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• W2179904286 abstract "Research Article1 January 1991free access Identification of the site of interaction of the dihydropyridine channel blockers nitrendipine and azidopine with the calcium-channel alpha 1 subunit. S. Regulla S. Regulla Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author T. Schneider T. Schneider Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author W. Nastainczyk W. Nastainczyk Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author H. E. Meyer H. E. Meyer Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author F. Hofmann F. Hofmann Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author S. Regulla S. Regulla Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author T. Schneider T. Schneider Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author W. Nastainczyk W. Nastainczyk Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author H. E. Meyer H. E. Meyer Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author F. Hofmann F. Hofmann Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. Search for more papers by this author Author Information S. Regulla1, T. Schneider1, W. Nastainczyk1, H. E. Meyer1 and F. Hofmann1 1Medizinische Biochemie, Medizinische Fakultät, Homburg/Saar, FRG. The EMBO Journal (1991)10:45-49https://doi.org/10.1002/j.1460-2075.1991.tb07919.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The dihydropyridine binding site of the rabbit skeletal muscle calcium channel alpha 1 subunit was identified using tritiated azidopine and nitrendipine as ligands. The purified receptor complex was incubated either with azidopine or nitrenidpine at an alpha 1 subunit to ligand ratio of 1:1. The samples were then irradiated by a 200 W UV lamp. The ligands were only incorporated into the alpha 1 subunit, which was isolated by size exclusion chromatography and digested either by trypsin (azidopine) or endoproteinase Asp-N (nitrendipine). Each digest contained two radioactive peptides, which were isolated and sequenced. The azidopine peptides were identical with amino acids 13–18 (minor peak) and 1428–1437 (major peak) of the primary sequence of the skeletal muscle alpha 1 subunit. The nitrendipine peptides were identical with amino acids 1390–1399 (major peak) and 1410–1420 (minor peak). The sequence from amino acids 1390 to 1437 is identical in the alpha 1 subunits of skeletal, cardiac and smooth muscle and follows directly repeat IVS6. These results indicate that dihydropyridines bind to an area that is located at the putative cytosolic domain of the calcium channel. Previous ArticleNext Article Volume 10Issue 11 January 1991In this issue RelatedDetailsLoading ..." @default.
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• W2179904286 title "Identification of the site of interaction of the dihydropyridine channel blockers nitrendipine and azidopine with the calcium-channel alpha 1 subunit." @default.
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• W2179904286 doi "https://doi.org/10.1002/j.1460-2075.1991.tb07919.x" @default.
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