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• W2180038146 abstract "INTRODUCTION: Since 2010 WHO has recommended oral cholera vaccines as an additional strategy for cholera control. During a cholera episode pregnant women are at high risk of complications and the risk of fetal death has been reported to be 2-36%. Due to a lack of safety data pregnant women have been excluded from most cholera vaccination campaigns. In 2012 reactive campaigns using the bivalent killed whole-cell oral cholera vaccine (BivWC) included all people living in the targeted areas aged >/= 1 year regardless of pregnancy status were implemented in Guinea. We aimed to determine whether there was a difference in pregnancy outcomes between vaccinated and non-vaccinated pregnant women. METHODS AND FINDINGS: From 11 November to 4 December 2013 we conducted a retrospective cohort study in Boffa prefecture among women who were pregnant in 2012 during or after the vaccination campaign. The primary outcome was pregnancy loss as reported by the mother and fetal malformations after clinical examination. Primary exposure was the intake of the BivWC vaccine (Shanchol) during pregnancy as determined by a vaccination card or oral history. We compared the risk of pregnancy loss between vaccinated and non-vaccinated women through binomial regression analysis. A total of 2494 pregnancies were included in the analysis. The crude incidence of pregnancy loss was 3.7% (95%CI 2.7-4.8) for fetuses exposed to BivWC vaccine and 2.6% (0.7-4.5) for non-exposed fetuses. The incidence of malformation was 0.6% (0.1-1.0) and 1.2% (0.0-2.5) in BivWC-exposed and non-exposed fetuses respectively. In both crude and adjusted analyses fetal exposure to BivWC was not significantly associated with pregnancy loss (adjusted risk ratio (aRR = 1.09 [95%CI: 0.5-2.25] p = 0.818) or malformations (aRR = 0.50 [95%CI: 0.13-1.91] p = 0.314). CONCLUSIONS: In this large retrospective cohort study we found no association between fetal exposure to BivWC and risk of pregnancy loss or malformation. Despite the weaknesses of a retrospective design we can conclude that if a risk exists it is very low. Additional prospective studies are warranted to add to the evidence base on OCV use during pregnancy. Pregnant women are particularly vulnerable during cholera episodes and should be included in vaccination campaigns when the risk of cholera is high such as during outbreaks." @default.
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• W2180038146 date "2015-05-06" @default.
• W2180038146 modified "2023-09-27" @default.
• W2180038146 title "Pregnancy outcomes after a mass vaccination campaign with an oral cholera vaccine in Guinea: a retrospective cohort study" @default.
• W2180038146 doi "https://doi.org/10.7490/f1000research.1000078.1" @default.
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