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- W2179706064 endingPage "2710" @default.
- W2179706064 startingPage "2697" @default.
- W2179706064 abstract "The present review aimed at discussing the impact, pathogenesis and therapeutic approaches of muscle wasting, which is a major clinical feature of cancer-related cachexia syndrome. The pathogenesis of muscle wasting in cancer cachexia lies in a discrepancy between anabolic and catabolic pathways mediated by chronic inflammation. Effective interventions specifically aimed at hampering muscle loss and enhancing muscle function are still lacking. Promising agents include anti-inflammatory, orexigenic and anabolic drugs, alongside with nutritional supplements that influence the STAT3 and PI3K/Akt/mTOR pathways involved in muscle wasting. Personalized physical activity combined with pharmacological and nutritional support hold promise. A greater understanding of the pathogenetic processes of cancer cachexia-related muscle wasting will enable the development of an early and effective targeted mechanism-based multimodal approach." @default.
- W2179706064 created "2016-06-24" @default.
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- W2179706064 creator A5051507235 @default.
- W2179706064 creator A5060437987 @default.
- W2179706064 creator A5080262303 @default.
- W2179706064 date "2015-10-01" @default.
- W2179706064 modified "2023-10-17" @default.
- W2179706064 title "Muscle wasting as main evidence of energy impairment in cancer cachexia: future therapeutic approaches" @default.
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