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- W2179672927 abstract "Fanconi anemia (FA) is a recessively inherited disease manifesting developmental abnormalities, bone marrow failure, and increased risk of malignancies. Whereas FA has been studied for nearly 90 years, only in the last 20 years have increasing numbers of genes been implicated in the pathogenesis associated with this genetic disease. To date, 19 genes have been identified that encode Fanconi anemia complementation group proteins, all of which are named or aliased, using the root symbol FANC. Fanconi anemia subtype (FANC) proteins function in a common DNA repair pathway called the FA pathway, which is essential for maintaining genomic integrity. The various FANC mutant proteins contribute to distinct steps associated with FA pathogenesis. Herein, we provide a review update of the 19 human FANC and their mouse orthologs, an evolutionary perspective on the FANC genes, and the functional significance of the FA DNA repair pathway in association with clinical disorders. This is an example of a set of genes--known to exist in vertebrates, invertebrates, plants, and yeast--that are grouped together on the basis of shared biochemical and physiological functions, rather than evolutionary phylogeny, and have been named on this basis by the HUGO Gene Nomenclature Committee (HGNC)." @default.
- W2179672927 created "2016-06-24" @default.
- W2179672927 creator A5028440222 @default.
- W2179672927 creator A5029136277 @default.
- W2179672927 creator A5029237881 @default.
- W2179672927 creator A5048187845 @default.
- W2179672927 creator A5069585147 @default.
- W2179672927 creator A5072710254 @default.
- W2179672927 date "2015-11-24" @default.
- W2179672927 modified "2023-10-10" @default.
- W2179672927 title "Update of the human and mouse Fanconi anemia genes" @default.
- W2179672927 cites W1495571943 @default.
- W2179672927 cites W1497406478 @default.
- W2179672927 cites W1507694958 @default.
- W2179672927 cites W1531540594 @default.
- W2179672927 cites W1549100097 @default.
- W2179672927 cites W1571913556 @default.
- W2179672927 cites W1576573501 @default.
- W2179672927 cites W1586303233 @default.
- W2179672927 cites W16620579 @default.
- W2179672927 cites W1890108575 @default.
- W2179672927 cites W1890404985 @default.
- W2179672927 cites W1945075856 @default.
- W2179672927 cites W1969258533 @default.
- W2179672927 cites W1970861835 @default.
- W2179672927 cites W1971646622 @default.
- W2179672927 cites W1975125028 @default.
- W2179672927 cites W1976629892 @default.
- W2179672927 cites W1977916286 @default.
- W2179672927 cites W1982046131 @default.
- W2179672927 cites W1987316571 @default.
- W2179672927 cites W1994677283 @default.
- W2179672927 cites W2001907020 @default.
- W2179672927 cites W2002497339 @default.
- W2179672927 cites W2003058744 @default.
- W2179672927 cites W2007500392 @default.
- W2179672927 cites W2012992309 @default.
- W2179672927 cites W2020983840 @default.
- W2179672927 cites W2022629976 @default.
- W2179672927 cites W2023587106 @default.
- W2179672927 cites W2024332756 @default.
- W2179672927 cites W2031746309 @default.
- W2179672927 cites W2033944364 @default.
- W2179672927 cites W2036295786 @default.
- W2179672927 cites W2038936226 @default.
- W2179672927 cites W2040644533 @default.
- W2179672927 cites W2041205258 @default.
- W2179672927 cites W2043051674 @default.
- W2179672927 cites W2046119833 @default.
- W2179672927 cites W2051087342 @default.
- W2179672927 cites W2054367725 @default.
- W2179672927 cites W2056382644 @default.
- W2179672927 cites W2056946030 @default.
- W2179672927 cites W2059390353 @default.
- W2179672927 cites W2060784304 @default.
- W2179672927 cites W2060871128 @default.
- W2179672927 cites W2062691606 @default.
- W2179672927 cites W2065417936 @default.
- W2179672927 cites W2068655274 @default.
- W2179672927 cites W2073843957 @default.
- W2179672927 cites W2084751512 @default.
- W2179672927 cites W2086742929 @default.
- W2179672927 cites W2087505934 @default.
- W2179672927 cites W2087634145 @default.
- W2179672927 cites W2087967916 @default.
- W2179672927 cites W2094783662 @default.
- W2179672927 cites W2094977104 @default.
- W2179672927 cites W2096402297 @default.
- W2179672927 cites W2098245314 @default.
- W2179672927 cites W2098482403 @default.
- W2179672927 cites W2101161126 @default.
- W2179672927 cites W2106335498 @default.
- W2179672927 cites W2110143309 @default.
- W2179672927 cites W2112146005 @default.
- W2179672927 cites W2112664493 @default.
- W2179672927 cites W2117511932 @default.
- W2179672927 cites W2117816178 @default.
- W2179672927 cites W2118904153 @default.
- W2179672927 cites W2121150109 @default.
- W2179672927 cites W2122441634 @default.
- W2179672927 cites W2123950266 @default.
- W2179672927 cites W2126178372 @default.
- W2179672927 cites W2128700722 @default.
- W2179672927 cites W2128717251 @default.
- W2179672927 cites W2131256286 @default.
- W2179672927 cites W2131915502 @default.
- W2179672927 cites W2132587601 @default.
- W2179672927 cites W2136801799 @default.
- W2179672927 cites W2137273906 @default.
- W2179672927 cites W2139515538 @default.
- W2179672927 cites W2148034261 @default.
- W2179672927 cites W2148389632 @default.
- W2179672927 cites W2154489449 @default.
- W2179672927 cites W2156461272 @default.
- W2179672927 cites W2161998895 @default.
- W2179672927 cites W2163262261 @default.
- W2179672927 cites W2166452682 @default.
- W2179672927 cites W2167844213 @default.
- W2179672927 cites W2252370360 @default.
- W2179672927 cites W4250964040 @default.