FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179518384> ?p ?o ?g. }

• W2179518384 endingPage "60" @default.
• W2179518384 startingPage "51" @default.
• W2179518384 abstract "There are two subtypes of orexin receptors, OX1 and OX2. Signalling pathways have been mapped in much higher detail for OX1 receptors than OX2 receptors. Almost all the detailed studies have been performed in Chinese hamster ovary cells, and we thus chose the same cell background for the studies on human OX2 receptors to allow comparison to human OX1 receptors. Adenylyl cyclase, phospholipase A2, C and D and diacylglycerol lipase activities were assessed by precursor radiolabelling and chromatographic separation (ion exchange, affinity or thin layer), calcium by a fluorescent method, and receptor binding with [(125)I]-orexin-A. Upon activation with orexin-A, OX2 receptors stimulated phospholipase A2, C and D, diacylglycerol lipase and calcium elevation, and both inhibited and stimulated adenylyl cyclase; i.e., the responses to OX2 activation by orexin-A were principally like those of OX1, in contrast to some previous suggestions. The responses occurred mostly in the same concentration range as those for OX1 activation and via the same signal cascades. However, some responses were weaker, suggesting a partially differential coupling to some cascades. In summary, OX2 receptor signalling is principally similar to OX1 receptor signalling suggesting also a physiologically similar coupling, though this needs to be verified in physiological contexts. Some (relatively weak) differences between the receptors may be investigated in further studies." @default.
• W2179518384 created "2016-06-24" @default.
• W2179518384 creator A5080765918 @default.
• W2179518384 date "2016-02-01" @default.
• W2179518384 modified "2023-10-16" @default.
• W2179518384 title "OX2 orexin/hypocretin receptor signal transduction in recombinant Chinese hamster ovary cells" @default.
• W2179518384 cites W1490311409 @default.
• W2179518384 cites W1501722970 @default.
• W2179518384 cites W1671441783 @default.
• W2179518384 cites W1918384039 @default.
• W2179518384 cites W1967866139 @default.
• W2179518384 cites W1968685537 @default.
• W2179518384 cites W1969581325 @default.
• W2179518384 cites W1977998991 @default.
• W2179518384 cites W1982487448 @default.
• W2179518384 cites W1984311579 @default.
• W2179518384 cites W1985579250 @default.
• W2179518384 cites W1986447940 @default.
• W2179518384 cites W2001652592 @default.
• W2179518384 cites W2017384587 @default.
• W2179518384 cites W2022180074 @default.
• W2179518384 cites W2026795663 @default.
• W2179518384 cites W2027721701 @default.
• W2179518384 cites W2027740042 @default.
• W2179518384 cites W2031872434 @default.
• W2179518384 cites W2033547042 @default.
• W2179518384 cites W2036325467 @default.
• W2179518384 cites W2051726070 @default.
• W2179518384 cites W2061617773 @default.
• W2179518384 cites W2064897077 @default.
• W2179518384 cites W2065389311 @default.
• W2179518384 cites W2066600235 @default.
• W2179518384 cites W2067025602 @default.
• W2179518384 cites W2069066834 @default.
• W2179518384 cites W2075744025 @default.
• W2179518384 cites W2077755739 @default.
• W2179518384 cites W2081304615 @default.
• W2179518384 cites W2082915641 @default.
• W2179518384 cites W2098228975 @default.
• W2179518384 cites W2133533221 @default.
• W2179518384 cites W2138325877 @default.
• W2179518384 cites W2154737090 @default.
• W2179518384 cites W2157584035 @default.
• W2179518384 cites W2158990709 @default.
• W2179518384 cites W2162670271 @default.
• W2179518384 cites W2164675383 @default.
• W2179518384 cites W2166672372 @default.
• W2179518384 cites W2166806732 @default.
• W2179518384 doi "https://doi.org/10.1016/j.cellsig.2015.11.009" @default.
• W2179518384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26582739" @default.
• W2179518384 hasPublicationYear "2016" @default.
• W2179518384 type Work @default.
• W2179518384 sameAs 2179518384 @default.
• W2179518384 citedByCount "15" @default.
• W2179518384 countsByYear W21795183842016 @default.
• W2179518384 countsByYear W21795183842017 @default.
• W2179518384 countsByYear W21795183842018 @default.
• W2179518384 countsByYear W21795183842019 @default.
• W2179518384 countsByYear W21795183842021 @default.
• W2179518384 countsByYear W21795183842022 @default.
• W2179518384 countsByYear W21795183842023 @default.
• W2179518384 crossrefType "journal-article" @default.
• W2179518384 hasAuthorship W2179518384A5080765918 @default.
• W2179518384 hasConcept C118303440 @default.
• W2179518384 hasConcept C163235415 @default.
• W2179518384 hasConcept C170493617 @default.
• W2179518384 hasConcept C171089720 @default.
• W2179518384 hasConcept C175656101 @default.
• W2179518384 hasConcept C185592680 @default.
• W2179518384 hasConcept C195794163 @default.
• W2179518384 hasConcept C2776175234 @default.
• W2179518384 hasConcept C2778597717 @default.
• W2179518384 hasConcept C2779178603 @default.
• W2179518384 hasConcept C2779605129 @default.
• W2179518384 hasConcept C2779680196 @default.
• W2179518384 hasConcept C36020004 @default.
• W2179518384 hasConcept C39567582 @default.
• W2179518384 hasConcept C55493867 @default.
• W2179518384 hasConcept C62478195 @default.
• W2179518384 hasConcept C86803240 @default.
• W2179518384 hasConcept C95444343 @default.
• W2179518384 hasConceptScore W2179518384C118303440 @default.
• W2179518384 hasConceptScore W2179518384C163235415 @default.
• W2179518384 hasConceptScore W2179518384C170493617 @default.
• W2179518384 hasConceptScore W2179518384C171089720 @default.
• W2179518384 hasConceptScore W2179518384C175656101 @default.
• W2179518384 hasConceptScore W2179518384C185592680 @default.
• W2179518384 hasConceptScore W2179518384C195794163 @default.
• W2179518384 hasConceptScore W2179518384C2776175234 @default.
• W2179518384 hasConceptScore W2179518384C2778597717 @default.
• W2179518384 hasConceptScore W2179518384C2779178603 @default.
• W2179518384 hasConceptScore W2179518384C2779605129 @default.
• W2179518384 hasConceptScore W2179518384C2779680196 @default.
• W2179518384 hasConceptScore W2179518384C36020004 @default.
• W2179518384 hasConceptScore W2179518384C39567582 @default.
• W2179518384 hasConceptScore W2179518384C55493867 @default.
• W2179518384 hasConceptScore W2179518384C62478195 @default.
• W2179518384 hasConceptScore W2179518384C86803240 @default.

• next