003708797 @default.
- W2179456596 hasAuthorship W2179456596A5005734295 @default.
- W2179456596 hasAuthorship W2179456596A5007805021 @default.
- W2179456596 hasAuthorship W2179456596A5029362872 @default.
- W2179456596 hasAuthorship W2179456596A5032394490 @default.
- W2179456596 hasAuthorship W2179456596A5037363770 @default.
- W2179456596 hasAuthorship W2179456596A5062945956 @default.
- W2179456596 hasAuthorship W2179456596A5067888096 @default.
- W2179456596 hasAuthorship W2179456596A5070084843 @default.
- W2179456596 hasAuthorship W2179456596A5073176841 @default.
- W2179456596 hasAuthorship W2179456596A5076724761 @default.
- W2179456596 hasAuthorship W2179456596A5080076108 @default.
- W2179456596 hasConcept C136764020 @default.
- W2179456596 hasConcept C147483822 @default.
- W2179456596 hasConcept C159047783 @default.
- W2179456596 hasConcept C159654299 @default.
- W2179456596 hasConcept C167672396 @default.
- W2179456596 hasConcept C203014093 @default.
- W2179456596 hasConcept C2776555147 @default.
- W2179456596 hasConcept C2777863537 @default.
- W2179456596 hasConcept C2778689377 @default.
- W2179456596 hasConcept C2779053233 @default.
- W2179456596 hasConcept C2780599195 @default.
- W2179456596 hasConcept C2780868878 @default.
- W2179456596 hasConcept C2780931953 @default.
- W2179456596 hasConcept C2781092759 @default.
- W2179456596 hasConcept C2781257258 @default.