FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179460779> ?p ?o ?g. }

• W2179460779 endingPage "338" @default.
• W2179460779 startingPage "333" @default.
• W2179460779 abstract "Fluoroquinolones (FQs) are important in the treatment of MDR-TB and in the definition of XDR-TB. Our objective was to investigate how discrepancies in the phenotypic and genotypic methods for antimicrobial susceptibility testing could affect the interpretation of antimicrobial susceptibility test results.We analysed MICs of ofloxacin and levofloxacin in Middlebrook 7H10 broth (7H10) as well as sequencing of the quinolone resistance-determining region of the gyrA gene and the MTBDRsl assay in 75 resistant isolates, including MDR and XDR strains of Mycobacterium tuberculosis.Among 75 resistant isolates, 27 had mutations associated with FQ resistance. Among isolates with resistance mutations in gyrA, 26% (seven of 27) were susceptible to levofloxacin and ofloxacin by phenotypic testing at 1 mg/L and 2 mg/L. The most common mutation was in codon 94 and these isolates had significantly increased MICs of levofloxacin (2-8 mg/L) compared with isolates with mutations in codon 90 (0.25-2 mg/L, P < 0.05). The sensitivity and specificity for the MTBDRsl assay compared with gyrA sequencing were 96% and 98%, respectively.Current critical concentrations may classify up to 26% of isolates with gyrA mutations as susceptible to FQs due to a close relationship between susceptible and resistant populations. These results should be considered while improving clinical breakpoints for M. tuberculosis and may have an impact on the definition of XDR-TB." @default.
• W2179460779 created "2016-06-24" @default.
• W2179460779 creator A5004848467 @default.
• W2179460779 creator A5012120915 @default.
• W2179460779 creator A5015642749 @default.
• W2179460779 creator A5024502790 @default.
• W2179460779 creator A5024736923 @default.
• W2179460779 creator A5030569559 @default.
• W2179460779 creator A5037967289 @default.
• W2179460779 creator A5041660736 @default.
• W2179460779 creator A5079871021 @default.
• W2179460779 date "2015-11-03" @default.
• W2179460779 modified "2023-10-12" @default.
• W2179460779 title "Susceptibility testing breakpoints for<i>Mycobacterium tuberculosis</i>categorize isolates with resistance mutations in<i>gyrA</i>as susceptible to fluoroquinolones: implications for MDR-TB treatment and the definition of XDR-TB" @default.
• W2179460779 cites W1821013229 @default.
• W2179460779 cites W1977335789 @default.
• W2179460779 cites W2008858822 @default.
• W2179460779 cites W2012383885 @default.
• W2179460779 cites W2014274983 @default.
• W2179460779 cites W2025813566 @default.
• W2179460779 cites W2027951201 @default.
• W2179460779 cites W2062095762 @default.
• W2179460779 cites W2100197432 @default.
• W2179460779 cites W2106163016 @default.
• W2179460779 cites W2124584779 @default.
• W2179460779 cites W2128057974 @default.
• W2179460779 cites W2133481564 @default.
• W2179460779 cites W2140862820 @default.
• W2179460779 cites W2140993748 @default.
• W2179460779 cites W2142944749 @default.
• W2179460779 cites W2145441337 @default.
• W2179460779 cites W2152513822 @default.
• W2179460779 cites W2168509294 @default.
• W2179460779 cites W2172065562 @default.
• W2179460779 doi "https://doi.org/10.1093/jac/dkv353" @default.
• W2179460779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26538509" @default.
• W2179460779 hasPublicationYear "2015" @default.
• W2179460779 type Work @default.
• W2179460779 sameAs 2179460779 @default.
• W2179460779 citedByCount "12" @default.
• W2179460779 countsByYear W21794607792016 @default.
• W2179460779 countsByYear W21794607792017 @default.
• W2179460779 countsByYear W21794607792018 @default.
• W2179460779 countsByYear W21794607792020 @default.
• W2179460779 countsByYear W21794607792021 @default.
• W2179460779 countsByYear W21794607792022 @default.
• W2179460779 countsByYear W21794607792023 @default.
• W2179460779 crossrefType "journal-article" @default.
• W2179460779 hasAuthorship W2179460779A5004848467 @default.
• W2179460779 hasAuthorship W2179460779A5012120915 @default.
• W2179460779 hasAuthorship W2179460779A5015642749 @default.
• W2179460779 hasAuthorship W2179460779A5024502790 @default.
• W2179460779 hasAuthorship W2179460779A5024736923 @default.
• W2179460779 hasAuthorship W2179460779A5030569559 @default.
• W2179460779 hasAuthorship W2179460779A5037967289 @default.
• W2179460779 hasAuthorship W2179460779A5041660736 @default.
• W2179460779 hasAuthorship W2179460779A5079871021 @default.
• W2179460779 hasBestOaLocation W21794607791 @default.
• W2179460779 hasConcept C104317684 @default.
• W2179460779 hasConcept C135763542 @default.
• W2179460779 hasConcept C142724271 @default.
• W2179460779 hasConcept C159047783 @default.
• W2179460779 hasConcept C167125095 @default.
• W2179460779 hasConcept C176947019 @default.
• W2179460779 hasConcept C2777975735 @default.
• W2179460779 hasConcept C2778049240 @default.
• W2179460779 hasConcept C2778512257 @default.
• W2179460779 hasConcept C2781069245 @default.
• W2179460779 hasConcept C2781276175 @default.
• W2179460779 hasConcept C3019249092 @default.
• W2179460779 hasConcept C501593827 @default.
• W2179460779 hasConcept C54355233 @default.
• W2179460779 hasConcept C547475151 @default.
• W2179460779 hasConcept C71924100 @default.
• W2179460779 hasConcept C86803240 @default.
• W2179460779 hasConcept C89423630 @default.
• W2179460779 hasConceptScore W2179460779C104317684 @default.
• W2179460779 hasConceptScore W2179460779C135763542 @default.
• W2179460779 hasConceptScore W2179460779C142724271 @default.
• W2179460779 hasConceptScore W2179460779C159047783 @default.
• W2179460779 hasConceptScore W2179460779C167125095 @default.
• W2179460779 hasConceptScore W2179460779C176947019 @default.
• W2179460779 hasConceptScore W2179460779C2777975735 @default.
• W2179460779 hasConceptScore W2179460779C2778049240 @default.
• W2179460779 hasConceptScore W2179460779C2778512257 @default.
• W2179460779 hasConceptScore W2179460779C2781069245 @default.
• W2179460779 hasConceptScore W2179460779C2781276175 @default.
• W2179460779 hasConceptScore W2179460779C3019249092 @default.
• W2179460779 hasConceptScore W2179460779C501593827 @default.
• W2179460779 hasConceptScore W2179460779C54355233 @default.
• W2179460779 hasConceptScore W2179460779C547475151 @default.
• W2179460779 hasConceptScore W2179460779C71924100 @default.
• W2179460779 hasConceptScore W2179460779C86803240 @default.
• W2179460779 hasConceptScore W2179460779C89423630 @default.
• W2179460779 hasFunder F4320324308 @default.
• W2179460779 hasFunder F4320327344 @default.
• W2179460779 hasIssue "2" @default.
• W2179460779 hasLocation W21794607791 @default.

• next