Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179518352> ?p ?o ?g. }
- W2179518352 abstract "Toll-like receptor 4 (TLR4) is required for activation of innate immunity upon recognition of lipopolysaccharide (LPS) of Gram-negative bacteria. The ability of TLR4 to respond to a particular LPS species is important since insufficient activation may not prevent bacterial growth while excessive immune reaction may lead to immunopathology associated with sepsis. Here, we investigated the biological activity of LPS from Burkholderia mallei that causes glanders, and from the two well-known opportunistic pathogens Acinetobacter baumannii and Pseudomonas aeruginosa (causative agents of nosocomial infections). For each bacterial strain, R-form LPS preparations were purified by hydrophobic chromatography and the chemical structure of lipid A, an LPS structural component, was elucidated by HR-MALDI-TOF mass spectrometry. The biological activity of LPS samples was evaluated by their ability to induce production of proinflammatory cytokines, such as IL-6 and TNF, by bone marrow-derived macrophages. Our results demonstrate direct correlation between the biological activity of LPS from these pathogenic bacteria and the extent of their lipid A acylation." @default.
- W2179518352 created "2016-06-24" @default.
- W2179518352 creator A5013001925 @default.
- W2179518352 creator A5014818304 @default.
- W2179518352 creator A5029795784 @default.
- W2179518352 creator A5044881711 @default.
- W2179518352 creator A5044907777 @default.
- W2179518352 creator A5047578698 @default.
- W2179518352 creator A5047653193 @default.
- W2179518352 creator A5050829716 @default.
- W2179518352 creator A5054205646 @default.
- W2179518352 creator A5055219188 @default.
- W2179518352 creator A5058435508 @default.
- W2179518352 creator A5060840364 @default.
- W2179518352 creator A5066322039 @default.
- W2179518352 creator A5069447810 @default.
- W2179518352 creator A5079420851 @default.
- W2179518352 creator A5090611366 @default.
- W2179518352 date "2015-11-23" @default.
- W2179518352 modified "2023-10-12" @default.
- W2179518352 title "Structural Relationship of the Lipid A Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei, Acinetobacter baumannii, and Pseudomonas aeruginosa" @default.
- W2179518352 cites W1483162601 @default.
- W2179518352 cites W1525535408 @default.
- W2179518352 cites W1567371750 @default.
- W2179518352 cites W1586717843 @default.
- W2179518352 cites W1743939834 @default.
- W2179518352 cites W1785819724 @default.
- W2179518352 cites W1917578416 @default.
- W2179518352 cites W1928733806 @default.
- W2179518352 cites W1932021609 @default.
- W2179518352 cites W1964331410 @default.
- W2179518352 cites W1967340279 @default.
- W2179518352 cites W1979561657 @default.
- W2179518352 cites W1989834253 @default.
- W2179518352 cites W1993513102 @default.
- W2179518352 cites W1995270130 @default.
- W2179518352 cites W2003768186 @default.
- W2179518352 cites W2004465286 @default.
- W2179518352 cites W2011683499 @default.
- W2179518352 cites W2019737761 @default.
- W2179518352 cites W2020868637 @default.
- W2179518352 cites W2026217419 @default.
- W2179518352 cites W2047128135 @default.
- W2179518352 cites W2057792332 @default.
- W2179518352 cites W2060254451 @default.
- W2179518352 cites W2062835892 @default.
- W2179518352 cites W2065294096 @default.
- W2179518352 cites W2066582344 @default.
- W2179518352 cites W2074037713 @default.
- W2179518352 cites W2086666923 @default.
- W2179518352 cites W2088808467 @default.
- W2179518352 cites W2095833996 @default.
- W2179518352 cites W2102149356 @default.
- W2179518352 cites W2102944206 @default.
- W2179518352 cites W2115850341 @default.
- W2179518352 cites W2127934565 @default.
- W2179518352 cites W2129319296 @default.
- W2179518352 cites W2133449490 @default.
- W2179518352 cites W2151174719 @default.
- W2179518352 cites W2151958462 @default.
- W2179518352 cites W2153135493 @default.
- W2179518352 cites W2159435953 @default.
- W2179518352 cites W2160629650 @default.
- W2179518352 cites W2170836818 @default.
- W2179518352 cites W2170897353 @default.
- W2179518352 cites W2170937769 @default.
- W2179518352 cites W2177193197 @default.
- W2179518352 cites W2228040066 @default.
- W2179518352 cites W2955652692 @default.
- W2179518352 cites W97153398 @default.
- W2179518352 doi "https://doi.org/10.3389/fimmu.2015.00595" @default.
- W2179518352 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4655328" @default.
- W2179518352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26635809" @default.
- W2179518352 hasPublicationYear "2015" @default.
- W2179518352 type Work @default.
- W2179518352 sameAs 2179518352 @default.
- W2179518352 citedByCount "33" @default.
- W2179518352 countsByYear W21795183522016 @default.
- W2179518352 countsByYear W21795183522017 @default.
- W2179518352 countsByYear W21795183522018 @default.
- W2179518352 countsByYear W21795183522019 @default.
- W2179518352 countsByYear W21795183522020 @default.
- W2179518352 countsByYear W21795183522021 @default.
- W2179518352 countsByYear W21795183522022 @default.
- W2179518352 countsByYear W21795183522023 @default.
- W2179518352 crossrefType "journal-article" @default.
- W2179518352 hasAuthorship W2179518352A5013001925 @default.
- W2179518352 hasAuthorship W2179518352A5014818304 @default.
- W2179518352 hasAuthorship W2179518352A5029795784 @default.
- W2179518352 hasAuthorship W2179518352A5044881711 @default.
- W2179518352 hasAuthorship W2179518352A5044907777 @default.
- W2179518352 hasAuthorship W2179518352A5047578698 @default.
- W2179518352 hasAuthorship W2179518352A5047653193 @default.
- W2179518352 hasAuthorship W2179518352A5050829716 @default.
- W2179518352 hasAuthorship W2179518352A5054205646 @default.
- W2179518352 hasAuthorship W2179518352A5055219188 @default.
- W2179518352 hasAuthorship W2179518352A5058435508 @default.
- W2179518352 hasAuthorship W2179518352A5060840364 @default.
- W2179518352 hasAuthorship W2179518352A5066322039 @default.
- W2179518352 hasAuthorship W2179518352A5069447810 @default.