FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2179969886> ?p ?o ?g. }

• W2179969886 endingPage "394" @default.
• W2179969886 startingPage "386" @default.
• W2179969886 abstract "Candida albicans is a yeast-like pathogen and can cause life-threatening systemic candidiasis. Its cell surface is enriched with mannan that is resistant to complement activation. Previously, we developed the recombinant human IgG1 antimannan antibody M1g1. M1g1 was found to promote complement activation and phagocytosis and protect mice from systemic candidiasis. Here, we evaluate the influence of IgG subclass on antimannan antibody-mediated protection. Three IgG subclass variants of M1g1 were constructed: M1g2, M1g3, and M1g4. The IgG subclass identity for each variant was confirmed with DNA sequence and subclass-specific antibodies. These variants contain identical M1 Fabs and exhibited similar binding affinities for C. albicans yeast and purified mannan. Yeast cells and hyphae recovered from the kidney of antibody-treated mice with systemic candidiasis showed uniform binding of each variant, indicating constitutive expression of the M1 epitope and antibody opsonization in the kidney. All variants promoted deposition of both murine and human C3 onto the yeast cell surface, with M1g4 showing delayed activation, as determined by flow cytometry and immunofluorescence microscopy. M1g4-mediated complement activation was found to be associated with its M1 Fab that activates the alternative pathway in an Fc-independent manner. Treatment with each subclass variant extended the survival of mice with systemic candidiasis (P < 0.001). However, treatment with M1g1, M1g3, or M1g4, but not with M1g2, also reduced the kidney fungal burden (P < 0.001). Thus, the role of human antimannan antibody in host resistance to systemic candidiasis is influenced by its IgG subclass." @default.
• W2179969886 created "2016-06-24" @default.
• W2179969886 creator A5015941993 @default.
• W2179969886 creator A5031719555 @default.
• W2179969886 creator A5033654386 @default.
• W2179969886 creator A5059703162 @default.
• W2179969886 creator A5066184996 @default.
• W2179969886 creator A5069524420 @default.
• W2179969886 date "2016-02-01" @default.
• W2179969886 modified "2023-10-17" @default.
• W2179969886 title "Influence of IgG Subclass on Human Antimannan Antibody-Mediated Resistance to Hematogenously Disseminated Candidiasis in Mice" @default.
• W2179969886 cites W1244099196 @default.
• W2179969886 cites W144288331 @default.
• W2179969886 cites W1557813967 @default.
• W2179969886 cites W1712993486 @default.
• W2179969886 cites W1901785997 @default.
• W2179969886 cites W1936531953 @default.
• W2179969886 cites W1939297816 @default.
• W2179969886 cites W1942898712 @default.
• W2179969886 cites W1944423646 @default.
• W2179969886 cites W1953315486 @default.
• W2179969886 cites W1964574920 @default.
• W2179969886 cites W1968804518 @default.
• W2179969886 cites W1973518361 @default.
• W2179969886 cites W1973722179 @default.
• W2179969886 cites W1985837387 @default.
• W2179969886 cites W1986864699 @default.
• W2179969886 cites W2012038016 @default.
• W2179969886 cites W2014653719 @default.
• W2179969886 cites W2038448241 @default.
• W2179969886 cites W2046621957 @default.
• W2179969886 cites W2057745345 @default.
• W2179969886 cites W2062983075 @default.
• W2179969886 cites W2066807229 @default.
• W2179969886 cites W2066861122 @default.
• W2179969886 cites W2104017463 @default.
• W2179969886 cites W2106519526 @default.
• W2179969886 cites W2106833014 @default.
• W2179969886 cites W2110167567 @default.
• W2179969886 cites W2110491757 @default.
• W2179969886 cites W2113744970 @default.
• W2179969886 cites W2114158362 @default.
• W2179969886 cites W2118236446 @default.
• W2179969886 cites W2129063602 @default.
• W2179969886 cites W2130346789 @default.
• W2179969886 cites W2133722333 @default.
• W2179969886 cites W2134941291 @default.
• W2179969886 cites W2135037409 @default.
• W2179969886 cites W2136790131 @default.
• W2179969886 cites W2141563676 @default.
• W2179969886 cites W2143494526 @default.
• W2179969886 cites W2149149952 @default.
• W2179969886 cites W2149373720 @default.
• W2179969886 cites W2153267886 @default.
• W2179969886 cites W2156792116 @default.
• W2179969886 cites W2158200334 @default.
• W2179969886 cites W2160956924 @default.
• W2179969886 cites W2162781391 @default.
• W2179969886 cites W2171155970 @default.
• W2179969886 cites W2301676534 @default.
• W2179969886 cites W1486232015 @default.
• W2179969886 doi "https://doi.org/10.1128/iai.00890-15" @default.
• W2179969886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4730579" @default.
• W2179969886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26573736" @default.
• W2179969886 hasPublicationYear "2016" @default.
• W2179969886 type Work @default.
• W2179969886 sameAs 2179969886 @default.
• W2179969886 citedByCount "5" @default.
• W2179969886 countsByYear W21799698862017 @default.
• W2179969886 countsByYear W21799698862020 @default.
• W2179969886 countsByYear W21799698862021 @default.
• W2179969886 countsByYear W21799698862023 @default.
• W2179969886 crossrefType "journal-article" @default.
• W2179969886 hasAuthorship W2179969886A5015941993 @default.
• W2179969886 hasAuthorship W2179969886A5031719555 @default.
• W2179969886 hasAuthorship W2179969886A5033654386 @default.
• W2179969886 hasAuthorship W2179969886A5059703162 @default.
• W2179969886 hasAuthorship W2179969886A5066184996 @default.
• W2179969886 hasAuthorship W2179969886A5069524420 @default.
• W2179969886 hasBestOaLocation W21799698861 @default.
• W2179969886 hasConcept C100817775 @default.
• W2179969886 hasConcept C111684460 @default.
• W2179969886 hasConcept C145081991 @default.
• W2179969886 hasConcept C159654299 @default.
• W2179969886 hasConcept C168507396 @default.
• W2179969886 hasConcept C203014093 @default.
• W2179969886 hasConcept C2776194381 @default.
• W2179969886 hasConcept C2779719659 @default.
• W2179969886 hasConcept C2779959462 @default.
• W2179969886 hasConcept C2780917455 @default.
• W2179969886 hasConcept C55493867 @default.
• W2179969886 hasConcept C86803240 @default.
• W2179969886 hasConcept C89372155 @default.
• W2179969886 hasConcept C89423630 @default.
• W2179969886 hasConceptScore W2179969886C100817775 @default.
• W2179969886 hasConceptScore W2179969886C111684460 @default.
• W2179969886 hasConceptScore W2179969886C145081991 @default.
• W2179969886 hasConceptScore W2179969886C159654299 @default.

• next