Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179545817> ?p ?o ?g. }
- W2179545817 endingPage "425" @default.
- W2179545817 startingPage "417" @default.
- W2179545817 abstract "A high percentage of regulatory T cells (Tregs) among tumor-infiltrating lymphocytes weakens the immune response against tumors. The anergy of effector T cells (Teff) can be reversed by immune checkpoint treatment, which inhibits Tregs and boosts the activation of Teff. Both effects can be obtained by triggering the glucocorticoid-induced TNF receptor-related (GITR), a costimulatory molecule expressed by Teff and Tregs, and by inhibiting the programmed cell death (PD)-1 receptor, an inhibitory molecule expressed by Teff. Patent W02015026684A1 provides a method of treating human tumors using a combination of a molecule triggering GITR and another inhibiting PD-1. The treatment approach was tested on three murine models of cancer, and the synergic effect of antihuman antibodies (Abs) in combination was tested in mixed lymphocyte reactions. Immune checkpoint treatment can break tolerance toward tumors and promote tumor rejection. The patented approach is very interesting and might be successful. The combined use of PD-1 antagonists and GITR agonists is synergic and tumor-centered, and adverse events might be less problematic than expected. A crucial point in translating the murine studies to humans is the differences between murine and human GITR and the evidence that some antihuman GITR Abs are not agonists." @default.
- W2179545817 created "2016-06-24" @default.
- W2179545817 creator A5005917970 @default.
- W2179545817 creator A5048626133 @default.
- W2179545817 creator A5070881182 @default.
- W2179545817 creator A5073526459 @default.
- W2179545817 date "2016-02-15" @default.
- W2179545817 modified "2023-09-23" @default.
- W2179545817 title "Modulation of tumor immunity: a patent evaluation of WO2015026684A1" @default.
- W2179545817 cites W1202139631 @default.
- W2179545817 cites W1499227624 @default.
- W2179545817 cites W1517049862 @default.
- W2179545817 cites W1538902372 @default.
- W2179545817 cites W1540891930 @default.
- W2179545817 cites W1568519368 @default.
- W2179545817 cites W1602071727 @default.
- W2179545817 cites W1766682057 @default.
- W2179545817 cites W1869037406 @default.
- W2179545817 cites W1893566975 @default.
- W2179545817 cites W1968060525 @default.
- W2179545817 cites W1972114621 @default.
- W2179545817 cites W1972999648 @default.
- W2179545817 cites W1973991237 @default.
- W2179545817 cites W1982488143 @default.
- W2179545817 cites W1982875501 @default.
- W2179545817 cites W1984484036 @default.
- W2179545817 cites W1985735048 @default.
- W2179545817 cites W1987165863 @default.
- W2179545817 cites W1987802826 @default.
- W2179545817 cites W1989565558 @default.
- W2179545817 cites W1990675339 @default.
- W2179545817 cites W1990723041 @default.
- W2179545817 cites W1993546867 @default.
- W2179545817 cites W1999227421 @default.
- W2179545817 cites W1999245418 @default.
- W2179545817 cites W2001502818 @default.
- W2179545817 cites W2004409905 @default.
- W2179545817 cites W2007089361 @default.
- W2179545817 cites W2007868209 @default.
- W2179545817 cites W2014615053 @default.
- W2179545817 cites W2018388708 @default.
- W2179545817 cites W2026426963 @default.
- W2179545817 cites W2027355728 @default.
- W2179545817 cites W2033746426 @default.
- W2179545817 cites W2044463356 @default.
- W2179545817 cites W2045775897 @default.
- W2179545817 cites W2049984546 @default.
- W2179545817 cites W2060070314 @default.
- W2179545817 cites W2063264144 @default.
- W2179545817 cites W2066582914 @default.
- W2179545817 cites W2077143212 @default.
- W2179545817 cites W2095032808 @default.
- W2179545817 cites W2095699174 @default.
- W2179545817 cites W2099314444 @default.
- W2179545817 cites W2101449057 @default.
- W2179545817 cites W2101653483 @default.
- W2179545817 cites W2104072610 @default.
- W2179545817 cites W2104742976 @default.
- W2179545817 cites W2105459360 @default.
- W2179545817 cites W2106511557 @default.
- W2179545817 cites W2106511606 @default.
- W2179545817 cites W2107484016 @default.
- W2179545817 cites W2111346510 @default.
- W2179545817 cites W2112121482 @default.
- W2179545817 cites W2112123471 @default.
- W2179545817 cites W2118982164 @default.
- W2179545817 cites W2119007548 @default.
- W2179545817 cites W2121626779 @default.
- W2179545817 cites W2128035403 @default.
- W2179545817 cites W2130513535 @default.
- W2179545817 cites W2131778873 @default.
- W2179545817 cites W2132207502 @default.
- W2179545817 cites W2134093322 @default.
- W2179545817 cites W2134435470 @default.
- W2179545817 cites W2138887185 @default.
- W2179545817 cites W2139724384 @default.
- W2179545817 cites W2145066420 @default.
- W2179545817 cites W2145453174 @default.
- W2179545817 cites W2151151763 @default.
- W2179545817 cites W2152897456 @default.
- W2179545817 cites W2154280336 @default.
- W2179545817 cites W2156353875 @default.
- W2179545817 cites W2160834915 @default.
- W2179545817 cites W2166256145 @default.
- W2179545817 cites W2171775390 @default.
- W2179545817 cites W2244578404 @default.
- W2179545817 cites W2318212002 @default.
- W2179545817 cites W2419268404 @default.
- W2179545817 cites W3061157080 @default.
- W2179545817 cites W4205811845 @default.
- W2179545817 cites W4239710358 @default.
- W2179545817 cites W98240345 @default.
- W2179545817 doi "https://doi.org/10.1517/13543776.2016.1118061" @default.
- W2179545817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26560753" @default.
- W2179545817 hasPublicationYear "2016" @default.
- W2179545817 type Work @default.
- W2179545817 sameAs 2179545817 @default.
- W2179545817 citedByCount "8" @default.