Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179775778> ?p ?o ?g. }
- W2179775778 endingPage "4269" @default.
- W2179775778 startingPage "4261" @default.
- W2179775778 abstract "Hedgehog (Hh) signalling from posterior (P) to anterior (A) cells is the primary determinant of AP polarity in the limb field in insects and vertebrates. Hh acts in part by inducing expression of Decapentaplegic (Dpp), but how Hh and Dpp together pattern the central region of the Drosophila wing remains largely unknown. We have re-examined the role played by Collier (Col), a dose-dependent Hh target activated in cells along the AP boundary, the AP organiser in the imaginal wing disc. We found that col mutant wings are smaller than wild type and lack L4 vein, in addition to missing the L3-L4 intervein and mis-positioning of the anterior L3 vein. We link these phenotypes to col requirement for the local upregulation of both emc and N, two genes involved in the control of cell proliferation, the EGFR ligand Vein and the intervein determination gene blistered. We further show that attenuation of Dpp signalling in the AP organiser is also col dependent and, in conjunction with Vein upregulation, required for formation of L4 vein. A model recapitulating the molecular interplay between the Hh, Dpp and EGF signalling pathways in the wing AP organiser is presented." @default.
- W2179775778 created "2016-06-24" @default.
- W2179775778 creator A5000886746 @default.
- W2179775778 creator A5024931520 @default.
- W2179775778 creator A5072984628 @default.
- W2179775778 date "2002-09-15" @default.
- W2179775778 modified "2023-10-17" @default.
- W2179775778 title "Connecting Hh, Dpp and EGF signalling in patterning of the<i>Drosophila</i>wing; the pivotal role of<i>collier/knot</i>in the AP organiser" @default.
- W2179775778 cites W1866472634 @default.
- W2179775778 cites W1909468734 @default.
- W2179775778 cites W1956442739 @default.
- W2179775778 cites W1964929128 @default.
- W2179775778 cites W1966433242 @default.
- W2179775778 cites W1967192173 @default.
- W2179775778 cites W1971753759 @default.
- W2179775778 cites W1979966107 @default.
- W2179775778 cites W1981391168 @default.
- W2179775778 cites W1985095807 @default.
- W2179775778 cites W1991174305 @default.
- W2179775778 cites W1992374635 @default.
- W2179775778 cites W1995968890 @default.
- W2179775778 cites W2000646745 @default.
- W2179775778 cites W2004457343 @default.
- W2179775778 cites W2009455581 @default.
- W2179775778 cites W2022285707 @default.
- W2179775778 cites W2028497134 @default.
- W2179775778 cites W2035595923 @default.
- W2179775778 cites W2038560503 @default.
- W2179775778 cites W2042668510 @default.
- W2179775778 cites W2045105811 @default.
- W2179775778 cites W2049425193 @default.
- W2179775778 cites W2056848917 @default.
- W2179775778 cites W2057723597 @default.
- W2179775778 cites W2072468208 @default.
- W2179775778 cites W2074245751 @default.
- W2179775778 cites W2080213723 @default.
- W2179775778 cites W2085678664 @default.
- W2179775778 cites W2090164447 @default.
- W2179775778 cites W2092252765 @default.
- W2179775778 cites W2092610731 @default.
- W2179775778 cites W2098569028 @default.
- W2179775778 cites W2103886590 @default.
- W2179775778 cites W2105847533 @default.
- W2179775778 cites W2108707301 @default.
- W2179775778 cites W2109638112 @default.
- W2179775778 cites W2112840682 @default.
- W2179775778 cites W2120774732 @default.
- W2179775778 cites W2126122570 @default.
- W2179775778 cites W2136494319 @default.
- W2179775778 cites W2140786734 @default.
- W2179775778 cites W2140932241 @default.
- W2179775778 cites W2158825995 @default.
- W2179775778 cites W2159935247 @default.
- W2179775778 cites W2164205865 @default.
- W2179775778 cites W2166841567 @default.
- W2179775778 cites W2173390200 @default.
- W2179775778 cites W2182792048 @default.
- W2179775778 cites W2183101699 @default.
- W2179775778 cites W2183203573 @default.
- W2179775778 cites W2186234433 @default.
- W2179775778 cites W2186307273 @default.
- W2179775778 cites W2189550019 @default.
- W2179775778 doi "https://doi.org/10.1242/dev.129.18.4261" @default.
- W2179775778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12183378" @default.
- W2179775778 hasPublicationYear "2002" @default.
- W2179775778 type Work @default.
- W2179775778 sameAs 2179775778 @default.
- W2179775778 citedByCount "54" @default.
- W2179775778 countsByYear W21797757782012 @default.
- W2179775778 countsByYear W21797757782013 @default.
- W2179775778 countsByYear W21797757782014 @default.
- W2179775778 countsByYear W21797757782016 @default.
- W2179775778 countsByYear W21797757782017 @default.
- W2179775778 countsByYear W21797757782018 @default.
- W2179775778 countsByYear W21797757782019 @default.
- W2179775778 countsByYear W21797757782020 @default.
- W2179775778 countsByYear W21797757782023 @default.
- W2179775778 crossrefType "journal-article" @default.
- W2179775778 hasAuthorship W2179775778A5000886746 @default.
- W2179775778 hasAuthorship W2179775778A5024931520 @default.
- W2179775778 hasAuthorship W2179775778A5072984628 @default.
- W2179775778 hasConcept C104317684 @default.
- W2179775778 hasConcept C105702510 @default.
- W2179775778 hasConcept C127413603 @default.
- W2179775778 hasConcept C127561419 @default.
- W2179775778 hasConcept C127716648 @default.
- W2179775778 hasConcept C146978453 @default.
- W2179775778 hasConcept C161879069 @default.
- W2179775778 hasConcept C2776735322 @default.
- W2179775778 hasConcept C2777994357 @default.
- W2179775778 hasConcept C2778539099 @default.
- W2179775778 hasConcept C54355233 @default.
- W2179775778 hasConcept C62478195 @default.
- W2179775778 hasConcept C86803240 @default.
- W2179775778 hasConcept C88498014 @default.
- W2179775778 hasConcept C91986751 @default.
- W2179775778 hasConcept C95444343 @default.
- W2179775778 hasConcept C97257150 @default.