FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179894672> ?p ?o ?g. }

• W2179894672 endingPage "202" @default.
• W2179894672 startingPage "193" @default.
• W2179894672 abstract "A deeper understanding of periodontitis pathophysiology is central to future development of novel biomarkers and therapeutics. The following is reported here: 1) an in silico network model of interactions among cell adhesion molecules and a network-focused microarray analysis of the corresponding genes in periodontitis; 2) analysis of secretions of adhesion molecules in gingival tissue samples from patients with periodontitis and healthy controls; and 3) effect of the human neutrophilic peptide-1 (HNP-1) on epithelial adhesion molecules.The network model identified 85 nodes in relation to the interactions of adhesion molecules. Subsequently, the relative gene expression was overlaid on the network model. Differential gene expression was analyzed, and false discovery rate control was performed for statistical assessment of the microarray data. Both tissue and cell culture samples were immunostained for desmocollin (DSC)2, occludin (OCLN), desmoglein (DSG)1, tight junction protein 2, and gap junction protein α.The differential gene expression analysis revealed that the epithelial adhesion molecules were significantly lower in abundance in individuals with periodontitis than controls. In contrast, the genes for leukocyte adhesion molecules showed a significant upregulation. Immunostainings revealed elevated secretions of both DSG1 and OCLN in periodontitis. An in vitro model suggested reduced DSC2 and OCLN secretions in the presence of HNP-1.Gene expression of gingival adhesion molecules in periodontitis is regulated by leukocyte transmigration, whereas the neutrophilic antimicrobial peptide HNP-1 is noted as a putative regulator of epithelial adhesion molecules. These observations contribute to the key mechanisms by which future biomarkers might be developed for periodontitis." @default.
• W2179894672 created "2016-06-24" @default.
• W2179894672 creator A5000380215 @default.
• W2179894672 creator A5005838473 @default.
• W2179894672 creator A5012423795 @default.
• W2179894672 creator A5014025276 @default.
• W2179894672 creator A5031280615 @default.
• W2179894672 creator A5036906345 @default.
• W2179894672 creator A5039796620 @default.
• W2179894672 creator A5063506303 @default.
• W2179894672 creator A5065172877 @default.
• W2179894672 creator A5069579153 @default.
• W2179894672 date "2016-02-01" @default.
• W2179894672 modified "2023-10-18" @default.
• W2179894672 title "Analyses of Gingival Adhesion Molecules in Periodontitis: Theoretical In Silico, Comparative In Vivo, and Explanatory In Vitro Models" @default.
• W2179894672 cites W1850146802 @default.
• W2179894672 cites W1880624715 @default.
• W2179894672 cites W1965299018 @default.
• W2179894672 cites W1973455669 @default.
• W2179894672 cites W1980059877 @default.
• W2179894672 cites W1983480088 @default.
• W2179894672 cites W1991882485 @default.
• W2179894672 cites W1994488087 @default.
• W2179894672 cites W1994960026 @default.
• W2179894672 cites W2006245117 @default.
• W2179894672 cites W2013094760 @default.
• W2179894672 cites W2019533305 @default.
• W2179894672 cites W2034401865 @default.
• W2179894672 cites W2047657575 @default.
• W2179894672 cites W2057545775 @default.
• W2179894672 cites W2074086397 @default.
• W2179894672 cites W2108051579 @default.
• W2179894672 cites W2109629923 @default.
• W2179894672 cites W2111627817 @default.
• W2179894672 cites W2148295420 @default.
• W2179894672 cites W2148445732 @default.
• W2179894672 cites W2148611562 @default.
• W2179894672 cites W2160697532 @default.
• W2179894672 cites W2165625418 @default.
• W2179894672 cites W2166809896 @default.
• W2179894672 cites W2169851453 @default.
• W2179894672 cites W2171504499 @default.
• W2179894672 cites W2208395147 @default.
• W2179894672 cites W2216606064 @default.
• W2179894672 cites W2324042516 @default.
• W2179894672 cites W4210580032 @default.
• W2179894672 cites W4246482931 @default.
• W2179894672 cites W88293337 @default.
• W2179894672 doi "https://doi.org/10.1902/jop.2015.150361" @default.
• W2179894672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26430925" @default.
• W2179894672 hasPublicationYear "2016" @default.
• W2179894672 type Work @default.
• W2179894672 sameAs 2179894672 @default.
• W2179894672 citedByCount "10" @default.
• W2179894672 countsByYear W21798946722016 @default.
• W2179894672 countsByYear W21798946722017 @default.
• W2179894672 countsByYear W21798946722018 @default.
• W2179894672 countsByYear W21798946722020 @default.
• W2179894672 countsByYear W21798946722021 @default.
• W2179894672 countsByYear W21798946722023 @default.
• W2179894672 crossrefType "journal-article" @default.
• W2179894672 hasAuthorship W2179894672A5000380215 @default.
• W2179894672 hasAuthorship W2179894672A5005838473 @default.
• W2179894672 hasAuthorship W2179894672A5012423795 @default.
• W2179894672 hasAuthorship W2179894672A5014025276 @default.
• W2179894672 hasAuthorship W2179894672A5031280615 @default.
• W2179894672 hasAuthorship W2179894672A5036906345 @default.
• W2179894672 hasAuthorship W2179894672A5039796620 @default.
• W2179894672 hasAuthorship W2179894672A5063506303 @default.
• W2179894672 hasAuthorship W2179894672A5065172877 @default.
• W2179894672 hasAuthorship W2179894672A5069579153 @default.
• W2179894672 hasConcept C104317684 @default.
• W2179894672 hasConcept C1491633281 @default.
• W2179894672 hasConcept C150194340 @default.
• W2179894672 hasConcept C16224149 @default.
• W2179894672 hasConcept C178790620 @default.
• W2179894672 hasConcept C185592680 @default.
• W2179894672 hasConcept C199343813 @default.
• W2179894672 hasConcept C203014093 @default.
• W2179894672 hasConcept C207001950 @default.
• W2179894672 hasConcept C2775905019 @default.
• W2179894672 hasConcept C2780385504 @default.
• W2179894672 hasConcept C54355233 @default.
• W2179894672 hasConcept C71924100 @default.
• W2179894672 hasConcept C8415881 @default.
• W2179894672 hasConcept C84416704 @default.
• W2179894672 hasConcept C85789140 @default.
• W2179894672 hasConcept C86803240 @default.
• W2179894672 hasConcept C95444343 @default.
• W2179894672 hasConceptScore W2179894672C104317684 @default.
• W2179894672 hasConceptScore W2179894672C1491633281 @default.
• W2179894672 hasConceptScore W2179894672C150194340 @default.
• W2179894672 hasConceptScore W2179894672C16224149 @default.
• W2179894672 hasConceptScore W2179894672C178790620 @default.
• W2179894672 hasConceptScore W2179894672C185592680 @default.
• W2179894672 hasConceptScore W2179894672C199343813 @default.
• W2179894672 hasConceptScore W2179894672C203014093 @default.
• W2179894672 hasConceptScore W2179894672C207001950 @default.

• next